DNAAF10 — 52 ClinVar variants
All ClinVar germline DNAAF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Likely benign · 50 Uncertain significance
Full DNAAF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAAF10 p.Ala308Thr Uncertain significance Single submitter
- DNAAF10 p.Ala3Thr Uncertain significance Single submitter
- DNAAF10 p.Arg137Gln Uncertain significance Single submitter
- DNAAF10 p.Arg295Gln Uncertain significance Single submitter
- DNAAF10 p.Arg295Trp Uncertain significance Single submitter
- DNAAF10 p.Arg41Gln Uncertain significance Single submitter
- DNAAF10 p.Asn155Asp Uncertain significance Single submitter
- DNAAF10 p.Asp151Glu Uncertain significance Single submitter
- DNAAF10 p.Asp196Tyr Uncertain significance Single submitter
- DNAAF10 p.Cys24Ser Uncertain significance Single submitter
- DNAAF10 p.Cys29Tyr Uncertain significance Single submitter
- DNAAF10 p.Gln52His Uncertain significance Single submitter
- DNAAF10 p.Gln8Glu Uncertain significance Single submitter
- DNAAF10 p.Glu5Gly Uncertain significance Single submitter
- DNAAF10 p.Glu5Lys Uncertain significance Single submitter
- DNAAF10 p.Gly282Ser Uncertain significance Single submitter
- DNAAF10 p.His110Tyr Uncertain significance Single submitter
- DNAAF10 p.His245Arg Uncertain significance Single submitter
- DNAAF10 p.His285Asn Uncertain significance Single submitter
- DNAAF10 p.His53Tyr Uncertain significance Single submitter
- DNAAF10 p.Ile113Val Uncertain significance Single submitter
- DNAAF10 p.Ile192Val Uncertain significance Single submitter
- DNAAF10 p.Ile222Leu Uncertain significance Single submitter
- DNAAF10 p.Leu58Val Uncertain significance Single submitter
- DNAAF10 p.Lys226Glu Uncertain significance Single submitter
- DNAAF10 p.Lys297Arg Uncertain significance Single submitter
- DNAAF10 p.Lys298Glu Uncertain significance Single submitter
- DNAAF10 p.Lys6Asn Uncertain significance Single submitter
- DNAAF10 p.Phe195Val Uncertain significance Single submitter
- DNAAF10 p.Phe39Cys Uncertain significance Single submitter
- DNAAF10 p.Pro28Arg Uncertain significance Single submitter
- DNAAF10 p.Pro28Thr Uncertain significance Single submitter
- DNAAF10 p.Pro292Arg Uncertain significance Single submitter
- DNAAF10 p.Pro7Ser Uncertain significance Single submitter
- DNAAF10 p.Thr318Met Uncertain significance Single submitter
- DNAAF10 p.Val265Ile Uncertain significance Single submitter
- DNAAF10 p.Val351Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DNAAF10 p.Ala154Asp Uncertain significance Single submitter
- DNAAF10 p.Arg203Trp Uncertain significance Single submitter
- DNAAF10 p.Arg266Gln Uncertain significance Single submitter
- DNAAF10 p.Asp332Gly Uncertain significance Single submitter
- DNAAF10 p.His258Asn Uncertain significance Single submitter
- DNAAF10 p.Leu354Phe Uncertain significance Single submitter
- DNAAF10 p.Lys333Ile Uncertain significance Single submitter
- DNAAF10 p.Met224Ile Uncertain significance Single submitter
- DNAAF10 p.Met224Thr Uncertain significance Single submitter
- DNAAF10 p.Phe195Leu Uncertain significance Single submitter
- DNAAF10 p.Pro331Thr Uncertain significance Single submitter
- DNAAF10 p.Pro67Leu Uncertain significance Single submitter
All DNAAF10 variants
Likely benign 2
- p.Ile293Val Single submitter
- p.Val338Ile Single submitter
Uncertain significance 50
- p.Ala154Asp Single submitter ⚠
- p.Ala308Thr Single submitter ⚠
- p.Ala3Thr Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg266Gln Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg295Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Asn155Asp Single submitter ⚠
- p.Asp151Glu Single submitter ⚠
- p.Asp196Tyr Single submitter ⚠
- p.Asp332Gly Single submitter ⚠
- p.Cys24Ser Single submitter ⚠
- p.Cys29Tyr Single submitter ⚠
- p.Gln52His Single submitter ⚠
- p.Gln8Glu Single submitter ⚠
- p.Glu5Gly Single submitter ⚠
- p.Glu5Lys Single submitter ⚠
- p.Gly282Ser Single submitter ⚠
- p.Gly54Arg Single submitter
- p.His110Tyr Single submitter ⚠
- p.His245Arg Single submitter ⚠
- p.His258Asn Single submitter ⚠
- p.His285Asn Single submitter ⚠
- p.His53Tyr Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile192Val Single submitter ⚠
- p.Ile222Leu Single submitter ⚠
- p.Leu354Phe Single submitter ⚠
- p.Leu58Val Single submitter ⚠
- p.Lys226Glu Single submitter ⚠
- p.Lys297Arg Single submitter ⚠
- p.Lys298Glu Single submitter ⚠
- p.Lys333Ile Single submitter ⚠
- p.Lys6Asn Single submitter ⚠
- p.Met224Ile Single submitter ⚠
- p.Met224Thr Single submitter ⚠
- p.Phe195Leu Single submitter ⚠
- p.Phe195Val Single submitter ⚠
- p.Phe39Cys Single submitter ⚠
- p.Pro28Arg Single submitter ⚠
- p.Pro28Thr Single submitter ⚠
- p.Pro292Arg Single submitter ⚠
- p.Pro331Thr Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Thr318Met Single submitter ⚠
- p.Val265Ile Single submitter ⚠
- p.Val351Ile Single submitter ⚠