DNAJA1 — 33 ClinVar variants
All ClinVar germline DNAJA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
33 Uncertain significance
Full DNAJA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJA1 p.Ala380Val Uncertain significance Single submitter
- DNAJA1 p.Arg254Gln Uncertain significance Single submitter
- DNAJA1 p.Arg312His Uncertain significance Single submitter
- DNAJA1 p.Arg374His Uncertain significance Single submitter
- DNAJA1 p.Asp238Gly Uncertain significance Single submitter
- DNAJA1 p.Asp263Asn Uncertain significance Single submitter
- DNAJA1 p.Glu357Asp Uncertain significance Single submitter
- DNAJA1 p.Ile160Val Uncertain significance Single submitter
- DNAJA1 p.Ile277Val Uncertain significance Single submitter
- DNAJA1 p.Ile300Thr Uncertain significance Single submitter
- DNAJA1 p.Ile322Val Uncertain significance Single submitter
- DNAJA1 p.Leu115Val Uncertain significance Single submitter
- DNAJA1 p.Lys301Asn Uncertain significance Single submitter
- DNAJA1 p.Met85Ile Uncertain significance Single submitter
- DNAJA1 p.Pro276Ser Uncertain significance Single submitter
- DNAJA1 p.Pro291Ser Uncertain significance Single submitter
- DNAJA1 p.Pro347Thr Uncertain significance Single submitter
- DNAJA1 p.Ser56Phe Uncertain significance Single submitter
- DNAJA1 p.Tyr64His Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DNAJA1 p.Arg372Gly Uncertain significance Single submitter
- DNAJA1 p.Arg373Trp Uncertain significance Single submitter
- DNAJA1 p.Arg374Cys Uncertain significance Single submitter
- DNAJA1 p.Asp365Ala Uncertain significance Single submitter
- DNAJA1 p.Glu41Asp Uncertain significance Single submitter
- DNAJA1 p.Glu41Gln Uncertain significance Single submitter
- DNAJA1 p.Ile165Leu Uncertain significance Single submitter
- DNAJA1 p.Lys344Ile Uncertain significance Single submitter
- DNAJA1 p.Phe259Cys Uncertain significance Single submitter
- DNAJA1 p.Phe259Ser Uncertain significance Single submitter
- DNAJA1 p.Phe81Val Uncertain significance Single submitter
- DNAJA1 p.Thr18Ile Uncertain significance Single submitter
All DNAJA1 variants
Uncertain significance 33
- p.Ala380Val Single submitter ⚠
- p.Arg254Gln Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg372Gly Single submitter ⚠
- p.Arg373Trp Single submitter ⚠
- p.Arg374Cys Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Asp238Gly Single submitter ⚠
- p.Asp263Asn Single submitter ⚠
- p.Asp365Ala Single submitter ⚠
- p.Glu357Asp Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Glu41Gln Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile165Leu Single submitter ⚠
- p.Ile277Val Single submitter ⚠
- p.Ile300Thr Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu258Ile Single submitter
- p.Lys301Asn Single submitter ⚠
- p.Lys344Ile Single submitter ⚠
- p.Met85Ile Single submitter ⚠
- p.Met85Val Single submitter
- p.Phe259Cys Single submitter ⚠
- p.Phe259Ser Single submitter ⚠
- p.Phe81Val Single submitter ⚠
- p.Pro276Ser Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Pro347Thr Single submitter ⚠
- p.Ser56Phe Single submitter ⚠
- p.Thr18Ile Single submitter ⚠
- p.Tyr64His Single submitter ⚠