DKKL1 — 41 ClinVar variants
All ClinVar germline DKKL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Benign · 2 Likely benign · 37 Uncertain significance
Full DKKL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DKKL1 p.Ala130Pro Uncertain significance Single submitter
- DKKL1 p.Ala130Val Uncertain significance Single submitter
- DKKL1 p.Ala168Thr Uncertain significance Single submitter
- DKKL1 p.Ala199Thr Uncertain significance Single submitter
- DKKL1 p.Arg177Gln Uncertain significance Single submitter
- DKKL1 p.Arg177Trp Uncertain significance Single submitter
- DKKL1 p.Arg196His Uncertain significance Single submitter
- DKKL1 p.Arg201Gln Uncertain significance Single submitter
- DKKL1 p.Arg205Gly Uncertain significance Single submitter
- DKKL1 p.Arg205His Uncertain significance Single submitter
- DKKL1 p.Arg57Gln Uncertain significance Single submitter
- DKKL1 p.Arg57Leu Uncertain significance Single submitter
- DKKL1 p.Arg66Leu Uncertain significance Single submitter
- DKKL1 p.Asn98Lys Uncertain significance Single submitter
- DKKL1 p.Asp69Glu Uncertain significance Single submitter
- DKKL1 p.Glu145Lys Uncertain significance Single submitter
- DKKL1 p.Glu40Lys Uncertain significance Single submitter
- DKKL1 p.Gly115Glu Uncertain significance Single submitter
- DKKL1 p.Gly216Trp Uncertain significance Single submitter
- DKKL1 p.Gly54Arg Uncertain significance Single submitter
- DKKL1 p.Leu232Val Uncertain significance Single submitter
- DKKL1 p.Lys146Asn Uncertain significance Single submitter
- DKKL1 p.Lys210Arg Uncertain significance Single submitter
- DKKL1 p.Phe134Ser Uncertain significance Single submitter
- DKKL1 p.Phe159Cys Uncertain significance Single submitter
- DKKL1 p.Pro151Ser Uncertain significance Single submitter
- DKKL1 p.Pro9Thr Uncertain significance Single submitter
- DKKL1 p.Ser223Cys Uncertain significance Single submitter
- DKKL1 p.Ser22Phe Uncertain significance Single submitter
- DKKL1 p.Ser5Phe Uncertain significance Single submitter
- DKKL1 p.Ser73Ala Uncertain significance Single submitter
- DKKL1 p.Val212Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All DKKL1 variants
Benign 2
- p.Arg166Gln Multiple submitters
- p.Met109Arg Multiple submitters
Likely benign 2
- p.Lys206Glu Single submitter
- p.Ser219Gly Single submitter
Uncertain significance 37
- p.Ala125Glu Single submitter ⚠
- p.Ala130Pro Single submitter ⚠
- p.Ala130Val Single submitter ⚠
- p.Ala168Thr Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg196His Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg205Gly Single submitter ⚠
- p.Arg205His Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg57Leu Single submitter ⚠
- p.Arg66Leu Single submitter ⚠
- p.Asn98Lys Single submitter ⚠
- p.Asp69Glu Single submitter ⚠
- p.Glu145Lys Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.Gly115Glu Single submitter ⚠
- p.Gly216Trp Single submitter ⚠
- p.Gly54Arg Single submitter ⚠
- p.Ile119Asn Single submitter ⚠
- p.Leu100His Single submitter ⚠
- p.Leu232Val Single submitter ⚠
- p.Lys146Asn Single submitter ⚠
- p.Lys210Arg Single submitter ⚠
- p.Phe134Ser Single submitter ⚠
- p.Phe159Cys Single submitter ⚠
- p.Phe169Ser Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro151Ser Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser223Cys Single submitter ⚠
- p.Ser22Phe Single submitter ⚠
- p.Ser5Phe Single submitter ⚠
- p.Ser73Ala Single submitter ⚠
- p.Val212Ile Single submitter ⚠