DLX1 — 24 ClinVar variants
All ClinVar germline DLX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
1 Likely benign · 23 Uncertain significance
Full DLX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLX1 p.Ala106Pro Uncertain significance Single submitter
- DLX1 p.Ala192Val Uncertain significance Single submitter
- DLX1 p.Ala198Thr Uncertain significance Single submitter
- DLX1 p.Ala200Thr Uncertain significance Single submitter
- DLX1 p.Ala200Val Uncertain significance Single submitter
- DLX1 p.Arg180Gln Uncertain significance Single submitter
- DLX1 p.Gly228Val Uncertain significance Single submitter
- DLX1 p.Met255Lys Uncertain significance Single submitter
- DLX1 p.Met35Val Uncertain significance Single submitter
- DLX1 p.Pro218Thr Uncertain significance Single submitter
- DLX1 p.Pro235Ser Uncertain significance Single submitter
- DLX1 p.Ser111Arg Uncertain significance Single submitter
- DLX1 p.Ser181Phe Uncertain significance Single submitter
- DLX1 p.Ser236Arg Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DLX1 p.Ala204Val Uncertain significance Single submitter
- DLX1 p.Arg100Cys Uncertain significance Single submitter
- DLX1 p.Arg100Leu Uncertain significance Single submitter
- DLX1 p.His37Gln Uncertain significance Single submitter
- DLX1 p.Ser222Thr Uncertain significance Single submitter
- DLX1 p.Ser239Thr Uncertain significance Single submitter
- DLX1 p.Ser76Asn Uncertain significance Single submitter
- DLX1 p.Ser95Ile Uncertain significance Single submitter
- DLX1 p.Ser95Thr Uncertain significance Single submitter
All DLX1 variants
Likely benign 1
- p.Leu194= Single submitter
Uncertain significance 23
- p.Ala106Pro Single submitter ⚠
- p.Ala192Val Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala200Thr Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala204Val Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg100Leu Single submitter ⚠
- p.Arg180Gln Single submitter ⚠
- p.Gly228Val Single submitter ⚠
- p.His37Gln Single submitter ⚠
- p.Met255Lys Single submitter ⚠
- p.Met35Val Single submitter ⚠
- p.Pro218Thr Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Ser111Arg Single submitter ⚠
- p.Ser181Phe Single submitter ⚠
- p.Ser222Thr Single submitter ⚠
- p.Ser236Arg Single submitter ⚠
- p.Ser239Thr Single submitter ⚠
- p.Ser76Asn Single submitter ⚠
- p.Ser95Ile Single submitter ⚠
- p.Ser95Thr Single submitter ⚠