DNAI3 — 137 ClinVar variants
All ClinVar germline DNAI3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
13 Benign · 9 Likely benign · 115 Uncertain significance
Full DNAI3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAI3 p.Ala215Pro Uncertain significance Single submitter
- DNAI3 p.Ala290Pro Uncertain significance Single submitter
- DNAI3 p.Arg11Pro Uncertain significance Single submitter
- DNAI3 p.Arg359Gln Uncertain significance Single submitter
- DNAI3 p.Arg433His Uncertain significance Single submitter
- DNAI3 p.Arg443Thr Uncertain significance Single submitter
- DNAI3 p.Arg658Gln Uncertain significance Single submitter
- DNAI3 p.Arg81Ser Uncertain significance Single submitter
- DNAI3 p.Arg824Cys Uncertain significance Single submitter
- DNAI3 p.Arg824Ser Uncertain significance Single submitter
- DNAI3 p.Asn622Ser Uncertain significance Single submitter
- DNAI3 p.Asp319Asn Uncertain significance Single submitter
- DNAI3 p.Asp549Gly Uncertain significance Single submitter
- DNAI3 p.Asp57Glu Uncertain significance Single submitter
- DNAI3 p.Asp741His Uncertain significance Single submitter
- DNAI3 p.Gln138Glu Uncertain significance Single submitter
- DNAI3 p.Gln201Arg Uncertain significance Single submitter
- DNAI3 p.Gln5Arg Uncertain significance Single submitter
- DNAI3 p.Gln679Glu Uncertain significance Single submitter
- DNAI3 p.Glu166Gly Uncertain significance Single submitter
- DNAI3 p.Glu545Asp Uncertain significance Single submitter
- DNAI3 p.Glu642Lys Uncertain significance Single submitter
- DNAI3 p.Gly370Ser Uncertain significance Single submitter
- DNAI3 p.Gly440Asp Uncertain significance Single submitter
- DNAI3 p.Gly498Asp Uncertain significance Single submitter
- DNAI3 p.Gly729Ala Uncertain significance Single submitter
- DNAI3 p.His676Arg Uncertain significance Single submitter
- DNAI3 p.Ile119Val Uncertain significance Single submitter
- DNAI3 p.Ile151Thr Uncertain significance Single submitter
- DNAI3 p.Ile169Thr Uncertain significance Single submitter
- DNAI3 p.Ile238Thr Uncertain significance Single submitter
- DNAI3 p.Ile285Met Uncertain significance Single submitter
- DNAI3 p.Ile422Leu Uncertain significance Single submitter
- DNAI3 p.Ile437Phe Uncertain significance Single submitter
- DNAI3 p.Ile466Val Uncertain significance Single submitter
- DNAI3 p.Ile525Met Uncertain significance Single submitter
- DNAI3 p.Ile74Thr Uncertain significance Single submitter
- DNAI3 p.Ile766Val Uncertain significance Single submitter
- DNAI3 p.Leu449Pro Uncertain significance Single submitter
- DNAI3 p.Leu559Val Uncertain significance Single submitter
- DNAI3 p.Lys142Glu Uncertain significance Single submitter
- DNAI3 p.Lys251Asn Uncertain significance Single submitter
- DNAI3 p.Lys480Asn Uncertain significance Single submitter
- DNAI3 p.Lys571Glu Uncertain significance Single submitter
- DNAI3 p.Lys625Glu Uncertain significance Single submitter
- DNAI3 p.Lys716Glu Uncertain significance Single submitter
- DNAI3 p.Lys833Glu Uncertain significance Single submitter
- DNAI3 p.Met297Ile Uncertain significance Single submitter
- DNAI3 p.Met424Ile Uncertain significance Single submitter
- DNAI3 p.Met762Val Uncertain significance Single submitter
- DNAI3 p.Pro612Leu Uncertain significance Single submitter
- DNAI3 p.Pro752Arg Uncertain significance Single submitter
- DNAI3 p.Pro89Thr Uncertain significance Single submitter
- DNAI3 p.Ser157Cys Uncertain significance Single submitter
- DNAI3 p.Ser23Asn Uncertain significance Single submitter
- DNAI3 p.Ser618Arg Uncertain significance Single submitter
- DNAI3 p.Ser666Ile Uncertain significance Single submitter
- DNAI3 p.Thr320Ile Uncertain significance Single submitter
- DNAI3 p.Thr329Pro Uncertain significance Single submitter
- DNAI3 p.Thr669Ser Uncertain significance Single submitter
- DNAI3 p.Thr677Ser Uncertain significance Single submitter
- DNAI3 p.Trp160Arg Uncertain significance Single submitter
- DNAI3 p.Trp344Arg Uncertain significance Single submitter
- DNAI3 p.Trp769Cys Uncertain significance Single submitter
- DNAI3 p.Tyr150Asp Uncertain significance Single submitter
- DNAI3 p.Tyr732Asp Uncertain significance Single submitter
- DNAI3 p.Val696Met Uncertain significance Single submitter
Predictors split 50
The independent predictors disagree with each other — read with care.
- DNAI3 p.Ala253Gly Uncertain significance Single submitter
- DNAI3 p.Ala353Val Uncertain significance Single submitter
- DNAI3 p.Arg187Gln Uncertain significance Single submitter
- DNAI3 p.Arg260Gly Uncertain significance Single submitter
- DNAI3 p.Arg55Gln Uncertain significance Single submitter
- DNAI3 p.Arg735Leu Uncertain significance Single submitter
- DNAI3 p.Arg79Leu Uncertain significance Single submitter
- DNAI3 p.Arg828Cys Uncertain significance Single submitter
- DNAI3 p.Arg828His Uncertain significance Single submitter
- DNAI3 p.Arg828Ser Uncertain significance Single submitter
- DNAI3 p.Asn127Ile Uncertain significance Single submitter
- DNAI3 p.Asp208His Uncertain significance Single submitter
- DNAI3 p.Asp330Asn Uncertain significance Single submitter
- DNAI3 p.Asp432Asn Uncertain significance Single submitter
- DNAI3 p.Asp432His Uncertain significance Single submitter
- DNAI3 p.Glu123Asp Uncertain significance Single submitter
- DNAI3 p.Glu140Ala Uncertain significance Single submitter
- DNAI3 p.Glu819Gly Uncertain significance Single submitter
- DNAI3 p.Gly124Asp Uncertain significance Single submitter
- DNAI3 p.Gly498Ala Uncertain significance Single submitter
- DNAI3 p.Gly673Val Uncertain significance Single submitter
- DNAI3 p.Gly734Ser Uncertain significance Single submitter
- DNAI3 p.His36Arg Uncertain significance Single submitter
- DNAI3 p.His430Pro Uncertain significance Single submitter
- DNAI3 p.His750Tyr Uncertain significance Single submitter
- DNAI3 p.Ile422Phe Uncertain significance Single submitter
- DNAI3 p.Ile770Phe Uncertain significance Single submitter
- DNAI3 p.Leu689Val Uncertain significance Single submitter
- DNAI3 p.Lys529Asn Uncertain significance Single submitter
- DNAI3 p.Lys652Arg Likely benign Single submitter
- DNAI3 p.Lys91Glu Uncertain significance Single submitter
- DNAI3 p.Phe401Leu Uncertain significance Single submitter
- DNAI3 p.Phe492Ser Uncertain significance Single submitter
- DNAI3 p.Pro236Ser Uncertain significance Single submitter
- DNAI3 p.Pro3Ala Benign Single submitter
- DNAI3 p.Pro407Leu Uncertain significance Single submitter
- DNAI3 p.Pro65Ser Uncertain significance Single submitter
- DNAI3 p.Ser383Thr Uncertain significance Single submitter
- DNAI3 p.Ser560Tyr Uncertain significance Single submitter
- DNAI3 p.Thr175Met Uncertain significance Single submitter
- DNAI3 p.Thr255Met Uncertain significance Single submitter
- DNAI3 p.Thr519Ile Uncertain significance Single submitter
- DNAI3 p.Thr690Met Uncertain significance Single submitter
- DNAI3 p.Thr761Ile Uncertain significance Single submitter
- DNAI3 p.Tyr128Asp Uncertain significance Single submitter
- DNAI3 p.Tyr40Cys Uncertain significance Single submitter
- DNAI3 p.Tyr684Asn Uncertain significance Single submitter
- DNAI3 p.Val105Leu Uncertain significance Single submitter
- DNAI3 p.Val423Ala Uncertain significance Single submitter
- DNAI3 p.Val821Gly Uncertain significance Single submitter
All DNAI3 variants
Benign 13
- c.1350+6C>A Multiple submitters
- p.Ala308Thr Multiple submitters
- p.Arg79= Multiple submitters
- p.Asp577= Multiple submitters
- p.Glu751= Multiple submitters
- p.His788= Multiple submitters
- p.His817= Multiple submitters
- p.Ile733= Multiple submitters
- c.2113-8G>T Single submitter
- c.740+9G>A Single submitter
- p.Arg15fs Single submitter
- p.Asp672= Single submitter
- p.Pro3Ala Single submitter ⚠
Likely benign 9
- p.Glu458= Multiple submitters
- c.1981+10G>C Single submitter
- p.Ala21Pro Single submitter
- p.Leu104= Single submitter
- p.Leu659Phe Single submitter
- p.Lys652Arg Single submitter ⚠
- p.Ser286= Single submitter
- p.Thr335Met Single submitter
- p.Val19= Single submitter
Uncertain significance 115
- p.Ala215Pro Single submitter ⚠
- p.Ala253Gly Single submitter ⚠
- p.Ala290Pro Single submitter ⚠
- p.Ala353Val Single submitter ⚠
- p.Arg11Pro Single submitter ⚠
- p.Arg187Gln Single submitter ⚠
- p.Arg260Gly Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg443Thr Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg658Gln Single submitter ⚠
- p.Arg735Leu Single submitter ⚠
- p.Arg79Leu Single submitter ⚠
- p.Arg81Ser Single submitter ⚠
- p.Arg824Cys Single submitter ⚠
- p.Arg824Ser Single submitter ⚠
- p.Arg828Cys Single submitter ⚠
- p.Arg828His Single submitter ⚠
- p.Arg828Ser Single submitter ⚠
- p.Asn127Ile Single submitter ⚠
- p.Asn622Ser Single submitter ⚠
- p.Asp208His Single submitter ⚠
- p.Asp319Asn Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Asp432Asn Single submitter ⚠
- p.Asp432His Single submitter ⚠
- p.Asp549Gly Single submitter ⚠
- p.Asp57Glu Single submitter ⚠
- p.Asp741His Single submitter ⚠
- p.Gln138Glu Single submitter ⚠
- p.Gln201Arg Single submitter ⚠
- p.Gln5Arg Single submitter ⚠
- p.Gln679Glu Single submitter ⚠
- p.Glu123Asp Single submitter ⚠
- p.Glu140Ala Single submitter ⚠
- p.Glu166Gly Single submitter ⚠
- p.Glu545Asp Single submitter ⚠
- p.Glu642Lys Single submitter ⚠
- p.Glu819Gly Single submitter ⚠
- p.Gly124Asp Single submitter ⚠
- p.Gly370Ser Single submitter ⚠
- p.Gly440Asp Single submitter ⚠
- p.Gly498Ala Single submitter ⚠
- p.Gly498Asp Single submitter ⚠
- p.Gly673Val Single submitter ⚠
- p.Gly729Ala Single submitter ⚠
- p.Gly734Ser Single submitter ⚠
- p.His36Arg Single submitter ⚠
- p.His430Pro Single submitter ⚠
- p.His676Arg Single submitter ⚠
- p.His750Tyr Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile151Thr Single submitter ⚠
- p.Ile169Thr Single submitter ⚠
- p.Ile238Thr Single submitter ⚠
- p.Ile285Met Single submitter ⚠
- p.Ile422Leu Single submitter ⚠
- p.Ile422Phe Single submitter ⚠
- p.Ile437Phe Single submitter ⚠
- p.Ile466Val Single submitter ⚠
- p.Ile525Met Single submitter ⚠
- p.Ile74Thr Single submitter ⚠
- p.Ile766Val Single submitter ⚠
- p.Ile770Phe Single submitter ⚠
- p.Leu449Pro Single submitter ⚠
- p.Leu559Val Single submitter ⚠
- p.Leu689Val Single submitter ⚠
- p.Lys142Glu Single submitter ⚠
- p.Lys251Asn Single submitter ⚠
- p.Lys480Asn Single submitter ⚠
- p.Lys529Asn Single submitter ⚠
- p.Lys571Glu Single submitter ⚠
- p.Lys625Glu Single submitter ⚠
- p.Lys716Glu Single submitter ⚠
- p.Lys833Glu Single submitter ⚠
- p.Lys91Glu Single submitter ⚠
- p.Met297Ile Single submitter ⚠
- p.Met424Ile Single submitter ⚠
- p.Met762Val Single submitter ⚠
- p.Phe401Leu Single submitter ⚠
- p.Phe492Ser Single submitter ⚠
- p.Pro236Ser Single submitter ⚠
- p.Pro407Leu Single submitter ⚠
- p.Pro612Leu Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Pro752Arg Single submitter ⚠
- p.Pro89Thr Single submitter ⚠
- p.Ser157Cys Single submitter ⚠
- p.Ser23Asn Single submitter ⚠
- p.Ser383Thr Single submitter ⚠
- p.Ser560Tyr Single submitter ⚠
- p.Ser618Arg Single submitter ⚠
- p.Ser666Ile Single submitter ⚠
- p.Thr175Met Single submitter ⚠
- p.Thr255Met Single submitter ⚠
- p.Thr320Ile Single submitter ⚠
- p.Thr329Pro Single submitter ⚠
- p.Thr519Ile Single submitter ⚠
- p.Thr669Ser Single submitter ⚠
- p.Thr677Ser Single submitter ⚠
- p.Thr690Met Single submitter ⚠
- p.Thr761Ile Single submitter ⚠
- p.Trp160Arg Single submitter ⚠
- p.Trp344Arg Single submitter ⚠
- p.Trp769Cys Single submitter ⚠
- p.Tyr128Asp Single submitter ⚠
- p.Tyr150Asp Single submitter ⚠
- p.Tyr40Cys Single submitter ⚠
- p.Tyr684Asn Single submitter ⚠
- p.Tyr732Asp Single submitter ⚠
- p.Val105Leu Single submitter ⚠
- p.Val423Ala Single submitter ⚠
- p.Val696Met Single submitter ⚠
- p.Val821Gly Single submitter ⚠