DMRTC2 — 52 ClinVar variants
All ClinVar germline DMRTC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
5 Likely benign · 47 Uncertain significance
Full DMRTC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DMRTC2 p.Ala202Thr Uncertain significance Single submitter
- DMRTC2 p.Ala280Val Uncertain significance Single submitter
- DMRTC2 p.Ala295Thr Uncertain significance Single submitter
- DMRTC2 p.Ala307Ser Uncertain significance Single submitter
- DMRTC2 p.Ala350Val Uncertain significance Single submitter
- DMRTC2 p.Ala35Val Uncertain significance Single submitter
- DMRTC2 p.Ala65Ser Uncertain significance Single submitter
- DMRTC2 p.Ala93Val Uncertain significance Single submitter
- DMRTC2 p.Arg195Cys Uncertain significance Single submitter
- DMRTC2 p.Arg251Cys Uncertain significance Single submitter
- DMRTC2 p.Arg281Gln Uncertain significance Single submitter
- DMRTC2 p.Arg346Gln Uncertain significance Single submitter
- DMRTC2 p.Arg359Cys Uncertain significance Single submitter
- DMRTC2 p.Arg46His Uncertain significance Single submitter
- DMRTC2 p.Arg88Cys Uncertain significance Single submitter
- DMRTC2 p.Asp24Glu Uncertain significance Single submitter
- DMRTC2 p.Asp303Val Uncertain significance Single submitter
- DMRTC2 p.Cys152Tyr Uncertain significance Single submitter
- DMRTC2 p.Cys344Arg Uncertain significance Single submitter
- DMRTC2 p.Gln94His Uncertain significance Single submitter
- DMRTC2 p.Glu67Lys Uncertain significance Single submitter
- DMRTC2 p.Gly148Arg Uncertain significance Single submitter
- DMRTC2 p.His11Arg Uncertain significance Single submitter
- DMRTC2 p.His180Gln Uncertain significance Single submitter
- DMRTC2 p.His356Arg Uncertain significance Single submitter
- DMRTC2 p.Leu324Phe Uncertain significance Single submitter
- DMRTC2 p.Lys115Arg Uncertain significance Single submitter
- DMRTC2 p.Met188Val Uncertain significance Single submitter
- DMRTC2 p.Phe208Val Uncertain significance Single submitter
- DMRTC2 p.Pro160Ser Uncertain significance Single submitter
- DMRTC2 p.Pro183Leu Uncertain significance Single submitter
- DMRTC2 p.Pro18Leu Uncertain significance Single submitter
- DMRTC2 p.Pro18Ser Uncertain significance Single submitter
- DMRTC2 p.Pro206Ser Uncertain significance Single submitter
- DMRTC2 p.Pro264Ser Uncertain significance Single submitter
- DMRTC2 p.Pro266Leu Uncertain significance Single submitter
- DMRTC2 p.Pro316Arg Uncertain significance Single submitter
- DMRTC2 p.Pro329Leu Uncertain significance Single submitter
- DMRTC2 p.Pro32Arg Uncertain significance Single submitter
- DMRTC2 p.Ser313Tyr Uncertain significance Single submitter
- DMRTC2 p.Ser362Cys Uncertain significance Single submitter
- DMRTC2 p.Val203Ile Uncertain significance Single submitter
- DMRTC2 p.Val234Ala Uncertain significance Single submitter
- DMRTC2 p.Val299Met Uncertain significance Single submitter
- DMRTC2 p.Val341Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All DMRTC2 variants
Likely benign 5
- p.Arg281Trp Single submitter
- p.Asp5Glu Single submitter
- p.Gly361= Single submitter
- p.Ser164Leu Single submitter
- p.Thr118Ala Single submitter
Uncertain significance 47
- p.Ala202Thr Single submitter ⚠
- p.Ala280Val Single submitter ⚠
- p.Ala295Thr Single submitter ⚠
- p.Ala307Ser Single submitter ⚠
- p.Ala350Val Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg251Cys Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg359Cys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg59Cys Single submitter
- p.Arg59His Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Asp24Glu Single submitter ⚠
- p.Asp303Val Single submitter ⚠
- p.Cys152Tyr Single submitter ⚠
- p.Cys344Arg Single submitter ⚠
- p.Gln94His Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.His11Arg Single submitter ⚠
- p.His180Gln Single submitter ⚠
- p.His356Arg Single submitter ⚠
- p.Leu324Phe Single submitter ⚠
- p.Lys115Arg Single submitter ⚠
- p.Met188Val Single submitter ⚠
- p.Phe208Val Single submitter ⚠
- p.Pro160Ser Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro206Ser Single submitter ⚠
- p.Pro264Ser Single submitter ⚠
- p.Pro266Leu Single submitter ⚠
- p.Pro316Arg Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Pro32Arg Single submitter ⚠
- p.Ser313Tyr Single submitter ⚠
- p.Ser362Cys Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val234Ala Single submitter ⚠
- p.Val299Met Single submitter ⚠
- p.Val341Leu Single submitter ⚠