DNAJB1 — 60 ClinVar variants
All ClinVar germline DNAJB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
3 Benign · 1 Likely benign · 56 Uncertain significance
Full DNAJB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB1 p.Ala265Val Uncertain significance Single submitter
- DNAJB1 p.Arg119Gln Uncertain significance Single submitter
- DNAJB1 p.Arg30Cys Uncertain significance Single submitter
- DNAJB1 p.Asn143Ser Uncertain significance Single submitter
- DNAJB1 p.Asn229Ser Uncertain significance Single submitter
- DNAJB1 p.Asn245Ser Uncertain significance Single submitter
- DNAJB1 p.Asn86Ser Uncertain significance Single submitter
- DNAJB1 p.Gln226His Uncertain significance Single submitter
- DNAJB1 p.Gly14Asp Uncertain significance Single submitter
- DNAJB1 p.His99Arg Uncertain significance Single submitter
- DNAJB1 p.Ile289Thr Uncertain significance Single submitter
- DNAJB1 p.Ile48Thr Uncertain significance Single submitter
- DNAJB1 p.Lys73Gln Uncertain significance Single submitter
- DNAJB1 p.Met101Val Uncertain significance Single submitter
- DNAJB1 p.Met293Leu Uncertain significance Single submitter
- DNAJB1 p.Phe45Leu Uncertain significance Single submitter
- DNAJB1 p.Pro135Ser Uncertain significance Single submitter
- DNAJB1 p.Pro298Ala Uncertain significance Single submitter
- DNAJB1 p.Pro305Leu Uncertain significance Single submitter
- DNAJB1 p.Pro305Ser Uncertain significance Single submitter
- DNAJB1 p.Ser186Phe Uncertain significance Single submitter
- DNAJB1 p.Ser330Thr Uncertain significance Single submitter
- DNAJB1 p.Tyr6His Uncertain significance Single submitter
- DNAJB1 p.Val333Ala Uncertain significance Single submitter
- DNAJB1 p.Val54Ala Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- DNAJB1 p.Arg13Cys Uncertain significance Single submitter
- DNAJB1 p.Arg26Leu Uncertain significance Single submitter
- DNAJB1 p.Arg290Ser Uncertain significance Single submitter
- DNAJB1 p.Arg294Trp Uncertain significance Single submitter
- DNAJB1 p.Arg311Cys Uncertain significance Single submitter
- DNAJB1 p.Arg325Gly Uncertain significance Single submitter
- DNAJB1 p.Asn143Asp Uncertain significance Single submitter
- DNAJB1 p.Asn191Lys Uncertain significance Single submitter
- DNAJB1 p.Gln226Arg Uncertain significance Single submitter
- DNAJB1 p.Glu324Gly Uncertain significance Single submitter
- DNAJB1 p.Glu324Lys Uncertain significance Single submitter
- DNAJB1 p.Glu38Asp Uncertain significance Single submitter
- DNAJB1 p.Gly108Ser Uncertain significance Single submitter
- DNAJB1 p.Gly10Asp Uncertain significance Single submitter
- DNAJB1 p.Gly121Arg Uncertain significance Single submitter
- DNAJB1 p.Gly40Ala Uncertain significance Single submitter
- DNAJB1 p.His95Arg Uncertain significance Single submitter
- DNAJB1 p.Ile20Val Uncertain significance Single submitter
- DNAJB1 p.Leu11Met Uncertain significance Single submitter
- DNAJB1 p.Met101Ile Uncertain significance Single submitter
- DNAJB1 p.Met136Val Uncertain significance Single submitter
- DNAJB1 p.Pro232Ala Uncertain significance Single submitter
- DNAJB1 p.Pro274Ser Uncertain significance Single submitter
- DNAJB1 p.Pro298Thr Uncertain significance Single submitter
- DNAJB1 p.Ser132Phe Uncertain significance Single submitter
- DNAJB1 p.Ser261Gly Uncertain significance Single submitter
- DNAJB1 p.Ser75Asn Uncertain significance Single submitter
- DNAJB1 p.Thr114Asn Uncertain significance Single submitter
- DNAJB1 p.Thr142Ile Uncertain significance Single submitter
- DNAJB1 p.Val284Ile Uncertain significance Single submitter
- DNAJB1 p.Val337Phe Uncertain significance Single submitter
All DNAJB1 variants
Likely benign 1
- p.Phe106= Single submitter
Uncertain significance 56
- p.Ala265Val Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg26Leu Single submitter ⚠
- p.Arg290Ser Single submitter ⚠
- p.Arg294Trp Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Arg325Gly Single submitter ⚠
- p.Asn143Asp Single submitter ⚠
- p.Asn143Ser Single submitter ⚠
- p.Asn191Lys Single submitter ⚠
- p.Asn229Ser Single submitter ⚠
- p.Asn245Ser Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Gln226Arg Single submitter ⚠
- p.Gln226His Single submitter ⚠
- p.Glu324Gly Single submitter ⚠
- p.Glu324Lys Single submitter ⚠
- p.Glu38Asp Single submitter ⚠
- p.Gly108Ser Single submitter ⚠
- p.Gly10Asp Single submitter ⚠
- p.Gly121Arg Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly40Ala Single submitter ⚠
- p.His95Arg Single submitter ⚠
- p.His99Arg Single submitter ⚠
- p.Ile20Val Single submitter ⚠
- p.Ile289Thr Single submitter ⚠
- p.Ile48Thr Single submitter ⚠
- p.Leu11Met Single submitter ⚠
- p.Lys73Gln Single submitter ⚠
- p.Met101Ile Single submitter ⚠
- p.Met101Val Single submitter ⚠
- p.Met136Val Single submitter ⚠
- p.Met293Leu Single submitter ⚠
- p.Phe45Leu Single submitter ⚠
- p.Pro135Ser Single submitter ⚠
- p.Pro232Ala Single submitter ⚠
- p.Pro274Ser Single submitter ⚠
- p.Pro298Ala Single submitter ⚠
- p.Pro298Thr Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro305Ser Single submitter ⚠
- p.Ser132Phe Single submitter ⚠
- p.Ser186Phe Single submitter ⚠
- p.Ser261Gly Single submitter ⚠
- p.Ser330Thr Single submitter ⚠
- p.Ser75Asn Single submitter ⚠
- p.Thr114Asn Single submitter ⚠
- p.Thr142Ile Single submitter ⚠
- p.Tyr6His Single submitter ⚠
- p.Val284Ile Single submitter ⚠
- p.Val333Ala Single submitter ⚠
- p.Val337Phe Single submitter ⚠
- p.Val54Ala Single submitter ⚠