DNAJB12 — 59 ClinVar variants
All ClinVar germline DNAJB12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Likely benign · 58 Uncertain significance
Full DNAJB12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB12 p.Ala147Thr Uncertain significance Single submitter
- DNAJB12 p.Ala323Thr Uncertain significance Single submitter
- DNAJB12 p.Ala74Ser Uncertain significance Single submitter
- DNAJB12 p.Ala82Thr Uncertain significance Single submitter
- DNAJB12 p.Ala8Thr Uncertain significance Single submitter
- DNAJB12 p.Arg36Pro Uncertain significance Single submitter
- DNAJB12 p.Arg44Leu Uncertain significance Single submitter
- DNAJB12 p.Asn83Ser Uncertain significance Single submitter
- DNAJB12 p.Asp234Glu Uncertain significance Single submitter
- DNAJB12 p.Asp25Glu Uncertain significance Single submitter
- DNAJB12 p.Glu303Gln Uncertain significance Single submitter
- DNAJB12 p.Glu303Lys Uncertain significance Single submitter
- DNAJB12 p.Glu314Lys Uncertain significance Single submitter
- DNAJB12 p.Gly174Ser Uncertain significance Single submitter
- DNAJB12 p.Gly210Ser Uncertain significance Single submitter
- DNAJB12 p.Gly84Ser Uncertain significance Single submitter
- DNAJB12 p.His282Tyr Uncertain significance Single submitter
- DNAJB12 p.Lys168Arg Uncertain significance Single submitter
- DNAJB12 p.Pro213Arg Uncertain significance Single submitter
- DNAJB12 p.Ser199Phe Uncertain significance Single submitter
- DNAJB12 p.Tyr220Asp Uncertain significance Single submitter
- DNAJB12 p.Val280Leu Uncertain significance Single submitter
- DNAJB12 p.Val280Met Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DNAJB12 p.Ala181Asp Uncertain significance Single submitter
- DNAJB12 p.Ala181Val Uncertain significance Single submitter
- DNAJB12 p.Ala79Val Uncertain significance Single submitter
- DNAJB12 p.Arg224His Uncertain significance Single submitter
- DNAJB12 p.Arg226His Uncertain significance Single submitter
- DNAJB12 p.Arg235Cys Uncertain significance Single submitter
- DNAJB12 p.Arg315Gly Uncertain significance Single submitter
- DNAJB12 p.Arg326Gln Uncertain significance Single submitter
- DNAJB12 p.Asn316Thr Uncertain significance Single submitter
- DNAJB12 p.Asp25Gly Uncertain significance Single submitter
- DNAJB12 p.Glu89Lys Uncertain significance Single submitter
- DNAJB12 p.Glu9Asp Uncertain significance Single submitter
- DNAJB12 p.Gly292Ser Likely benign Single submitter
- DNAJB12 p.Gly307Ala Uncertain significance Single submitter
- DNAJB12 p.Leu16Phe Uncertain significance Single submitter
- DNAJB12 p.Lys5Arg Uncertain significance Single submitter
- DNAJB12 p.Pro270Ala Uncertain significance Single submitter
- DNAJB12 p.Pro63Leu Uncertain significance Single submitter
- DNAJB12 p.Ser122Leu Uncertain significance Single submitter
- DNAJB12 p.Ser221Asn Uncertain significance Single submitter
- DNAJB12 p.Ser221Gly Uncertain significance Single submitter
- DNAJB12 p.Ser81Leu Uncertain significance Single submitter
- DNAJB12 p.Thr156Ile Uncertain significance Single submitter
- DNAJB12 p.Thr312Ile Uncertain significance Single submitter
- DNAJB12 p.Val294Ile Uncertain significance Single submitter
- DNAJB12 p.Val99Ile Uncertain significance Single submitter
All DNAJB12 variants
Likely benign 1
- p.Gly292Ser Single submitter ⚠
Uncertain significance 58
- c.31A>T Single submitter
- c.47C>T Single submitter
- c.74C>A Single submitter
- c.74C>T Single submitter
- c.-2C>T Single submitter
- p.Ala10Thr Single submitter
- p.Ala147Thr Single submitter ⚠
- p.Ala16Pro Single submitter
- p.Ala181Asp Single submitter ⚠
- p.Ala181Val Single submitter ⚠
- p.Ala323Thr Single submitter ⚠
- p.Ala74Ser Single submitter ⚠
- p.Ala79Val Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg315Gly Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg36Pro Single submitter ⚠
- p.Arg44Leu Single submitter ⚠
- p.Asn316Thr Single submitter ⚠
- p.Asn83Ser Single submitter ⚠
- p.Asp234Glu Single submitter ⚠
- p.Asp25Glu Single submitter ⚠
- p.Asp25Gly Single submitter ⚠
- p.Glu303Gln Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Glu314Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Glu9Asp Single submitter ⚠
- p.Gly174Ser Single submitter ⚠
- p.Gly210Ser Single submitter ⚠
- p.Gly307Ala Single submitter ⚠
- p.Gly84Ser Single submitter ⚠
- p.His282Tyr Single submitter ⚠
- p.Leu16Phe Single submitter ⚠
- p.Lys168Arg Single submitter ⚠
- p.Lys5Arg Single submitter ⚠
- p.Pro213Arg Single submitter ⚠
- p.Pro22Ala Single submitter
- p.Pro25Arg Single submitter
- p.Pro270Ala Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser122Leu Single submitter ⚠
- p.Ser199Phe Single submitter ⚠
- p.Ser221Asn Single submitter ⚠
- p.Ser221Gly Single submitter ⚠
- p.Ser26Phe Single submitter
- p.Ser81Leu Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Tyr220Asp Single submitter ⚠
- p.Val280Leu Single submitter ⚠
- p.Val280Met Single submitter ⚠
- p.Val294Ile Single submitter ⚠
- p.Val99Ile Single submitter ⚠