DNAJA3 — 104 ClinVar variants
All ClinVar germline DNAJA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
6 Likely benign · 98 Uncertain significance
Full DNAJA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJA3 p.Ala21Thr Uncertain significance Single submitter
- DNAJA3 p.Ala357Thr Uncertain significance Single submitter
- DNAJA3 p.Ala455Thr Uncertain significance Single submitter
- DNAJA3 p.Ala49Thr Uncertain significance Single submitter
- DNAJA3 p.Arg102Pro Uncertain significance Single submitter
- DNAJA3 p.Arg272Cys Uncertain significance Single submitter
- DNAJA3 p.Arg419Gln Uncertain significance Single submitter
- DNAJA3 p.Arg64Gly Uncertain significance Single submitter
- DNAJA3 p.Asn439Ser Uncertain significance Single submitter
- DNAJA3 p.Asp314Gly Uncertain significance Single submitter
- DNAJA3 p.Asp466Asn Uncertain significance Single submitter
- DNAJA3 p.Cys55Trp Uncertain significance Single submitter
- DNAJA3 p.Cys5Phe Uncertain significance Single submitter
- DNAJA3 p.Cys5Trp Uncertain significance Single submitter
- DNAJA3 p.Gln202Glu Uncertain significance Single submitter
- DNAJA3 p.Gln334Lys Uncertain significance Single submitter
- DNAJA3 p.Glu148Lys Uncertain significance Single submitter
- DNAJA3 p.Glu245Lys Uncertain significance Single submitter
- DNAJA3 p.Glu92Lys Uncertain significance Single submitter
- DNAJA3 p.Gly247Arg Uncertain significance Single submitter
- DNAJA3 p.Gly260Val Uncertain significance Single submitter
- DNAJA3 p.Gly33Val Uncertain significance Single submitter
- DNAJA3 p.Ile22Thr Uncertain significance Single submitter
- DNAJA3 p.Ile264Asn Uncertain significance Single submitter
- DNAJA3 p.Ile284Val Uncertain significance Single submitter
- DNAJA3 p.Ile354Val Uncertain significance Single submitter
- DNAJA3 p.Leu443Phe Uncertain significance Single submitter
- DNAJA3 p.Leu61Val Uncertain significance Single submitter
- DNAJA3 p.Lys476Arg Uncertain significance Single submitter
- DNAJA3 p.Met271Thr Uncertain significance Single submitter
- DNAJA3 p.Met388Ile Uncertain significance Single submitter
- DNAJA3 p.Met451Thr Uncertain significance Single submitter
- DNAJA3 p.Phe186Ser Uncertain significance Single submitter
- DNAJA3 p.Pro164His Uncertain significance Single submitter
- DNAJA3 p.Pro17Thr Uncertain significance Single submitter
- DNAJA3 p.Pro20Ser Uncertain significance Single submitter
- DNAJA3 p.Pro378Ala Uncertain significance Single submitter
- DNAJA3 p.Pro57Leu Uncertain significance Single submitter
- DNAJA3 p.Ser40Arg Uncertain significance Single submitter
- DNAJA3 p.Ser6Phe Uncertain significance Single submitter
- DNAJA3 p.Thr53Ser Uncertain significance Single submitter
- DNAJA3 p.Thr7Ala Uncertain significance Single submitter
- DNAJA3 p.Trp38Arg Uncertain significance Single submitter
- DNAJA3 p.Val441Ile Uncertain significance Single submitter
- DNAJA3 p.Ala428Thr Uncertain significance No assertion criteria
- DNAJA3 p.Arg151Thr Uncertain significance No assertion criteria
Predictors split 54
The independent predictors disagree with each other — read with care.
- DNAJA3 p.Ala112Val Uncertain significance Single submitter
- DNAJA3 p.Ala344Thr Uncertain significance Single submitter
- DNAJA3 p.Ala355Val Uncertain significance Single submitter
- DNAJA3 p.Ala365Thr Uncertain significance Single submitter
- DNAJA3 p.Ala3Val Uncertain significance Single submitter
- DNAJA3 p.Arg238His Uncertain significance Single submitter
- DNAJA3 p.Arg272His Uncertain significance Single submitter
- DNAJA3 p.Arg281Cys Uncertain significance Single submitter
- DNAJA3 p.Arg31Lys Uncertain significance Single submitter
- DNAJA3 p.Arg387Gln Uncertain significance Single submitter
- DNAJA3 p.Arg419Trp Uncertain significance Single submitter
- DNAJA3 p.Arg41Cys Uncertain significance Single submitter
- DNAJA3 p.Arg461His Uncertain significance Single submitter
- DNAJA3 p.Arg4Gln Uncertain significance Single submitter
- DNAJA3 p.Arg4Trp Uncertain significance Single submitter
- DNAJA3 p.Arg8Gly Uncertain significance Single submitter
- DNAJA3 p.Gln153Arg Uncertain significance Single submitter
- DNAJA3 p.Gln384Leu Uncertain significance Single submitter
- DNAJA3 p.Glu184Asp Uncertain significance Single submitter
- DNAJA3 p.Glu370Gly Uncertain significance Single submitter
- DNAJA3 p.Glu468Lys Uncertain significance Single submitter
- DNAJA3 p.Gly168Ser Likely benign Single submitter
- DNAJA3 p.Gly343Ser Uncertain significance Single submitter
- DNAJA3 p.Gly400Ser Uncertain significance Single submitter
- DNAJA3 p.Gly440Ser Uncertain significance Single submitter
- DNAJA3 p.Gly447Asp Uncertain significance Single submitter
- DNAJA3 p.Leu10Trp Uncertain significance Single submitter
- DNAJA3 p.Lys302Met Uncertain significance Single submitter
- DNAJA3 p.Met261Thr Uncertain significance Single submitter
- DNAJA3 p.Pro101Leu Uncertain significance Single submitter
- DNAJA3 p.Pro178Ala Uncertain significance Single submitter
- DNAJA3 p.Pro288Leu Uncertain significance Single submitter
- DNAJA3 p.Pro377Thr Uncertain significance Single submitter
- DNAJA3 p.Pro46Leu Uncertain significance Single submitter
- DNAJA3 p.Pro65Leu Uncertain significance Single submitter
- DNAJA3 p.Ser169Cys Uncertain significance Single submitter
- DNAJA3 p.Ser195Cys Uncertain significance Single submitter
- DNAJA3 p.Ser197Ala Uncertain significance Single submitter
- DNAJA3 p.Ser422Arg Uncertain significance Single submitter
- DNAJA3 p.Ser426Asn Uncertain significance Single submitter
- DNAJA3 p.Ser426Thr Uncertain significance Single submitter
- DNAJA3 p.Ser454Tyr Uncertain significance Single submitter
- DNAJA3 p.Ser50Phe Uncertain significance Single submitter
- DNAJA3 p.Ser68Asn Uncertain significance Single submitter
- DNAJA3 p.Ser6Pro Uncertain significance Single submitter
- DNAJA3 p.Ser82Phe Likely benign Single submitter
- DNAJA3 p.Thr274Met Uncertain significance Single submitter
- DNAJA3 p.Thr371Met Uncertain significance Single submitter
- DNAJA3 p.Thr53Ile Uncertain significance Single submitter
- DNAJA3 p.Thr85Pro Uncertain significance Single submitter
- DNAJA3 p.Trp9Arg Uncertain significance Single submitter
- DNAJA3 p.Tyr369His Uncertain significance Single submitter
- DNAJA3 p.Tyr401His Uncertain significance Single submitter
- DNAJA3 p.Val45Ile Uncertain significance Single submitter
All DNAJA3 variants
Likely benign 6
- p.Cys55Arg Single submitter
- p.Glu32Gly Single submitter
- p.Gly168Ser Single submitter ⚠
- p.Ile286Val Single submitter
- p.Ser23Leu Single submitter
- p.Ser82Phe Single submitter ⚠
Uncertain significance 98
- p.Ala112Val Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala344Thr Single submitter ⚠
- p.Ala355Val Single submitter ⚠
- p.Ala357Thr Single submitter ⚠
- p.Ala365Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala455Thr Single submitter ⚠
- p.Ala49Thr Single submitter ⚠
- p.Arg102Pro Single submitter ⚠
- p.Arg238His Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg281Cys Single submitter ⚠
- p.Arg31Lys Single submitter ⚠
- p.Arg387Gln Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg419Trp Single submitter ⚠
- p.Arg41Cys Single submitter ⚠
- p.Arg461His Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg4Trp Single submitter ⚠
- p.Arg64Gly Single submitter ⚠
- p.Arg8Gly Single submitter ⚠
- p.Asn439Ser Single submitter ⚠
- p.Asp314Gly Single submitter ⚠
- p.Asp466Asn Single submitter ⚠
- p.Cys55Trp Single submitter ⚠
- p.Cys5Phe Single submitter ⚠
- p.Cys5Trp Single submitter ⚠
- p.Gln153Arg Single submitter ⚠
- p.Gln202Glu Single submitter ⚠
- p.Gln334Lys Single submitter ⚠
- p.Gln384Leu Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu184Asp Single submitter ⚠
- p.Glu245Lys Single submitter ⚠
- p.Glu370Gly Single submitter ⚠
- p.Glu468Lys Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly247Arg Single submitter ⚠
- p.Gly260Val Single submitter ⚠
- p.Gly33Val Single submitter ⚠
- p.Gly343Ser Single submitter ⚠
- p.Gly400Ser Single submitter ⚠
- p.Gly440Ser Single submitter ⚠
- p.Gly447Asp Single submitter ⚠
- p.Ile22Thr Single submitter ⚠
- p.Ile264Asn Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Ile354Val Single submitter ⚠
- p.Leu10Trp Single submitter ⚠
- p.Leu443Phe Single submitter ⚠
- p.Leu61Val Single submitter ⚠
- p.Lys302Met Single submitter ⚠
- p.Lys476Arg Single submitter ⚠
- p.Met261Thr Single submitter ⚠
- p.Met271Thr Single submitter ⚠
- p.Met388Ile Single submitter ⚠
- p.Met451Thr Single submitter ⚠
- p.Phe186Ser Single submitter ⚠
- p.Pro101Leu Single submitter ⚠
- p.Pro164His Single submitter ⚠
- p.Pro178Ala Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Pro288Leu Single submitter ⚠
- p.Pro377Thr Single submitter ⚠
- p.Pro378Ala Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Ser169Cys Single submitter ⚠
- p.Ser195Cys Single submitter ⚠
- p.Ser197Ala Single submitter ⚠
- p.Ser40Arg Single submitter ⚠
- p.Ser422Arg Single submitter ⚠
- p.Ser426Asn Single submitter ⚠
- p.Ser426Thr Single submitter ⚠
- p.Ser454Tyr Single submitter ⚠
- p.Ser50Phe Single submitter ⚠
- p.Ser68Asn Single submitter ⚠
- p.Ser6Phe Single submitter ⚠
- p.Ser6Pro Single submitter ⚠
- p.Thr274Met Single submitter ⚠
- p.Thr371Met Single submitter ⚠
- p.Thr53Ile Single submitter ⚠
- p.Thr53Ser Single submitter ⚠
- p.Thr7Ala Single submitter ⚠
- p.Thr85Pro Single submitter ⚠
- p.Trp38Arg Single submitter ⚠
- p.Trp9Arg Single submitter ⚠
- p.Tyr369His Single submitter ⚠
- p.Tyr401His Single submitter ⚠
- p.Val441Ile Single submitter ⚠
- p.Val45Ile Single submitter ⚠
- p.Ala428Thr No assertion criteria ⚠
- p.Arg151Thr No assertion criteria ⚠