DNAAF8 — 8 ClinVar variants
All ClinVar germline DNAAF8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
1 Likely benign · 7 Uncertain significance
Full DNAAF8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All DNAAF8 variants
Likely benign 1
- p.Lys341Glu Single submitter
Uncertain significance 7
- p.Arg145Ser Single submitter ⚠
- p.Asp218Asn Single submitter ⚠
- p.Gln108His Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Gly501Trp Single submitter ⚠
- p.Leu69Val Single submitter ⚠
- p.Met20Val Single submitter ⚠