Sugi Variant

Sugi Variant/DLC1

DLC1 — 812 ClinVar variants

All ClinVar germline DLC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 525 flagged for review →

1 Pathogenic · 17 Conflicting · 95 Benign · 2 Benign/Likely benign · 141 Likely benign · 556 Uncertain significance

Full DLC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 525

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 9

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 317

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 317

Predictors split 198

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 198

All DLC1 variants

Pathogenic 1

Conflicting classifications of pathogenicity 17

Benign 95

Benign/Likely benign 2

Likely benign 141

Uncertain significance 556

Showing the top 300 by review status; the full set is in the sitemap.