DLX2 — 47 ClinVar variants
All ClinVar germline DLX2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 1 Likely benign · 44 Uncertain significance
Full DLX2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DLX2 p.Ala19Ser Uncertain significance Single submitter
- DLX2 p.Ala239Thr Uncertain significance Single submitter
- DLX2 p.Ala61Thr Uncertain significance Single submitter
- DLX2 p.Gln247Pro Uncertain significance Single submitter
- DLX2 p.Gln93Arg Uncertain significance Single submitter
- DLX2 p.Gly147Arg Uncertain significance Single submitter
- DLX2 p.Gly190Ser Uncertain significance Single submitter
- DLX2 p.Gly214Ser Uncertain significance Single submitter
- DLX2 p.Gly88Ser Uncertain significance Single submitter
- DLX2 p.Ile144Val Uncertain significance Single submitter
- DLX2 p.Pro149Leu Uncertain significance Single submitter
- DLX2 p.Pro234Ala Uncertain significance Single submitter
- DLX2 p.Pro246Gln Uncertain significance Single submitter
- DLX2 p.Pro269Ser Uncertain significance Single submitter
- DLX2 p.Pro298Thr Uncertain significance Single submitter
- DLX2 p.Pro306Gln Uncertain significance Single submitter
- DLX2 p.Pro30Ser Uncertain significance Single submitter
- DLX2 p.Ser265Ala Uncertain significance Single submitter
- DLX2 p.Val152Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- DLX2 p.Ala74Val Uncertain significance Single submitter
- DLX2 p.Asn99Lys Uncertain significance Single submitter
- DLX2 p.Asp63Asn Uncertain significance Single submitter
- DLX2 p.Gln285Glu Uncertain significance Single submitter
- DLX2 p.Gln294Lys Uncertain significance Single submitter
- DLX2 p.Gln91Leu Uncertain significance Single submitter
- DLX2 p.Glu136Gly Uncertain significance Single submitter
- DLX2 p.Gly263Arg Uncertain significance Single submitter
- DLX2 p.Gly263Cys Uncertain significance Single submitter
- DLX2 p.Gly288Arg Uncertain significance Single submitter
- DLX2 p.Gly319Arg Uncertain significance Single submitter
- DLX2 p.Gly34Cys Uncertain significance Single submitter
- DLX2 p.Gly78Ser Uncertain significance Single submitter
- DLX2 p.Gly88Cys Uncertain significance Single submitter
- DLX2 p.His315Arg Uncertain significance Single submitter
- DLX2 p.Pro217Leu Uncertain significance Single submitter
- DLX2 p.Pro246Arg Uncertain significance Single submitter
- DLX2 p.Pro255Arg Uncertain significance Single submitter
- DLX2 p.Ser240Cys Uncertain significance Single submitter
- DLX2 p.Ser257Arg Uncertain significance Single submitter
- DLX2 p.Ser265Leu Uncertain significance Single submitter
- DLX2 p.Ser274Leu Uncertain significance Single submitter
- DLX2 p.Ser291Leu Uncertain significance Single submitter
- DLX2 p.Tyr283Phe Uncertain significance Single submitter
- DLX2 p.Val4Asp Uncertain significance Single submitter
All DLX2 variants
Likely benign 1
- p.Ala297= Single submitter
Uncertain significance 44
- p.Ala19Ser Single submitter ⚠
- p.Ala239Thr Single submitter ⚠
- p.Ala61Thr Single submitter ⚠
- p.Ala74Val Single submitter ⚠
- p.Asn99Lys Single submitter ⚠
- p.Asp63Asn Single submitter ⚠
- p.Gln247Pro Single submitter ⚠
- p.Gln285Glu Single submitter ⚠
- p.Gln294Lys Single submitter ⚠
- p.Gln91Leu Single submitter ⚠
- p.Gln93Arg Single submitter ⚠
- p.Glu136Gly Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Gly190Ser Single submitter ⚠
- p.Gly214Ser Single submitter ⚠
- p.Gly263Arg Single submitter ⚠
- p.Gly263Cys Single submitter ⚠
- p.Gly288Arg Single submitter ⚠
- p.Gly319Arg Single submitter ⚠
- p.Gly34Cys Single submitter ⚠
- p.Gly78Ser Single submitter ⚠
- p.Gly88Cys Single submitter ⚠
- p.Gly88Ser Single submitter ⚠
- p.His315Arg Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro217Leu Single submitter ⚠
- p.Pro234Ala Single submitter ⚠
- p.Pro246Arg Single submitter ⚠
- p.Pro246Gln Single submitter ⚠
- p.Pro255Arg Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro298Thr Single submitter ⚠
- p.Pro306Gln Single submitter ⚠
- p.Pro30Ser Single submitter ⚠
- p.Ser240Cys Single submitter ⚠
- p.Ser257Arg Single submitter ⚠
- p.Ser265Ala Single submitter ⚠
- p.Ser265Leu Single submitter ⚠
- p.Ser274Leu Single submitter ⚠
- p.Ser291Leu Single submitter ⚠
- p.Tyr283Phe Single submitter ⚠
- p.Val152Ile Single submitter ⚠
- p.Val4Asp Single submitter ⚠