Sugi Variant

Sugi Variant/DNAAF4

DNAAF4 — 300 ClinVar variants

All ClinVar germline DNAAF4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →

21 Pathogenic · 7 Pathogenic/Likely pathogenic · 7 Likely pathogenic · 5 Conflicting · 44 Benign · 1 Benign/Likely benign · 90 Likely benign · 125 Uncertain significance

Full DNAAF4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 121

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 49

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 71

The independent predictors disagree with each other — read with care.

All DNAAF4 variants

Pathogenic 21

Pathogenic/Likely pathogenic 7

Likely pathogenic 7

Conflicting classifications of pathogenicity 5

Benign 44

Benign/Likely benign 1

Likely benign 90

Uncertain significance 125