Sugi Variant

Sugi Variant/DNAH2

DNAH2 — 791 ClinVar variants

All ClinVar germline DNAH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 422 flagged for review →

5 Pathogenic · 7 Likely pathogenic · 3 Conflicting · 55 Benign · 4 Benign/Likely benign · 97 Likely benign · 620 Uncertain significance

Full DNAH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 422

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 369

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 369

Predictors split 50

The independent predictors disagree with each other — read with care.

All DNAH2 variants

Pathogenic 5

Likely pathogenic 7

Conflicting classifications of pathogenicity 3

Benign 55

Benign/Likely benign 4

Likely benign 97

Uncertain significance 620

Showing the top 300 by review status; the full set is in the sitemap.