DMWD — 108 ClinVar variants
All ClinVar germline DMWD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
11 Benign · 1 Likely benign · 96 Uncertain significance
Full DMWD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DMWD p.Ala107Ser Uncertain significance Single submitter
- DMWD p.Ala14Ser Uncertain significance Single submitter
- DMWD p.Ala20Thr Uncertain significance Single submitter
- DMWD p.Ala250Thr Uncertain significance Single submitter
- DMWD p.Ala416Thr Uncertain significance Single submitter
- DMWD p.Ala6Gly Uncertain significance Single submitter
- DMWD p.Ala6Pro Uncertain significance Single submitter
- DMWD p.Arg297Gln Uncertain significance Single submitter
- DMWD p.Arg319Cys Uncertain significance Single submitter
- DMWD p.Arg363Gln Uncertain significance Single submitter
- DMWD p.Arg396Gln Uncertain significance Single submitter
- DMWD p.Arg44Ser Uncertain significance Single submitter
- DMWD p.Arg460His Uncertain significance Single submitter
- DMWD p.Arg542Cys Uncertain significance Single submitter
- DMWD p.Arg542His Uncertain significance Single submitter
- DMWD p.Arg570His Uncertain significance Single submitter
- DMWD p.Asp305Glu Uncertain significance Single submitter
- DMWD p.Glu111Gln Uncertain significance Single submitter
- DMWD p.Glu613Val Uncertain significance Single submitter
- DMWD p.Glu638Lys Uncertain significance Single submitter
- DMWD p.Glu641Gly Uncertain significance Single submitter
- DMWD p.Glu7Ala Uncertain significance Single submitter
- DMWD p.Gly123Val Uncertain significance Single submitter
- DMWD p.Gly394Ala Uncertain significance Single submitter
- DMWD p.Gly425Val Uncertain significance Single submitter
- DMWD p.Gly507Ser Uncertain significance Single submitter
- DMWD p.Gly566Ser Uncertain significance Single submitter
- DMWD p.Gly86Ala Uncertain significance Single submitter
- DMWD p.Ile180Val Uncertain significance Single submitter
- DMWD p.Ile625Val Uncertain significance Single submitter
- DMWD p.Leu450Phe Uncertain significance Single submitter
- DMWD p.Leu583Val Uncertain significance Single submitter
- DMWD p.Leu606Phe Uncertain significance Single submitter
- DMWD p.Pro104Arg Uncertain significance Single submitter
- DMWD p.Pro37Ser Uncertain significance Single submitter
- DMWD p.Pro420Ser Uncertain significance Single submitter
- DMWD p.Pro53Ala Uncertain significance Single submitter
- DMWD p.Pro585Leu Uncertain significance Single submitter
- DMWD p.Pro62Ala Uncertain significance Single submitter
- DMWD p.Pro80Arg Uncertain significance Single submitter
- DMWD p.Ser10Ala Uncertain significance Single submitter
- DMWD p.Ser145Thr Uncertain significance Single submitter
- DMWD p.Ser412Leu Uncertain significance Single submitter
- DMWD p.Ser648Gly Uncertain significance Single submitter
- DMWD p.Thr388Arg Uncertain significance Single submitter
- DMWD p.Thr468Pro Uncertain significance Single submitter
- DMWD p.Thr469Lys Uncertain significance Single submitter
- DMWD p.Thr516Ala Uncertain significance Single submitter
- DMWD p.Thr636Ala Uncertain significance Single submitter
- DMWD p.Thr640Ser Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- DMWD p.Ala109Val Uncertain significance Single submitter
- DMWD p.Ala14Val Uncertain significance Single submitter
- DMWD p.Ala15Pro Uncertain significance Single submitter
- DMWD p.Ala2Pro Uncertain significance Single submitter
- DMWD p.Ala3Val Uncertain significance Single submitter
- DMWD p.Ala408Val Uncertain significance Single submitter
- DMWD p.Ala416Val Uncertain significance Single submitter
- DMWD p.Ala473Thr Uncertain significance Single submitter
- DMWD p.Ala48Val Uncertain significance Single submitter
- DMWD p.Ala6Thr Uncertain significance Single submitter
- DMWD p.Arg143Leu Uncertain significance Single submitter
- DMWD p.Arg359Cys Uncertain significance Single submitter
- DMWD p.Arg458His Uncertain significance Single submitter
- DMWD p.Arg458Pro Uncertain significance Single submitter
- DMWD p.Arg460Cys Uncertain significance Single submitter
- DMWD p.Arg522His Uncertain significance Single submitter
- DMWD p.Arg531Gln Uncertain significance Single submitter
- DMWD p.Arg532Gln Uncertain significance Single submitter
- DMWD p.Arg534Gln Uncertain significance Single submitter
- DMWD p.Arg570Cys Uncertain significance Single submitter
- DMWD p.Asp150Glu Uncertain significance Single submitter
- DMWD p.Gln439His Uncertain significance Single submitter
- DMWD p.Glu178Lys Uncertain significance Single submitter
- DMWD p.Gly122Trp Uncertain significance Single submitter
- DMWD p.Gly394Arg Uncertain significance Single submitter
- DMWD p.Gly507Arg Uncertain significance Single submitter
- DMWD p.Gly515Val Uncertain significance Single submitter
- DMWD p.Leu36His Uncertain significance Single submitter
- DMWD p.Leu462Pro Uncertain significance Single submitter
- DMWD p.Pro251Leu Uncertain significance Single submitter
- DMWD p.Pro452Thr Uncertain significance Single submitter
- DMWD p.Pro454Leu Uncertain significance Single submitter
- DMWD p.Pro53Arg Uncertain significance Single submitter
- DMWD p.Pro53Leu Uncertain significance Single submitter
- DMWD p.Pro80Leu Uncertain significance Single submitter
- DMWD p.Ser106Asn Uncertain significance Single submitter
- DMWD p.Ser249Leu Uncertain significance Single submitter
- DMWD p.Ser270Gly Uncertain significance Single submitter
- DMWD p.Ser315Thr Uncertain significance Single submitter
- DMWD p.Ser412Trp Uncertain significance Single submitter
- DMWD p.Ser474Cys Uncertain significance Single submitter
- DMWD p.Ser69Phe Uncertain significance Single submitter
- DMWD p.Thr459Pro Uncertain significance Single submitter
- DMWD p.Thr469Met Uncertain significance Single submitter
- DMWD p.Val310Ile Uncertain significance Single submitter
- DMWD p.Val449Leu Uncertain significance Single submitter
-
DMWD p.Ala582Val
Benign
No assertion criteria
DMWD-related disorder
All DMWD variants
Benign 11
- p.Ala109= No assertion criteria DMWD-related disorder
- p.Ala472= No assertion criteria DMWD-related disorder
- p.Ala582Val No assertion criteria DMWD-related disorder ⚠
- p.Gly120= No assertion criteria DMWD-related disorder
- p.Gly415= No assertion criteria DMWD-related disorder
- p.Pro294= No assertion criteria DMWD-related disorder
- p.Pro417= No assertion criteria DMWD-related disorder
- p.Pro454= No assertion criteria DMWD-related disorder
- p.Pro471Ser No assertion criteria DMWD-related disorder
- p.Ser559= No assertion criteria DMWD-related disorder
- p.Thr527= No assertion criteria DMWD-related disorder
Likely benign 1
- p.His540= Single submitter
Uncertain significance 96
- p.Ala107Ser Single submitter ⚠
- p.Ala109Val Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala15Pro Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala2Pro Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala408Val Single submitter ⚠
- p.Ala416Thr Single submitter ⚠
- p.Ala416Val Single submitter ⚠
- p.Ala473Thr Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Ala6Gly Single submitter ⚠
- p.Ala6Pro Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg143Leu Single submitter ⚠
- p.Arg297Gln Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg359Cys Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Arg44Ser Single submitter ⚠
- p.Arg458His Single submitter ⚠
- p.Arg458Pro Single submitter ⚠
- p.Arg460Cys Single submitter ⚠
- p.Arg460His Single submitter ⚠
- p.Arg522His Single submitter ⚠
- p.Arg531Gln Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg542Cys Single submitter ⚠
- p.Arg542His Single submitter ⚠
- p.Arg570Cys Single submitter ⚠
- p.Arg570His Single submitter ⚠
- p.Asp150Glu Single submitter ⚠
- p.Asp305Glu Single submitter ⚠
- p.Gln439His Single submitter ⚠
- p.Glu111Gln Single submitter ⚠
- p.Glu178Lys Single submitter ⚠
- p.Glu613Val Single submitter ⚠
- p.Glu638Lys Single submitter ⚠
- p.Glu641Gly Single submitter ⚠
- p.Glu7Ala Single submitter ⚠
- p.Gly122Trp Single submitter ⚠
- p.Gly123Val Single submitter ⚠
- p.Gly394Ala Single submitter ⚠
- p.Gly394Arg Single submitter ⚠
- p.Gly425Val Single submitter ⚠
- p.Gly507Arg Single submitter ⚠
- p.Gly507Ser Single submitter ⚠
- p.Gly515Val Single submitter ⚠
- p.Gly566Ser Single submitter ⚠
- p.Gly86Ala Single submitter ⚠
- p.Ile180Val Single submitter ⚠
- p.Ile625Val Single submitter ⚠
- p.Leu36His Single submitter ⚠
- p.Leu450Phe Single submitter ⚠
- p.Leu462Pro Single submitter ⚠
- p.Leu583Val Single submitter ⚠
- p.Leu606Phe Single submitter ⚠
- p.Pro104Arg Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro420Ser Single submitter ⚠
- p.Pro452Thr Single submitter ⚠
- p.Pro454Leu Single submitter ⚠
- p.Pro53Ala Single submitter ⚠
- p.Pro53Arg Single submitter ⚠
- p.Pro53Leu Single submitter ⚠
- p.Pro585Leu Single submitter ⚠
- p.Pro62Ala Single submitter ⚠
- p.Pro80Arg Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser106Asn Single submitter ⚠
- p.Ser10Ala Single submitter ⚠
- p.Ser145Thr Single submitter ⚠
- p.Ser249Leu Single submitter ⚠
- p.Ser270Gly Single submitter ⚠
- p.Ser315Thr Single submitter ⚠
- p.Ser412Leu Single submitter ⚠
- p.Ser412Trp Single submitter ⚠
- p.Ser474Cys Single submitter ⚠
- p.Ser648Gly Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Thr388Arg Single submitter ⚠
- p.Thr459Pro Single submitter ⚠
- p.Thr468Pro Single submitter ⚠
- p.Thr469Lys Single submitter ⚠
- p.Thr469Met Single submitter ⚠
- p.Thr516Ala Single submitter ⚠
- p.Thr636Ala Single submitter ⚠
- p.Thr640Ser Single submitter ⚠
- p.Val310Ile Single submitter ⚠
- p.Val449Leu Single submitter ⚠