DNAI4 — 139 ClinVar variants
All ClinVar germline DNAI4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 130 flagged for review →
12 Likely benign · 127 Uncertain significance
Full DNAI4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 130
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAI4 p.Ala222Pro Uncertain significance Single submitter
- DNAI4 p.Ala328Ser Uncertain significance Single submitter
- DNAI4 p.Ala381Thr Uncertain significance Single submitter
- DNAI4 p.Ala463Glu Uncertain significance Single submitter
- DNAI4 p.Ala75Thr Uncertain significance Single submitter
- DNAI4 p.Ala84Glu Uncertain significance Single submitter
- DNAI4 p.Ala9Thr Uncertain significance Single submitter
- DNAI4 p.Arg12Pro Uncertain significance Single submitter
- DNAI4 p.Arg207Gln Uncertain significance Single submitter
- DNAI4 p.Arg209Ser Uncertain significance Single submitter
- DNAI4 p.Arg220Gly Uncertain significance Single submitter
- DNAI4 p.Arg220Lys Uncertain significance Single submitter
- DNAI4 p.Arg357Ile Uncertain significance Single submitter
- DNAI4 p.Arg409Trp Uncertain significance Single submitter
- DNAI4 p.Arg515Lys Uncertain significance Single submitter
- DNAI4 p.Arg617Gly Uncertain significance Single submitter
- DNAI4 p.Arg617Ile Uncertain significance Single submitter
- DNAI4 p.Asn110Lys Uncertain significance Single submitter
- DNAI4 p.Asn168Lys Uncertain significance Single submitter
- DNAI4 p.Asn58Lys Uncertain significance Single submitter
- DNAI4 p.Asn736Lys Uncertain significance Single submitter
- DNAI4 p.Asn787Tyr Uncertain significance Single submitter
- DNAI4 p.Asn790Lys Uncertain significance Single submitter
- DNAI4 p.Asp726Tyr Uncertain significance Single submitter
- DNAI4 p.Cys723Tyr Uncertain significance Single submitter
- DNAI4 p.Gln28Leu Uncertain significance Single submitter
- DNAI4 p.Gln52His Uncertain significance Single submitter
- DNAI4 p.Glu149Gly Uncertain significance Single submitter
- DNAI4 p.Glu465Asp Uncertain significance Single submitter
- DNAI4 p.Gly17Glu Uncertain significance Single submitter
- DNAI4 p.Gly516Val Uncertain significance Single submitter
- DNAI4 p.Gly538Arg Uncertain significance Single submitter
- DNAI4 p.Gly586Arg Uncertain significance Single submitter
- DNAI4 p.Gly604Val Uncertain significance Single submitter
- DNAI4 p.Gly646Ala Uncertain significance Single submitter
- DNAI4 p.Gly679Asp Uncertain significance Single submitter
- DNAI4 p.His390Tyr Uncertain significance Single submitter
- DNAI4 p.His401Pro Uncertain significance Single submitter
- DNAI4 p.His446Arg Uncertain significance Single submitter
- DNAI4 p.His777Arg Uncertain significance Single submitter
- DNAI4 p.Ile157Val Uncertain significance Single submitter
- DNAI4 p.Ile546Thr Uncertain significance Single submitter
- DNAI4 p.Ile594Val Uncertain significance Single submitter
- DNAI4 p.Ile612Val Uncertain significance Single submitter
- DNAI4 p.Ile730Thr Uncertain significance Single submitter
- DNAI4 p.Leu180Ser Uncertain significance Single submitter
- DNAI4 p.Leu627Pro Uncertain significance Single submitter
- DNAI4 p.Lys30Thr Uncertain significance Single submitter
- DNAI4 p.Lys620Gln Uncertain significance Single submitter
- DNAI4 p.Lys651Glu Uncertain significance Single submitter
- DNAI4 p.Phe24Leu Uncertain significance Single submitter
- DNAI4 p.Pro134Thr Uncertain significance Single submitter
- DNAI4 p.Pro359Thr Uncertain significance Single submitter
- DNAI4 p.Pro434Ala Uncertain significance Single submitter
- DNAI4 p.Pro43Ser Uncertain significance Single submitter
- DNAI4 p.Ser317Cys Uncertain significance Single submitter
- DNAI4 p.Ser490Arg Uncertain significance Single submitter
- DNAI4 p.Ser522Leu Uncertain significance Single submitter
- DNAI4 p.Ser613Pro Uncertain significance Single submitter
- DNAI4 p.Ser642Gly Uncertain significance Single submitter
- DNAI4 p.Thr138Ala Uncertain significance Single submitter
- DNAI4 p.Thr176Pro Uncertain significance Single submitter
- DNAI4 p.Thr2Lys Uncertain significance Single submitter
- DNAI4 p.Thr362Ala Uncertain significance Single submitter
- DNAI4 p.Thr638Ala Uncertain significance Single submitter
- DNAI4 p.Thr838Ser Uncertain significance Single submitter
- DNAI4 p.Trp19Cys Uncertain significance Single submitter
- DNAI4 p.Trp621Gly Uncertain significance Single submitter
- DNAI4 p.Trp712Cys Uncertain significance Single submitter
- DNAI4 p.Tyr505Ser Uncertain significance Single submitter
- DNAI4 p.Tyr761Cys Uncertain significance Single submitter
- DNAI4 p.Val440Ile Uncertain significance Single submitter
- DNAI4 p.Val44Leu Uncertain significance Single submitter
- DNAI4 p.Val572Asp Uncertain significance Single submitter
- DNAI4 p.Val572Ile Uncertain significance Single submitter
- DNAI4 p.Val827Leu Uncertain significance Single submitter
- DNAI4 p.Val91Ala Uncertain significance Single submitter
Predictors split 53
The independent predictors disagree with each other — read with care.
- DNAI4 p.Ala562Val Uncertain significance Single submitter
- DNAI4 p.Ala661Thr Uncertain significance Single submitter
- DNAI4 p.Ala789Val Uncertain significance Single submitter
- DNAI4 p.Arg424Cys Uncertain significance Single submitter
- DNAI4 p.Arg424His Uncertain significance Single submitter
- DNAI4 p.Arg531Cys Uncertain significance Single submitter
- DNAI4 p.Arg531His Uncertain significance Single submitter
- DNAI4 p.Arg634Gln Uncertain significance Single submitter
- DNAI4 p.Arg832Trp Uncertain significance Single submitter
- DNAI4 p.Asn283Ser Uncertain significance Single submitter
- DNAI4 p.Asn565Ser Uncertain significance Single submitter
- DNAI4 p.Asn571Tyr Uncertain significance Single submitter
- DNAI4 p.Asn693Lys Uncertain significance Single submitter
- DNAI4 p.Asp215Val Uncertain significance Single submitter
- DNAI4 p.Asp398Gly Uncertain significance Single submitter
- DNAI4 p.Asp398His Uncertain significance Single submitter
- DNAI4 p.Asp543Glu Uncertain significance Single submitter
- DNAI4 p.Asp576Gly Uncertain significance Single submitter
- DNAI4 p.Cys629Arg Uncertain significance Single submitter
- DNAI4 p.Gln417His Uncertain significance Single submitter
- DNAI4 p.Gln596Pro Uncertain significance Single submitter
- DNAI4 p.Gln660Pro Uncertain significance Single submitter
- DNAI4 p.Glu244Lys Uncertain significance Single submitter
- DNAI4 p.Glu388Gly Uncertain significance Single submitter
- DNAI4 p.Glu465Gln Likely benign Single submitter
- DNAI4 p.Glu595Asp Uncertain significance Single submitter
- DNAI4 p.Glu735Gln Uncertain significance Single submitter
- DNAI4 p.Gly602Arg Uncertain significance Single submitter
- DNAI4 p.Ile239Arg Uncertain significance Single submitter
- DNAI4 p.Ile309Lys Uncertain significance Single submitter
- DNAI4 p.Ile394Met Uncertain significance Single submitter
- DNAI4 p.Ile561Thr Uncertain significance Single submitter
- DNAI4 p.Ile675Met Uncertain significance Single submitter
- DNAI4 p.Lys687Arg Uncertain significance Single submitter
- DNAI4 p.Lys709Asn Uncertain significance Single submitter
- DNAI4 p.Met291Val Uncertain significance Single submitter
- DNAI4 p.Pro223Leu Uncertain significance Single submitter
- DNAI4 p.Pro469Ala Uncertain significance Single submitter
- DNAI4 p.Pro469Leu Uncertain significance Single submitter
- DNAI4 p.Pro587Ser Uncertain significance Single submitter
- DNAI4 p.Pro739Leu Uncertain significance Single submitter
- DNAI4 p.Pro825Ala Uncertain significance Single submitter
- DNAI4 p.Ser182Arg Uncertain significance Single submitter
- DNAI4 p.Ser619Ala Likely benign Single submitter
- DNAI4 p.Ser760Phe Uncertain significance Single submitter
- DNAI4 p.Ser842Phe Uncertain significance Single submitter
- DNAI4 p.Thr171Met Likely benign Single submitter
- DNAI4 p.Thr673Arg Uncertain significance Single submitter
- DNAI4 p.Tyr130Cys Uncertain significance Single submitter
- DNAI4 p.Tyr163Cys Uncertain significance Single submitter
- DNAI4 p.Val539Ile Uncertain significance Single submitter
- DNAI4 p.Val554Ile Uncertain significance Single submitter
- DNAI4 p.Val753Ile Uncertain significance Single submitter
All DNAI4 variants
Likely benign 12
- p.Ala13Thr Single submitter
- p.Ala641Thr Single submitter
- p.Gln338Arg Single submitter
- p.Glu465Gln Single submitter ⚠
- p.His446Leu Single submitter
- p.Leu38Pro Single submitter
- p.Lys399Arg Single submitter
- p.Phe24Ser Single submitter
- p.Pro107Thr Single submitter
- p.Ser619Ala Single submitter ⚠
- p.Thr114Ile Single submitter
- p.Thr171Met Single submitter ⚠
Uncertain significance 127
- p.Ala222Pro Single submitter ⚠
- p.Ala328Ser Single submitter ⚠
- p.Ala381Thr Single submitter ⚠
- p.Ala463Glu Single submitter ⚠
- p.Ala562Val Single submitter ⚠
- p.Ala661Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Ala789Val Single submitter ⚠
- p.Ala84Glu Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg12Pro Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg209Ser Single submitter ⚠
- p.Arg220Gly Single submitter ⚠
- p.Arg220Lys Single submitter ⚠
- p.Arg357Ile Single submitter ⚠
- p.Arg409Trp Single submitter ⚠
- p.Arg424Cys Single submitter ⚠
- p.Arg424His Single submitter ⚠
- p.Arg515Lys Single submitter ⚠
- p.Arg531Cys Single submitter ⚠
- p.Arg531His Single submitter ⚠
- p.Arg617Gly Single submitter ⚠
- p.Arg617Ile Single submitter ⚠
- p.Arg634Gln Single submitter ⚠
- p.Arg832Trp Single submitter ⚠
- p.Asn110Lys Single submitter ⚠
- p.Asn168Lys Single submitter ⚠
- p.Asn283Ser Single submitter ⚠
- p.Asn565Ser Single submitter ⚠
- p.Asn571Tyr Single submitter ⚠
- p.Asn58Lys Single submitter ⚠
- p.Asn693Lys Single submitter ⚠
- p.Asn736Lys Single submitter ⚠
- p.Asn787Tyr Single submitter ⚠
- p.Asn790Lys Single submitter ⚠
- p.Asp215Val Single submitter ⚠
- p.Asp398Gly Single submitter ⚠
- p.Asp398His Single submitter ⚠
- p.Asp543Glu Single submitter ⚠
- p.Asp576Gly Single submitter ⚠
- p.Asp726Tyr Single submitter ⚠
- p.Cys629Arg Single submitter ⚠
- p.Cys723Tyr Single submitter ⚠
- p.Gln28Leu Single submitter ⚠
- p.Gln417His Single submitter ⚠
- p.Gln52His Single submitter ⚠
- p.Gln596Pro Single submitter ⚠
- p.Gln660Pro Single submitter ⚠
- p.Glu149Gly Single submitter ⚠
- p.Glu244Lys Single submitter ⚠
- p.Glu388Gly Single submitter ⚠
- p.Glu465Asp Single submitter ⚠
- p.Glu595Asp Single submitter ⚠
- p.Glu735Gln Single submitter ⚠
- p.Gly17Glu Single submitter ⚠
- p.Gly516Val Single submitter ⚠
- p.Gly538Arg Single submitter ⚠
- p.Gly586Arg Single submitter ⚠
- p.Gly602Arg Single submitter ⚠
- p.Gly604Val Single submitter ⚠
- p.Gly646Ala Single submitter ⚠
- p.Gly679Asp Single submitter ⚠
- p.His390Tyr Single submitter ⚠
- p.His401Pro Single submitter ⚠
- p.His446Arg Single submitter ⚠
- p.His777Arg Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile239Arg Single submitter ⚠
- p.Ile309Lys Single submitter ⚠
- p.Ile394Met Single submitter ⚠
- p.Ile546Thr Single submitter ⚠
- p.Ile561Thr Single submitter ⚠
- p.Ile594Val Single submitter ⚠
- p.Ile612Val Single submitter ⚠
- p.Ile675Met Single submitter ⚠
- p.Ile730Thr Single submitter ⚠
- p.Leu180Ser Single submitter ⚠
- p.Leu627Pro Single submitter ⚠
- p.Lys30Thr Single submitter ⚠
- p.Lys620Gln Single submitter ⚠
- p.Lys651Glu Single submitter ⚠
- p.Lys687Arg Single submitter ⚠
- p.Lys709Asn Single submitter ⚠
- p.Met291Val Single submitter ⚠
- p.Phe24Leu Single submitter ⚠
- p.Pro134Thr Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro359Thr Single submitter ⚠
- p.Pro434Ala Single submitter ⚠
- p.Pro43Ser Single submitter ⚠
- p.Pro469Ala Single submitter ⚠
- p.Pro469Leu Single submitter ⚠
- p.Pro587Ser Single submitter ⚠
- p.Pro739Leu Single submitter ⚠
- p.Pro825Ala Single submitter ⚠
- p.Ser182Arg Single submitter ⚠
- p.Ser317Cys Single submitter ⚠
- p.Ser490Arg Single submitter ⚠
- p.Ser522Leu Single submitter ⚠
- p.Ser613Pro Single submitter ⚠
- p.Ser642Gly Single submitter ⚠
- p.Ser760Phe Single submitter ⚠
- p.Ser842Phe Single submitter ⚠
- p.Thr138Ala Single submitter ⚠
- p.Thr176Pro Single submitter ⚠
- p.Thr2Lys Single submitter ⚠
- p.Thr362Ala Single submitter ⚠
- p.Thr638Ala Single submitter ⚠
- p.Thr673Arg Single submitter ⚠
- p.Thr838Ser Single submitter ⚠
- p.Trp19Cys Single submitter ⚠
- p.Trp621Gly Single submitter ⚠
- p.Trp712Cys Single submitter ⚠
- p.Tyr130Cys Single submitter ⚠
- p.Tyr163Cys Single submitter ⚠
- p.Tyr505Ser Single submitter ⚠
- p.Tyr761Cys Single submitter ⚠
- p.Val440Ile Single submitter ⚠
- p.Val44Leu Single submitter ⚠
- p.Val539Ile Single submitter ⚠
- p.Val554Ile Single submitter ⚠
- p.Val572Asp Single submitter ⚠
- p.Val572Ile Single submitter ⚠
- p.Val753Ile Single submitter ⚠
- p.Val827Leu Single submitter ⚠
- p.Val91Ala Single submitter ⚠