DLEU7 — 35 ClinVar variants
All ClinVar germline DLEU7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Likely benign · 34 Uncertain significance
Full DLEU7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLEU7 p.Ala49Thr Uncertain significance Single submitter
- DLEU7 p.Ala51Thr Uncertain significance Single submitter
- DLEU7 p.Ala83Pro Uncertain significance Single submitter
- DLEU7 p.Ala9Ser Uncertain significance Single submitter
- DLEU7 p.Arg52Ser Uncertain significance Single submitter
- DLEU7 p.Arg77Pro Uncertain significance Single submitter
- DLEU7 p.Asp32Asn Uncertain significance Single submitter
- DLEU7 p.Glu66Gln Uncertain significance Single submitter
- DLEU7 p.Glu67Gly Uncertain significance Single submitter
- DLEU7 p.Glu89Ala Uncertain significance Single submitter
- DLEU7 p.Gly140Glu Uncertain significance Single submitter
- DLEU7 p.Gly38Glu Uncertain significance Single submitter
- DLEU7 p.Gly73Ala Uncertain significance Single submitter
- DLEU7 p.Phe103Leu Uncertain significance Single submitter
- DLEU7 p.Pro104Leu Uncertain significance Single submitter
- DLEU7 p.Pro109Thr Uncertain significance Single submitter
- DLEU7 p.Pro43Thr Uncertain significance Single submitter
- DLEU7 p.Pro56Leu Uncertain significance Single submitter
- DLEU7 p.Pro63Thr Uncertain significance Single submitter
- DLEU7 p.Ser76Arg Uncertain significance Single submitter
- DLEU7 p.Trp30Leu Uncertain significance Single submitter
- DLEU7 p.Val72Met Uncertain significance Single submitter
- DLEU7 p.Val90Glu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DLEU7 p.Ala2Val Uncertain significance Single submitter
- DLEU7 p.Ala80Thr Uncertain significance Single submitter
- DLEU7 p.Arg123Gly Uncertain significance Single submitter
- DLEU7 p.Arg41Trp Uncertain significance Single submitter
- DLEU7 p.Arg58Gln Uncertain significance Single submitter
- DLEU7 p.Pro149Arg Uncertain significance Single submitter
- DLEU7 p.Pro61Gln Uncertain significance Single submitter
- DLEU7 p.Ser129Leu Uncertain significance Single submitter
- DLEU7 p.Val46Met Uncertain significance Single submitter
All DLEU7 variants
Likely benign 1
- p.Arg77Gly Single submitter
Uncertain significance 34
- p.Ala2Val Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Ala80Thr Single submitter ⚠
- p.Ala83Pro Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg52Ser Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg77Pro Single submitter ⚠
- p.Asn159Tyr Single submitter
- p.Asp32Asn Single submitter ⚠
- p.Glu66Gln Single submitter ⚠
- p.Glu67Gly Single submitter ⚠
- p.Glu89Ala Single submitter ⚠
- p.Gly140Glu Single submitter ⚠
- p.Gly38Glu Single submitter ⚠
- p.Gly73Ala Single submitter ⚠
- p.Leu157Pro Single submitter
- p.Phe103Leu Single submitter ⚠
- p.Pro104Leu Single submitter ⚠
- p.Pro109Thr Single submitter ⚠
- p.Pro149Arg Single submitter ⚠
- p.Pro43Thr Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Pro61Gln Single submitter ⚠
- p.Pro63Thr Single submitter ⚠
- p.Ser129Leu Single submitter ⚠
- p.Ser76Arg Single submitter ⚠
- p.Trp30Leu Single submitter ⚠
- p.Val46Met Single submitter ⚠
- p.Val72Met Single submitter ⚠
- p.Val90Glu Single submitter ⚠