Sugi Variant

Sugi Variant/DNAH6

DNAH6 — 742 ClinVar variants

All ClinVar germline DNAH6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 336 flagged for review →

1 Likely pathogenic · 154 Benign · 5 Benign/Likely benign · 47 Likely benign · 535 Uncertain significance

Full DNAH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 336

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 302

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 302

Predictors split 34

The independent predictors disagree with each other — read with care.

All DNAH6 variants

Likely pathogenic 1

  • p.Gly3575Arg Single submitter ciliary dyskinesia, primary, 45

Benign 154

Benign/Likely benign 5

Likely benign 47

Uncertain significance 535

Showing the top 300 by review status; the full set is in the sitemap.