DNAJB14 — 37 ClinVar variants
All ClinVar germline DNAJB14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
37 Uncertain significance
Full DNAJB14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB14 p.Arg350His Uncertain significance Single submitter
- DNAJB14 p.Arg355Gln Uncertain significance Single submitter
- DNAJB14 p.Arg64Gln Uncertain significance Single submitter
- DNAJB14 p.Asn327Asp Uncertain significance Single submitter
- DNAJB14 p.Asp71Asn Uncertain significance Single submitter
- DNAJB14 p.Gln314His Uncertain significance Single submitter
- DNAJB14 p.Gln72Leu Uncertain significance Single submitter
- DNAJB14 p.Glu17Asp Uncertain significance Single submitter
- DNAJB14 p.Glu240Gln Uncertain significance Single submitter
- DNAJB14 p.Gly243Arg Uncertain significance Single submitter
- DNAJB14 p.Gly243Glu Uncertain significance Single submitter
- DNAJB14 p.Ile260Val Uncertain significance Single submitter
- DNAJB14 p.Ile328Ser Uncertain significance Single submitter
- DNAJB14 p.Leu159Val Uncertain significance Single submitter
- DNAJB14 p.Lys134Met Uncertain significance Single submitter
- DNAJB14 p.Pro279Ala Uncertain significance Single submitter
- DNAJB14 p.Pro66Ser Uncertain significance Single submitter
- DNAJB14 p.Ser81Gly Uncertain significance Single submitter
- DNAJB14 p.Thr116Ala Uncertain significance Single submitter
- DNAJB14 p.Val158Ala Uncertain significance Single submitter
- DNAJB14 p.Val262Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DNAJB14 p.Ala43Gly Uncertain significance Single submitter
- DNAJB14 p.Arg350Cys Uncertain significance Single submitter
- DNAJB14 p.Arg371Gln Uncertain significance Single submitter
- DNAJB14 p.Arg64Leu Uncertain significance Single submitter
- DNAJB14 p.Asp352Gly Uncertain significance Single submitter
- DNAJB14 p.Asp98Asn Uncertain significance Single submitter
- DNAJB14 p.Gln32Arg Uncertain significance Single submitter
- DNAJB14 p.Glu9Ala Uncertain significance Single submitter
- DNAJB14 p.Pro273Leu Uncertain significance Single submitter
- DNAJB14 p.Ser67Leu Uncertain significance Single submitter
- DNAJB14 p.Ser69Ile Uncertain significance Single submitter
- DNAJB14 p.Thr116Met Uncertain significance Single submitter
- DNAJB14 p.Tyr278His Uncertain significance Single submitter
- DNAJB14 p.Tyr324Phe Uncertain significance Single submitter
- DNAJB14 p.Tyr344His Uncertain significance Single submitter
- DNAJB14 p.Val100Ile Uncertain significance Single submitter
All DNAJB14 variants
Uncertain significance 37
- p.Ala43Gly Single submitter ⚠
- p.Arg350Cys Single submitter ⚠
- p.Arg350His Single submitter ⚠
- p.Arg355Gln Single submitter ⚠
- p.Arg371Gln Single submitter ⚠
- p.Arg64Gln Single submitter ⚠
- p.Arg64Leu Single submitter ⚠
- p.Asn327Asp Single submitter ⚠
- p.Asp352Gly Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Asp98Asn Single submitter ⚠
- p.Gln314His Single submitter ⚠
- p.Gln32Arg Single submitter ⚠
- p.Gln72Leu Single submitter ⚠
- p.Glu17Asp Single submitter ⚠
- p.Glu240Gln Single submitter ⚠
- p.Glu9Ala Single submitter ⚠
- p.Gly243Arg Single submitter ⚠
- p.Gly243Glu Single submitter ⚠
- p.Ile260Val Single submitter ⚠
- p.Ile328Ser Single submitter ⚠
- p.Leu159Val Single submitter ⚠
- p.Lys134Met Single submitter ⚠
- p.Pro273Leu Single submitter ⚠
- p.Pro279Ala Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Ser67Leu Single submitter ⚠
- p.Ser69Ile Single submitter ⚠
- p.Ser81Gly Single submitter ⚠
- p.Thr116Ala Single submitter ⚠
- p.Thr116Met Single submitter ⚠
- p.Tyr278His Single submitter ⚠
- p.Tyr324Phe Single submitter ⚠
- p.Tyr344His Single submitter ⚠
- p.Val100Ile Single submitter ⚠
- p.Val158Ala Single submitter ⚠
- p.Val262Leu Single submitter ⚠