DLGAP4 — 129 ClinVar variants
All ClinVar germline DLGAP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
3 Benign · 10 Likely benign · 116 Uncertain significance
Full DLGAP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLGAP4 p.Ala131Thr Uncertain significance Single submitter
- DLGAP4 p.Ala154Pro Uncertain significance Single submitter
- DLGAP4 p.Ala154Ser Uncertain significance Single submitter
- DLGAP4 p.Ala161Val Uncertain significance Single submitter
- DLGAP4 p.Ala190Thr Uncertain significance Single submitter
- DLGAP4 p.Ala266Thr Uncertain significance Single submitter
- DLGAP4 p.Ala39Val Uncertain significance Single submitter
- DLGAP4 p.Ala481Val Uncertain significance Single submitter
- DLGAP4 p.Ala641Pro Uncertain significance Single submitter
- DLGAP4 p.Ala939Val Uncertain significance Single submitter
- DLGAP4 p.Ala945Thr Uncertain significance Single submitter
- DLGAP4 p.Arg219Gly Uncertain significance Single submitter
- DLGAP4 p.Arg29Cys Uncertain significance Single submitter
- DLGAP4 p.Arg29His Uncertain significance Single submitter
- DLGAP4 p.Arg418Leu Uncertain significance Single submitter
- DLGAP4 p.Arg45Cys Uncertain significance Single submitter
- DLGAP4 p.Arg471Gln Uncertain significance Single submitter
- DLGAP4 p.Arg515Cys Uncertain significance Single submitter
- DLGAP4 p.Arg515His Uncertain significance Single submitter
- DLGAP4 p.Arg760His Uncertain significance Single submitter
- DLGAP4 p.Arg801Cys Uncertain significance Single submitter
- DLGAP4 p.Asn30Ser Uncertain significance Single submitter
- DLGAP4 p.Asn761Ser Uncertain significance Single submitter
- DLGAP4 p.Asp212Glu Uncertain significance Single submitter
- DLGAP4 p.Asp352Asn Uncertain significance Single submitter
- DLGAP4 p.Asp720Asn Uncertain significance Single submitter
- DLGAP4 p.Cys726Tyr Uncertain significance Single submitter
- DLGAP4 p.Cys736Tyr Uncertain significance Single submitter
- DLGAP4 p.Gln63Lys Uncertain significance Single submitter
- DLGAP4 p.Glu128Lys Uncertain significance Single submitter
- DLGAP4 p.Glu214Lys Uncertain significance Single submitter
- DLGAP4 p.Glu263Gln Uncertain significance Single submitter
- DLGAP4 p.Glu350Gln Uncertain significance Single submitter
- DLGAP4 p.Glu376Gln Uncertain significance Single submitter
- DLGAP4 p.Glu43Lys Uncertain significance Single submitter
- DLGAP4 p.Gly177Ser Uncertain significance Single submitter
- DLGAP4 p.Gly213Asp Uncertain significance Single submitter
- DLGAP4 p.Gly216Ser Uncertain significance Single submitter
- DLGAP4 p.Gly326Val Uncertain significance Single submitter
- DLGAP4 p.Gly56Asp Uncertain significance Single submitter
- DLGAP4 p.Gly56Ser Uncertain significance Single submitter
- DLGAP4 p.Gly748Ser Uncertain significance Single submitter
- DLGAP4 p.His303Gln Uncertain significance Single submitter
- DLGAP4 p.His466Gln Uncertain significance Single submitter
- DLGAP4 p.His639Asp Uncertain significance Single submitter
- DLGAP4 p.Leu23Pro Uncertain significance Single submitter
- DLGAP4 p.Lys189Glu Uncertain significance Single submitter
- DLGAP4 p.Lys315Thr Uncertain significance Single submitter
- DLGAP4 p.Lys754Arg Uncertain significance Single submitter
- DLGAP4 p.Met708Thr Uncertain significance Single submitter
- DLGAP4 p.Pro360Leu Uncertain significance Single submitter
- DLGAP4 p.Pro431Ala Uncertain significance Single submitter
- DLGAP4 p.Pro461Ala Uncertain significance Single submitter
- DLGAP4 p.Pro53Arg Uncertain significance Single submitter
- DLGAP4 p.Pro618Leu Uncertain significance Single submitter
- DLGAP4 p.Pro656Ala Uncertain significance Single submitter
- DLGAP4 p.Pro67Ala Uncertain significance Single submitter
- DLGAP4 p.Pro734Leu Uncertain significance Single submitter
- DLGAP4 p.Pro749Thr Uncertain significance Single submitter
- DLGAP4 p.Pro791Ser Uncertain significance Single submitter
- DLGAP4 p.Ser342Asn Uncertain significance Single submitter
- DLGAP4 p.Ser384Gly Uncertain significance Single submitter
- DLGAP4 p.Ser441Gly Uncertain significance Single submitter
- DLGAP4 p.Ser508Phe Uncertain significance Single submitter
- DLGAP4 p.Ser724Leu Uncertain significance Single submitter
- DLGAP4 p.Ser776Leu Uncertain significance Single submitter
- DLGAP4 p.Thr276Ala Uncertain significance Single submitter
- DLGAP4 p.Thr344Pro Uncertain significance Single submitter
- DLGAP4 p.Thr497Met Uncertain significance Single submitter
- DLGAP4 p.Val289Ile Uncertain significance Single submitter
- DLGAP4 p.Val703Ile Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- DLGAP4 p.Arg10Cys Uncertain significance Single submitter
- DLGAP4 p.Arg116Cys Uncertain significance Single submitter
- DLGAP4 p.Arg126His Uncertain significance Single submitter
- DLGAP4 p.Arg148Trp Uncertain significance Single submitter
- DLGAP4 p.Arg195Trp Uncertain significance Single submitter
- DLGAP4 p.Arg232Cys Uncertain significance Single submitter
- DLGAP4 p.Arg232His Uncertain significance Single submitter
- DLGAP4 p.Arg236Cys Uncertain significance Single submitter
- DLGAP4 p.Arg236His Uncertain significance Single submitter
- DLGAP4 p.Arg291Gln Uncertain significance Single submitter
- DLGAP4 p.Arg418Cys Uncertain significance Single submitter
- DLGAP4 p.Arg712Trp Uncertain significance Single submitter
- DLGAP4 p.Arg73His Uncertain significance Single submitter
- DLGAP4 p.Arg750Trp Uncertain significance Single submitter
- DLGAP4 p.Arg802Gln Uncertain significance Single submitter
- DLGAP4 p.Arg942Cys Uncertain significance Single submitter
- DLGAP4 p.Asn98Asp Uncertain significance Single submitter
- DLGAP4 p.Asp212Asn Uncertain significance Single submitter
- DLGAP4 p.Glu484Lys Uncertain significance Single submitter
- DLGAP4 p.Glu917Gln Uncertain significance Single submitter
- DLGAP4 p.Gly216Cys Uncertain significance Single submitter
- DLGAP4 p.Gly367Val Uncertain significance Single submitter
- DLGAP4 p.Ile74Ser Uncertain significance Single submitter
- DLGAP4 p.Leu416Met Uncertain significance Single submitter
- DLGAP4 p.Met373Val Uncertain significance Single submitter
- DLGAP4 p.Pro269Ser Uncertain significance Single submitter
- DLGAP4 p.Pro270Leu Uncertain significance Single submitter
- DLGAP4 p.Pro389Ser Uncertain significance Single submitter
- DLGAP4 p.Pro572Leu Uncertain significance Single submitter
- DLGAP4 p.Pro778Leu Uncertain significance Single submitter
- DLGAP4 p.Pro782Ser Uncertain significance Single submitter
- DLGAP4 p.Pro927Thr Uncertain significance Single submitter
- DLGAP4 p.Pro928Leu Uncertain significance Single submitter
- DLGAP4 p.Ser428Cys Uncertain significance Single submitter
- DLGAP4 p.Ser451Asn Uncertain significance Single submitter
- DLGAP4 p.Ser527Asn Uncertain significance Single submitter
- DLGAP4 p.Ser606Gly Uncertain significance Single submitter
- DLGAP4 p.Ser614Arg Uncertain significance Single submitter
- DLGAP4 p.Ser615Asn Uncertain significance Single submitter
- DLGAP4 p.Ser654Phe Uncertain significance Single submitter
- DLGAP4 p.Thr547Met Uncertain significance Single submitter
- DLGAP4 p.Val282Met Uncertain significance Single submitter
- DLGAP4 p.Val334Ala Uncertain significance Single submitter
- DLGAP4 p.Val929Phe Uncertain significance Single submitter
All DLGAP4 variants
Benign 3
- p.Ala845= Multiple submitters
- p.Ala245Thr Single submitter
- p.Gly165Ser Single submitter
Likely benign 10
- p.Gly540Ser Multiple submitters
- p.Pro270= Multiple submitters
- p.Ala627Thr Single submitter
- p.Arg662= Single submitter
- p.Asn607= Single submitter
- p.Met174Leu Single submitter
- p.Pro926= Single submitter
- p.Pro938= Single submitter
- p.Ser787Thr Single submitter
- p.Val440Ile Single submitter
Uncertain significance 116
- c.2011-343A>T Single submitter
- p.Ala131Thr Single submitter ⚠
- p.Ala154Pro Single submitter ⚠
- p.Ala154Ser Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala190Thr Single submitter ⚠
- p.Ala266Thr Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala481Val Single submitter ⚠
- p.Ala641Pro Single submitter ⚠
- p.Ala939Val Single submitter ⚠
- p.Ala945Thr Single submitter ⚠
- p.Arg10Cys Single submitter ⚠
- p.Arg116Cys Single submitter ⚠
- p.Arg126His Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg195Trp Single submitter ⚠
- p.Arg219Gly Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg232His Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg236His Single submitter ⚠
- p.Arg291Gln Single submitter ⚠
- p.Arg29Cys Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg418Leu Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Arg471Gln Single submitter ⚠
- p.Arg515Cys Single submitter ⚠
- p.Arg515His Single submitter ⚠
- p.Arg712Trp Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Arg750Trp Single submitter ⚠
- p.Arg760His Single submitter ⚠
- p.Arg801Cys Single submitter ⚠
- p.Arg802Gln Single submitter ⚠
- p.Arg942Cys Single submitter ⚠
- p.Asn30Ser Single submitter ⚠
- p.Asn761Ser Single submitter ⚠
- p.Asn98Asp Single submitter ⚠
- p.Asp212Asn Single submitter ⚠
- p.Asp212Glu Single submitter ⚠
- p.Asp352Asn Single submitter ⚠
- p.Asp720Asn Single submitter ⚠
- p.Cys726Tyr Single submitter ⚠
- p.Cys736Tyr Single submitter ⚠
- p.Gln63Lys Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Glu214Lys Single submitter ⚠
- p.Glu263Gln Single submitter ⚠
- p.Glu350Gln Single submitter ⚠
- p.Glu376Gln Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu484Lys Single submitter ⚠
- p.Glu917Gln Single submitter ⚠
- p.Gly177Ser Single submitter ⚠
- p.Gly213Asp Single submitter ⚠
- p.Gly216Cys Single submitter ⚠
- p.Gly216Ser Single submitter ⚠
- p.Gly326Val Single submitter ⚠
- p.Gly367Val Single submitter ⚠
- p.Gly56Asp Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.Gly748Ser Single submitter ⚠
- p.His303Gln Single submitter ⚠
- p.His466Gln Single submitter ⚠
- p.His639Asp Single submitter ⚠
- p.Ile74Ser Single submitter ⚠
- p.Leu23Pro Single submitter ⚠
- p.Leu416Met Single submitter ⚠
- p.Lys189Glu Single submitter ⚠
- p.Lys315Thr Single submitter ⚠
- p.Lys754Arg Single submitter ⚠
- p.Met373Val Single submitter ⚠
- p.Met708Thr Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro270Leu Single submitter ⚠
- p.Pro360Leu Single submitter ⚠
- p.Pro389Ser Single submitter ⚠
- p.Pro431Ala Single submitter ⚠
- p.Pro461Ala Single submitter ⚠
- p.Pro53Arg Single submitter ⚠
- p.Pro572Leu Single submitter ⚠
- p.Pro618Leu Single submitter ⚠
- p.Pro656Ala Single submitter ⚠
- p.Pro67Ala Single submitter ⚠
- p.Pro734Leu Single submitter ⚠
- p.Pro749Thr Single submitter ⚠
- p.Pro778Leu Single submitter ⚠
- p.Pro782Ser Single submitter ⚠
- p.Pro791Ser Single submitter ⚠
- p.Pro927Thr Single submitter ⚠
- p.Pro928Leu Single submitter ⚠
- p.Ser342Asn Single submitter ⚠
- p.Ser384Gly Single submitter ⚠
- p.Ser428Cys Single submitter ⚠
- p.Ser441Gly Single submitter ⚠
- p.Ser451Asn Single submitter ⚠
- p.Ser508Phe Single submitter ⚠
- p.Ser527Asn Single submitter ⚠
- p.Ser606Gly Single submitter ⚠
- p.Ser614Arg Single submitter ⚠
- p.Ser615Asn Single submitter ⚠
- p.Ser654Phe Single submitter ⚠
- p.Ser724Leu Single submitter ⚠
- p.Ser776Leu Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Thr344Pro Single submitter ⚠
- p.Thr497Met Single submitter ⚠
- p.Thr547Met Single submitter ⚠
- p.Val282Met Single submitter ⚠
- p.Val289Ile Single submitter ⚠
- p.Val334Ala Single submitter ⚠
- p.Val703Ile Single submitter ⚠
- p.Val929Phe Single submitter ⚠