DNAJB7 — 65 ClinVar variants
All ClinVar germline DNAJB7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
4 Likely benign · 61 Uncertain significance
Full DNAJB7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB7 p.Ala27Thr Uncertain significance Single submitter
- DNAJB7 p.Arg122Gly Uncertain significance Single submitter
- DNAJB7 p.Arg12Lys Uncertain significance Single submitter
- DNAJB7 p.Arg277Ser Uncertain significance Single submitter
- DNAJB7 p.Arg307Lys Uncertain significance Single submitter
- DNAJB7 p.Asn200Lys Uncertain significance Single submitter
- DNAJB7 p.Asp182His Uncertain significance Single submitter
- DNAJB7 p.Asp59His Uncertain significance Single submitter
- DNAJB7 p.Asp66Gly Uncertain significance Single submitter
- DNAJB7 p.Asp82Glu Uncertain significance Single submitter
- DNAJB7 p.Cys309Ser Uncertain significance Single submitter
- DNAJB7 p.Cys84Arg Uncertain significance Single submitter
- DNAJB7 p.Glu148Gln Uncertain significance Single submitter
- DNAJB7 p.Glu166Lys Uncertain significance Single submitter
- DNAJB7 p.Glu17Asp Uncertain significance Single submitter
- DNAJB7 p.Glu230Lys Uncertain significance Single submitter
- DNAJB7 p.Glu231Lys Uncertain significance Single submitter
- DNAJB7 p.Glu85Gly Uncertain significance Single submitter
- DNAJB7 p.Glu99Asp Uncertain significance Single submitter
- DNAJB7 p.Gly164Arg Uncertain significance Single submitter
- DNAJB7 p.Gly269Asp Uncertain significance Single submitter
- DNAJB7 p.Gly290Asp Uncertain significance Single submitter
- DNAJB7 p.Ile185Leu Uncertain significance Single submitter
- DNAJB7 p.Ile185Thr Uncertain significance Single submitter
- DNAJB7 p.Ile270Thr Uncertain significance Single submitter
- DNAJB7 p.Ile281Val Uncertain significance Single submitter
- DNAJB7 p.Leu163Ser Uncertain significance Single submitter
- DNAJB7 p.Lys20Asn Uncertain significance Single submitter
- DNAJB7 p.Lys293Glu Uncertain significance Single submitter
- DNAJB7 p.Lys92Thr Uncertain significance Single submitter
- DNAJB7 p.Met181Thr Uncertain significance Single submitter
- DNAJB7 p.Phe137Cys Uncertain significance Single submitter
- DNAJB7 p.Phe221Val Uncertain significance Single submitter
- DNAJB7 p.Phe80Ser Uncertain significance Single submitter
- DNAJB7 p.Pro123Leu Uncertain significance Single submitter
- DNAJB7 p.Pro280Leu Uncertain significance Single submitter
- DNAJB7 p.Ser207Thr Uncertain significance Single submitter
- DNAJB7 p.Ser283Leu Uncertain significance Single submitter
- DNAJB7 p.Thr189Ser Uncertain significance Single submitter
- DNAJB7 p.Tyr13Cys Uncertain significance Single submitter
- DNAJB7 p.Tyr260Asn Uncertain significance Single submitter
- DNAJB7 p.Tyr260His Uncertain significance Single submitter
- DNAJB7 p.Val7Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- DNAJB7 p.Ala50Gly Uncertain significance Single submitter
- DNAJB7 p.Arg297His Likely benign Single submitter
- DNAJB7 p.Arg62Gln Uncertain significance Single submitter
- DNAJB7 p.Asn38Lys Uncertain significance Single submitter
- DNAJB7 p.Asp215Tyr Uncertain significance Single submitter
- DNAJB7 p.Asp95Tyr Uncertain significance Single submitter
- DNAJB7 p.Glu103Ala Uncertain significance Single submitter
- DNAJB7 p.Glu41Asp Uncertain significance Single submitter
- DNAJB7 p.Glu54Lys Uncertain significance Single submitter
- DNAJB7 p.Glu71Gly Uncertain significance Single submitter
- DNAJB7 p.Gly196Ser Uncertain significance Single submitter
- DNAJB7 p.Gly87Asp Uncertain significance Single submitter
- DNAJB7 p.Gly9Ala Uncertain significance Single submitter
- DNAJB7 p.Leu8Ile Uncertain significance Single submitter
- DNAJB7 p.Lys303Met Uncertain significance Single submitter
- DNAJB7 p.Pro32Leu Uncertain significance Single submitter
- DNAJB7 p.Ser186Pro Uncertain significance Single submitter
- DNAJB7 p.Tyr5Cys Uncertain significance Single submitter
- DNAJB7 p.Val2Glu Uncertain significance Single submitter
All DNAJB7 variants
Likely benign 4
- p.Arg122His Single submitter
- p.Arg122Ser Single submitter
- p.Arg297His Single submitter ⚠
- p.Ile146Val Single submitter
Uncertain significance 61
- p.Ala27Thr Single submitter ⚠
- p.Ala50Gly Single submitter ⚠
- p.Arg122Gly Single submitter ⚠
- p.Arg12Lys Single submitter ⚠
- p.Arg277Ser Single submitter ⚠
- p.Arg307Lys Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Asn200Lys Single submitter ⚠
- p.Asn38Lys Single submitter ⚠
- p.Asp182His Single submitter ⚠
- p.Asp215Tyr Single submitter ⚠
- p.Asp59His Single submitter ⚠
- p.Asp66Gly Single submitter ⚠
- p.Asp82Glu Single submitter ⚠
- p.Asp95Tyr Single submitter ⚠
- p.Cys309Ser Single submitter ⚠
- p.Cys84Arg Single submitter ⚠
- p.Glu103Ala Single submitter ⚠
- p.Glu148Gln Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu17Asp Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu231Lys Single submitter ⚠
- p.Glu41Asp Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Glu71Gly Single submitter ⚠
- p.Glu85Gly Single submitter ⚠
- p.Glu99Asp Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly196Ser Single submitter ⚠
- p.Gly269Asp Single submitter ⚠
- p.Gly290Asp Single submitter ⚠
- p.Gly87Asp Single submitter ⚠
- p.Gly9Ala Single submitter ⚠
- p.Ile185Leu Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile270Thr Single submitter ⚠
- p.Ile281Val Single submitter ⚠
- p.Leu163Ser Single submitter ⚠
- p.Leu8Ile Single submitter ⚠
- p.Lys20Asn Single submitter ⚠
- p.Lys293Glu Single submitter ⚠
- p.Lys303Met Single submitter ⚠
- p.Lys92Thr Single submitter ⚠
- p.Met181Thr Single submitter ⚠
- p.Phe137Cys Single submitter ⚠
- p.Phe221Val Single submitter ⚠
- p.Phe80Ser Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro280Leu Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Ser186Pro Single submitter ⚠
- p.Ser207Thr Single submitter ⚠
- p.Ser283Leu Single submitter ⚠
- p.Thr189Ser Single submitter ⚠
- p.Tyr13Cys Single submitter ⚠
- p.Tyr260Asn Single submitter ⚠
- p.Tyr260His Single submitter ⚠
- p.Tyr5Cys Single submitter ⚠
- p.Val2Glu Single submitter ⚠
- p.Val7Ile Single submitter ⚠