DMTF1 — 85 ClinVar variants
All ClinVar germline DMTF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
1 Benign · 2 Likely benign · 82 Uncertain significance
Full DMTF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DMTF1 p.Ala308Thr Uncertain significance Single submitter
- DMTF1 p.Ala352Glu Uncertain significance Single submitter
- DMTF1 p.Ala357Thr Uncertain significance Single submitter
- DMTF1 p.Ala38Thr Uncertain significance Single submitter
- DMTF1 p.Ala38Val Uncertain significance Single submitter
- DMTF1 p.Ala548Thr Uncertain significance Single submitter
- DMTF1 p.Arg170His Uncertain significance Single submitter
- DMTF1 p.Arg170Ser Uncertain significance Single submitter
- DMTF1 p.Arg216Cys Uncertain significance Single submitter
- DMTF1 p.Arg283Thr Uncertain significance Single submitter
- DMTF1 p.Arg569Gly Uncertain significance Single submitter
- DMTF1 p.Asn113Asp Uncertain significance Single submitter
- DMTF1 p.Asn416His Uncertain significance Single submitter
- DMTF1 p.Asn422Ser Uncertain significance Single submitter
- DMTF1 p.Asp65Gly Uncertain significance Single submitter
- DMTF1 p.Asp692Gly Uncertain significance Single submitter
- DMTF1 p.Cys759Arg Uncertain significance Single submitter
- DMTF1 p.Gln23Glu Uncertain significance Single submitter
- DMTF1 p.Gln707Glu Uncertain significance Single submitter
- DMTF1 p.Glu14Ala Uncertain significance Single submitter
- DMTF1 p.Glu421Lys Uncertain significance Single submitter
- DMTF1 p.Glu99Gln Uncertain significance Single submitter
- DMTF1 p.Gly123Ala Uncertain significance Single submitter
- DMTF1 p.Gly314Val Uncertain significance Single submitter
- DMTF1 p.Gly405Ala Uncertain significance Single submitter
- DMTF1 p.Gly677Val Uncertain significance Single submitter
- DMTF1 p.His631Tyr Uncertain significance Single submitter
- DMTF1 p.His703Tyr Uncertain significance Single submitter
- DMTF1 p.Ile351Arg Uncertain significance Single submitter
- DMTF1 p.Ile595Thr Uncertain significance Single submitter
- DMTF1 p.Ile616Val Uncertain significance Single submitter
- DMTF1 p.Ile683Val Uncertain significance Single submitter
- DMTF1 p.Ile727Leu Uncertain significance Single submitter
- DMTF1 p.Leu122Val Uncertain significance Single submitter
- DMTF1 p.Leu29Val Uncertain significance Single submitter
- DMTF1 p.Leu742Ser Uncertain significance Single submitter
- DMTF1 p.Lys150Arg Uncertain significance Single submitter
- DMTF1 p.Lys414Asn Uncertain significance Single submitter
- DMTF1 p.Lys620Thr Uncertain significance Single submitter
- DMTF1 p.Met187Ile Uncertain significance Single submitter
- DMTF1 p.Met89Val Uncertain significance Single submitter
- DMTF1 p.Phe185Ser Uncertain significance Single submitter
- DMTF1 p.Phe612Cys Uncertain significance Single submitter
- DMTF1 p.Phe635Tyr Uncertain significance Single submitter
- DMTF1 p.Pro417Gln Uncertain significance Single submitter
- DMTF1 p.Pro619Arg Uncertain significance Single submitter
- DMTF1 p.Pro619Leu Uncertain significance Single submitter
- DMTF1 p.Pro666Ala Uncertain significance Single submitter
- DMTF1 p.Pro681Leu Uncertain significance Single submitter
- DMTF1 p.Ser72Ala Uncertain significance Single submitter
- DMTF1 p.Ser8Cys Uncertain significance Single submitter
- DMTF1 p.Thr611Ser Uncertain significance Single submitter
- DMTF1 p.Thr658Ser Uncertain significance Single submitter
- DMTF1 p.Thr92Ser Uncertain significance Single submitter
- DMTF1 p.Val19Leu Uncertain significance Single submitter
- DMTF1 p.Val753Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DMTF1 p.Arg239Trp Uncertain significance Single submitter
- DMTF1 p.Arg446Cys Uncertain significance Single submitter
- DMTF1 p.Asn28Ser Uncertain significance Single submitter
- DMTF1 p.Asp361Asn Uncertain significance Single submitter
- DMTF1 p.Gln438His Uncertain significance Single submitter
- DMTF1 p.Gln492His Uncertain significance Single submitter
- DMTF1 p.Gln564Pro Uncertain significance Single submitter
- DMTF1 p.Glu369Asp Uncertain significance Single submitter
- DMTF1 p.Glu495Gly Uncertain significance Single submitter
- DMTF1 p.Glu676Lys Uncertain significance Single submitter
- DMTF1 p.Glu94Lys Uncertain significance Single submitter
- DMTF1 p.Glu99Lys Uncertain significance Single submitter
- DMTF1 p.Ile348Leu Uncertain significance Single submitter
- DMTF1 p.Lys407Asn Uncertain significance Single submitter
- DMTF1 p.Pro702Leu Uncertain significance Single submitter
- DMTF1 p.Ser18Pro Uncertain significance Single submitter
- DMTF1 p.Ser2Asn Uncertain significance Single submitter
- DMTF1 p.Ser398Leu Uncertain significance Single submitter
- DMTF1 p.Ser744Asn Uncertain significance Single submitter
- DMTF1 p.Thr340Ile Uncertain significance Single submitter
- DMTF1 p.Thr483Lys Uncertain significance Single submitter
- DMTF1 p.Thr490Lys Uncertain significance Single submitter
- DMTF1 p.Thr524Ile Uncertain significance Single submitter
- DMTF1 p.Thr724Arg Uncertain significance Single submitter
- DMTF1 p.Trp371Cys Uncertain significance Single submitter
- DMTF1 p.Val19Met Uncertain significance Single submitter
All DMTF1 variants
Benign 1
- p.Thr590= Multiple submitters
Likely benign 2
- p.Ala38= Single submitter
- p.Val100Ile Single submitter
Uncertain significance 82
- p.Ala308Thr Single submitter ⚠
- p.Ala352Glu Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala38Val Single submitter ⚠
- p.Ala548Thr Single submitter ⚠
- p.Arg170His Single submitter ⚠
- p.Arg170Ser Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg283Thr Single submitter ⚠
- p.Arg446Cys Single submitter ⚠
- p.Arg569Gly Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asn28Ser Single submitter ⚠
- p.Asn416His Single submitter ⚠
- p.Asn422Ser Single submitter ⚠
- p.Asp361Asn Single submitter ⚠
- p.Asp65Gly Single submitter ⚠
- p.Asp692Gly Single submitter ⚠
- p.Cys759Arg Single submitter ⚠
- p.Gln23Glu Single submitter ⚠
- p.Gln438His Single submitter ⚠
- p.Gln492His Single submitter ⚠
- p.Gln564Pro Single submitter ⚠
- p.Gln707Glu Single submitter ⚠
- p.Glu14Ala Single submitter ⚠
- p.Glu369Asp Single submitter ⚠
- p.Glu421Lys Single submitter ⚠
- p.Glu495Gly Single submitter ⚠
- p.Glu676Lys Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Glu99Gln Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly123Ala Single submitter ⚠
- p.Gly314Val Single submitter ⚠
- p.Gly405Ala Single submitter ⚠
- p.Gly677Val Single submitter ⚠
- p.His631Tyr Single submitter ⚠
- p.His703Tyr Single submitter ⚠
- p.Ile348Leu Single submitter ⚠
- p.Ile351Arg Single submitter ⚠
- p.Ile595Thr Single submitter ⚠
- p.Ile616Val Single submitter ⚠
- p.Ile683Val Single submitter ⚠
- p.Ile727Leu Single submitter ⚠
- p.Leu122Val Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Leu742Ser Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys407Asn Single submitter ⚠
- p.Lys414Asn Single submitter ⚠
- p.Lys620Thr Single submitter ⚠
- p.Met187Ile Single submitter ⚠
- p.Met89Val Single submitter ⚠
- p.Phe185Ser Single submitter ⚠
- p.Phe612Cys Single submitter ⚠
- p.Phe635Tyr Single submitter ⚠
- p.Pro417Gln Single submitter ⚠
- p.Pro619Arg Single submitter ⚠
- p.Pro619Leu Single submitter ⚠
- p.Pro666Ala Single submitter ⚠
- p.Pro681Leu Single submitter ⚠
- p.Pro702Leu Single submitter ⚠
- p.Ser18Pro Single submitter ⚠
- p.Ser2Asn Single submitter ⚠
- p.Ser398Leu Single submitter ⚠
- p.Ser72Ala Single submitter ⚠
- p.Ser744Asn Single submitter ⚠
- p.Ser8Cys Single submitter ⚠
- p.Thr340Ile Single submitter ⚠
- p.Thr483Lys Single submitter ⚠
- p.Thr490Lys Single submitter ⚠
- p.Thr524Ile Single submitter ⚠
- p.Thr611Ser Single submitter ⚠
- p.Thr658Ser Single submitter ⚠
- p.Thr724Arg Single submitter ⚠
- p.Thr92Ser Single submitter ⚠
- p.Trp371Cys Single submitter ⚠
- p.Val19Leu Single submitter ⚠
- p.Val19Met Single submitter ⚠
- p.Val753Ile Single submitter ⚠