DLG2 — 92 ClinVar variants
All ClinVar germline DLG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
5 Benign · 1 Benign/Likely benign · 8 Likely benign · 78 Uncertain significance
Full DLG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLG2 p.Ala128Pro Uncertain significance Single submitter
- DLG2 p.Ala366Thr Uncertain significance Single submitter
- DLG2 p.Ala482Pro Uncertain significance Single submitter
- DLG2 p.Ala583Val Uncertain significance Single submitter
- DLG2 p.Ala595Asp Uncertain significance Single submitter
- DLG2 p.Arg142Gly Uncertain significance Single submitter
- DLG2 p.Arg612Gly Uncertain significance Single submitter
- DLG2 p.Arg642Cys Uncertain significance Single submitter
- DLG2 p.Arg642His Uncertain significance Single submitter
- DLG2 p.Arg688Ser Uncertain significance Single submitter
- DLG2 p.Arg786Gln Uncertain significance Single submitter
- DLG2 p.Arg797Gly Uncertain significance Single submitter
- DLG2 p.Arg873Lys Uncertain significance Single submitter
- DLG2 p.Asn414Ser Uncertain significance Single submitter
- DLG2 p.Asp442Gly Uncertain significance Single submitter
- DLG2 p.Asp443Tyr Uncertain significance Single submitter
- DLG2 p.Asp494Asn Uncertain significance Single submitter
-
DLG2 p.Asp657Tyr
Uncertain significance
Single submitter
DLG2-related disorder
- DLG2 p.Asp681His Uncertain significance Single submitter
- DLG2 p.Gln502Lys Uncertain significance Single submitter
- DLG2 p.Glu140Lys Uncertain significance Single submitter
- DLG2 p.Gly546Glu Uncertain significance Single submitter
- DLG2 p.His132Tyr Uncertain significance Single submitter
- DLG2 p.His503Arg Uncertain significance Single submitter
- DLG2 p.Ile427Val Uncertain significance Single submitter
- DLG2 p.Ile897Phe Uncertain significance Single submitter
- DLG2 p.Ile951Thr Uncertain significance Single submitter
- DLG2 p.Leu344Met Uncertain significance Single submitter
- DLG2 p.Leu479Phe Uncertain significance Single submitter
- DLG2 p.Lys462Arg Uncertain significance Single submitter
- DLG2 p.Met439Lys Uncertain significance Single submitter
- DLG2 p.Met629Val Uncertain significance Single submitter
- DLG2 p.Pro434Ala Uncertain significance Single submitter
- DLG2 p.Pro471Ser Uncertain significance Single submitter
- DLG2 p.Pro763Leu Uncertain significance Single submitter
- DLG2 p.Ser170Pro Uncertain significance Single submitter
- DLG2 p.Ser267Phe Uncertain significance Single submitter
- DLG2 p.Ser477Asn Uncertain significance Single submitter
-
DLG2 p.Thr373Pro
Uncertain significance
Single submitter
DLG2-related disorder
- DLG2 p.Thr505Ala Uncertain significance Single submitter
- DLG2 p.Val296Ile Uncertain significance Single submitter
- DLG2 p.Val329Ala Uncertain significance Single submitter
- DLG2 p.Val726Ala Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- DLG2 p.Arg257Gln Uncertain significance Single submitter
- DLG2 p.Arg516Trp Uncertain significance Single submitter
- DLG2 p.Asn210Ser Uncertain significance Single submitter
- DLG2 p.Asn626His Uncertain significance Single submitter
- DLG2 p.Asn752Asp Uncertain significance Single submitter
- DLG2 p.Asp334Gly Uncertain significance Single submitter
- DLG2 p.Cys955Ser Uncertain significance Single submitter
- DLG2 p.Glu158Gly Uncertain significance Single submitter
- DLG2 p.Glu565Lys Uncertain significance Single submitter
- DLG2 p.Glu696Gln Uncertain significance Single submitter
- DLG2 p.Glu759Gly Uncertain significance Single submitter
- DLG2 p.Glu872Gly Uncertain significance Single submitter
- DLG2 p.Gly594Ala Uncertain significance Single submitter
- DLG2 p.Gly594Arg Uncertain significance Single submitter
- DLG2 p.Gly634Ala Uncertain significance Single submitter
- DLG2 p.Ile281Thr Uncertain significance Single submitter
- DLG2 p.Ile951Met Uncertain significance Single submitter
- DLG2 p.Leu351Val Uncertain significance Single submitter
- DLG2 p.Leu555Met Uncertain significance Single submitter
- DLG2 p.Lys739Glu Uncertain significance Single submitter
- DLG2 p.Phe741Val Uncertain significance Single submitter
- DLG2 p.Pro176Leu Uncertain significance Single submitter
- DLG2 p.Pro436Leu Uncertain significance Single submitter
- DLG2 p.Pro449Ser Uncertain significance Single submitter
- DLG2 p.Ser269Asn Uncertain significance Single submitter
-
DLG2 p.Ser412Cys
Uncertain significance
Single submitter
DLG2-related disorder
- DLG2 p.Ser519Phe Uncertain significance Single submitter
-
DLG2 p.Thr386Ile
Uncertain significance
Single submitter
DLG2-related disorder
- DLG2 p.Thr785Ile Uncertain significance Single submitter
- DLG2 p.Tyr393Cys Uncertain significance Single submitter
- DLG2 p.Val958Ala Uncertain significance Single submitter
All DLG2 variants
Benign 5
Benign/Likely benign 1
- p.Ser804= Multiple submitters
Likely benign 8
- p.Leu514Pro Multiple submitters
- p.Gly219= Single submitter
- p.Gly220= Single submitter
- p.Met512Val Single submitter
- p.Ser499= Single submitter
- p.Thr47= Single submitter
- p.Val141= Single submitter
- p.Ala506Thr No assertion criteria DLG2-related disorder
Uncertain significance 78
- c.1825_1825+3del Single submitter DLG2-related disorder
- c.2194-3_2194-2del Single submitter DLG2-related disorder
- c.624+1G>A Single submitter
- p.Ala128Pro Single submitter ⚠
- p.Ala366Thr Single submitter ⚠
- p.Ala482Pro Single submitter ⚠
- p.Ala583Val Single submitter ⚠
- p.Ala595Asp Single submitter ⚠
- p.Arg142Gly Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg516Trp Single submitter ⚠
- p.Arg612Gly Single submitter ⚠
- p.Arg642Cys Single submitter ⚠
- p.Arg642His Single submitter ⚠
- p.Arg688Ser Single submitter ⚠
- p.Arg786Gln Single submitter ⚠
- p.Arg797Gly Single submitter ⚠
- p.Arg873Lys Single submitter ⚠
- p.Asn210Ser Single submitter ⚠
- p.Asn414Ser Single submitter ⚠
- p.Asn626His Single submitter ⚠
- p.Asn752Asp Single submitter ⚠
- p.Asp334Gly Single submitter ⚠
- p.Asp442Gly Single submitter ⚠
- p.Asp443Tyr Single submitter ⚠
- p.Asp494Asn Single submitter ⚠
- p.Asp657Tyr Single submitter DLG2-related disorder ⚠
- p.Asp681His Single submitter ⚠
- p.Cys955Ser Single submitter ⚠
- p.Gln502Lys Single submitter ⚠
- p.Glu140Lys Single submitter ⚠
- p.Glu158Gly Single submitter ⚠
- p.Glu565Lys Single submitter ⚠
- p.Glu696Gln Single submitter ⚠
- p.Glu759Gly Single submitter ⚠
- p.Glu872Gly Single submitter ⚠
- p.Gly546Glu Single submitter ⚠
- p.Gly594Ala Single submitter ⚠
- p.Gly594Arg Single submitter ⚠
- p.Gly634Ala Single submitter ⚠
- p.His132Tyr Single submitter ⚠
- p.His503Arg Single submitter ⚠
- p.Ile281Thr Single submitter ⚠
- p.Ile427Val Single submitter ⚠
- p.Ile897Phe Single submitter ⚠
- p.Ile951Met Single submitter ⚠
- p.Ile951Thr Single submitter ⚠
- p.Leu344Met Single submitter ⚠
- p.Leu351Val Single submitter ⚠
- p.Leu479Phe Single submitter ⚠
- p.Leu555Met Single submitter ⚠
- p.Lys462Arg Single submitter ⚠
- p.Lys739Glu Single submitter ⚠
- p.Met439Lys Single submitter ⚠
- p.Met629Val Single submitter ⚠
- p.Phe741Val Single submitter ⚠
- p.Pro176Leu Single submitter ⚠
- p.Pro434Ala Single submitter ⚠
- p.Pro436Leu Single submitter ⚠
- p.Pro449Ser Single submitter ⚠
- p.Pro471Ser Single submitter ⚠
- p.Pro763Leu Single submitter ⚠
- p.Ser170Pro Single submitter ⚠
- p.Ser267Phe Single submitter ⚠
- p.Ser269Asn Single submitter ⚠
- p.Ser412Cys Single submitter DLG2-related disorder ⚠
- p.Ser477Asn Single submitter ⚠
- p.Ser519Phe Single submitter ⚠
- p.Thr373Pro Single submitter DLG2-related disorder ⚠
- p.Thr386Ile Single submitter DLG2-related disorder ⚠
- p.Thr505Ala Single submitter ⚠
- p.Thr785Ile Single submitter ⚠
- p.Trp112Ter Single submitter
- p.Tyr393Cys Single submitter ⚠
- p.Val296Ile Single submitter ⚠
- p.Val329Ala Single submitter ⚠
- p.Val726Ala Single submitter ⚠
- p.Val958Ala Single submitter ⚠