Sugi Variant

Sugi Variant/DNAH3

DNAH3 — 751 ClinVar variants

All ClinVar germline DNAH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 420 flagged for review →

1 Pathogenic · 3 Likely pathogenic · 5 Conflicting · 17 Benign · 1 Benign/Likely benign · 60 Likely benign · 664 Uncertain significance

Full DNAH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 420

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 383

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 383

Predictors split 34

The independent predictors disagree with each other — read with care.

All DNAH3 variants

Pathogenic 1

Likely pathogenic 3

Conflicting classifications of pathogenicity 5

Benign 17

Benign/Likely benign 1

Likely benign 60

Uncertain significance 664

Showing the top 300 by review status; the full set is in the sitemap.