DNAI7 — 103 ClinVar variants
All ClinVar germline DNAI7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
11 Likely benign · 92 Uncertain significance
Full DNAI7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAI7 p.Ala570Thr Uncertain significance Single submitter
- DNAI7 p.Ala65Thr Uncertain significance Single submitter
- DNAI7 p.Arg311Gly Uncertain significance Single submitter
- DNAI7 p.Arg348Gln Uncertain significance Single submitter
- DNAI7 p.Asn131Ser Uncertain significance Single submitter
- DNAI7 p.Asn702Asp Uncertain significance Single submitter
- DNAI7 p.Asn702His Uncertain significance Single submitter
- DNAI7 p.Asp253Asn Uncertain significance Single submitter
- DNAI7 p.Asp373His Uncertain significance Single submitter
- DNAI7 p.Cys541Arg Uncertain significance Single submitter
- DNAI7 p.Cys640Tyr Uncertain significance Single submitter
- DNAI7 p.Gln106Arg Uncertain significance Single submitter
- DNAI7 p.Gln327His Uncertain significance Single submitter
- DNAI7 p.Glu318Lys Uncertain significance Single submitter
- DNAI7 p.Glu355Lys Uncertain significance Single submitter
- DNAI7 p.Glu370Lys Uncertain significance Single submitter
- DNAI7 p.Glu573Ala Uncertain significance Single submitter
- DNAI7 p.Glu675Lys Uncertain significance Single submitter
- DNAI7 p.His270Tyr Uncertain significance Single submitter
- DNAI7 p.His679Gln Uncertain significance Single submitter
- DNAI7 p.Ile316Asn Uncertain significance Single submitter
- DNAI7 p.Ile554Val Uncertain significance Single submitter
- DNAI7 p.Ile590Val Uncertain significance Single submitter
- DNAI7 p.Leu194Pro Uncertain significance Single submitter
- DNAI7 p.Leu672Pro Uncertain significance Single submitter
- DNAI7 p.Lys22Arg Uncertain significance Single submitter
- DNAI7 p.Lys673Asn Uncertain significance Single submitter
- DNAI7 p.Lys673Thr Uncertain significance Single submitter
- DNAI7 p.Met350Leu Uncertain significance Single submitter
- DNAI7 p.Met47Arg Uncertain significance Single submitter
- DNAI7 p.Met685Thr Uncertain significance Single submitter
- DNAI7 p.Met685Val Uncertain significance Single submitter
- DNAI7 p.Phe374Ile Uncertain significance Single submitter
- DNAI7 p.Phe374Leu Uncertain significance Single submitter
- DNAI7 p.Pro372Leu Uncertain significance Single submitter
- DNAI7 p.Pro457Ser Uncertain significance Single submitter
- DNAI7 p.Pro644Ser Uncertain significance Single submitter
- DNAI7 p.Ser358Ala Uncertain significance Single submitter
- DNAI7 p.Thr133Ser Uncertain significance Single submitter
- DNAI7 p.Thr386Ile Uncertain significance Single submitter
- DNAI7 p.Thr387Ile Uncertain significance Single submitter
- DNAI7 p.Thr428Ser Uncertain significance Single submitter
- DNAI7 p.Trp561Arg Uncertain significance Single submitter
- DNAI7 p.Trp646Arg Uncertain significance Single submitter
- DNAI7 p.Tyr42His Uncertain significance Single submitter
- DNAI7 p.Val332Met Uncertain significance Single submitter
- DNAI7 p.Val391Ile Uncertain significance Single submitter
- DNAI7 p.Val588Ile Uncertain significance Single submitter
Predictors split 43
The independent predictors disagree with each other — read with care.
- DNAI7 p.Arg235Gly Uncertain significance Single submitter
- DNAI7 p.Arg39Cys Uncertain significance Single submitter
- DNAI7 p.Arg54Gln Uncertain significance Single submitter
- DNAI7 p.Arg62Pro Uncertain significance Single submitter
- DNAI7 p.Asn207Tyr Uncertain significance Single submitter
- DNAI7 p.Asp108Gly Uncertain significance Single submitter
- DNAI7 p.Asp202His Uncertain significance Single submitter
- DNAI7 p.Gln604His Uncertain significance Single submitter
- DNAI7 p.Glu34Lys Uncertain significance Single submitter
- DNAI7 p.Glu538Gly Uncertain significance Single submitter
- DNAI7 p.Glu664Lys Uncertain significance Single submitter
- DNAI7 p.Glu74Asp Uncertain significance Single submitter
- DNAI7 p.Glu82Lys Uncertain significance Single submitter
- DNAI7 p.His393Leu Uncertain significance Single submitter
- DNAI7 p.His503Tyr Uncertain significance Single submitter
- DNAI7 p.Ile175Leu Uncertain significance Single submitter
- DNAI7 p.Ile254Thr Uncertain significance Single submitter
- DNAI7 p.Ile441Thr Uncertain significance Single submitter
- DNAI7 p.Ile55Thr Uncertain significance Single submitter
- DNAI7 p.Leu178Val Uncertain significance Single submitter
- DNAI7 p.Leu21Met Uncertain significance Single submitter
- DNAI7 p.Leu225Phe Uncertain significance Single submitter
- DNAI7 p.Leu498Met Uncertain significance Single submitter
- DNAI7 p.Leu50Pro Uncertain significance Single submitter
- DNAI7 p.Leu648Phe Uncertain significance Single submitter
- DNAI7 p.Leu81Ser Uncertain significance Single submitter
- DNAI7 p.Lys13Asn Uncertain significance Single submitter
- DNAI7 p.Met208Thr Uncertain significance Single submitter
- DNAI7 p.Met650Lys Uncertain significance Single submitter
- DNAI7 p.Met650Thr Uncertain significance Single submitter
- DNAI7 p.Pro426Leu Uncertain significance Single submitter
- DNAI7 p.Pro507Ala Uncertain significance Single submitter
- DNAI7 p.Thr121Met Uncertain significance Single submitter
- DNAI7 p.Thr218Ile Uncertain significance Single submitter
- DNAI7 p.Thr487Ile Uncertain significance Single submitter
- DNAI7 p.Thr497Ile Uncertain significance Single submitter
- DNAI7 p.Tyr263His Uncertain significance Single submitter
- DNAI7 p.Tyr392His Uncertain significance Single submitter
- DNAI7 p.Val115Ala Uncertain significance Single submitter
- DNAI7 p.Val458Gly Uncertain significance Single submitter
- DNAI7 p.Val459Ala Uncertain significance Single submitter
- DNAI7 p.Val628Phe Uncertain significance Single submitter
- DNAI7 p.Val629Leu Uncertain significance Single submitter
All DNAI7 variants
Likely benign 11
- c.1894-10_1894-3dup Single submitter
- c.1894-3_1894-2insTTTTTTTTTTTTTTTTTTTTTTTTT Single submitter
- c.1894-3_1894-2insTTTTTTTTTTTTTTTTTTTTTTTTTT Single submitter
- c.1894-3_1894-2insTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT Single submitter
- p.Ile168Val Single submitter
- p.Ser267= Single submitter
- p.Val143Leu Single submitter
- p.Val211Ile Single submitter
- p.Val629Ile Single submitter
- p.Val632Met Single submitter
- p.Val698Ile Single submitter
Uncertain significance 92
- p.Ala570Thr Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg235Gly Single submitter ⚠
- p.Arg311Gly Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg62Pro Single submitter ⚠
- p.Asn131Ser Single submitter ⚠
- p.Asn207Tyr Single submitter ⚠
- p.Asn702Asp Single submitter ⚠
- p.Asn702His Single submitter ⚠
- p.Asp108Gly Single submitter ⚠
- p.Asp202His Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Asp373His Single submitter ⚠
- p.Cys541Arg Single submitter ⚠
- p.Cys640Tyr Single submitter ⚠
- p.Gln106Arg Single submitter ⚠
- p.Gln327His Single submitter ⚠
- p.Gln604His Single submitter ⚠
- p.Glu318Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.Glu370Lys Single submitter ⚠
- p.Glu538Gly Single submitter ⚠
- p.Glu573Ala Single submitter ⚠
- p.Glu664Lys Single submitter ⚠
- p.Glu675Lys Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Glu82Lys Single submitter ⚠
- p.His270Tyr Single submitter ⚠
- p.His393Leu Single submitter ⚠
- p.His503Tyr Single submitter ⚠
- p.His679Gln Single submitter ⚠
- p.Ile175Leu Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Ile316Asn Single submitter ⚠
- p.Ile441Thr Single submitter ⚠
- p.Ile554Val Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Ile590Val Single submitter ⚠
- p.Leu178Val Single submitter ⚠
- p.Leu194Pro Single submitter ⚠
- p.Leu21Met Single submitter ⚠
- p.Leu225Phe Single submitter ⚠
- p.Leu498Met Single submitter ⚠
- p.Leu50Pro Single submitter ⚠
- p.Leu648Phe Single submitter ⚠
- p.Leu672Pro Single submitter ⚠
- p.Leu81Ser Single submitter ⚠
- p.Lys13Asn Single submitter ⚠
- p.Lys22Arg Single submitter ⚠
- p.Lys4Glu Single submitter
- p.Lys673Asn Single submitter ⚠
- p.Lys673Thr Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Met350Leu Single submitter ⚠
- p.Met47Arg Single submitter ⚠
- p.Met650Lys Single submitter ⚠
- p.Met650Thr Single submitter ⚠
- p.Met685Thr Single submitter ⚠
- p.Met685Val Single submitter ⚠
- p.Phe374Ile Single submitter ⚠
- p.Phe374Leu Single submitter ⚠
- p.Pro372Leu Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro457Ser Single submitter ⚠
- p.Pro507Ala Single submitter ⚠
- p.Pro644Ser Single submitter ⚠
- p.Ser358Ala Single submitter ⚠
- p.Thr121Met Single submitter ⚠
- p.Thr133Ser Single submitter ⚠
- p.Thr218Ile Single submitter ⚠
- p.Thr386Ile Single submitter ⚠
- p.Thr387Ile Single submitter ⚠
- p.Thr428Ser Single submitter ⚠
- p.Thr487Ile Single submitter ⚠
- p.Thr497Ile Single submitter ⚠
- p.Trp561Arg Single submitter ⚠
- p.Trp646Arg Single submitter ⚠
- p.Tyr263His Single submitter ⚠
- p.Tyr392His Single submitter ⚠
- p.Tyr42His Single submitter ⚠
- p.Val115Ala Single submitter ⚠
- p.Val332Met Single submitter ⚠
- p.Val391Ile Single submitter ⚠
- p.Val458Gly Single submitter ⚠
- p.Val459Ala Single submitter ⚠
- p.Val588Ile Single submitter ⚠
- p.Val628Phe Single submitter ⚠
- p.Val629Leu Single submitter ⚠