DNAJB8 — 51 ClinVar variants
All ClinVar germline DNAJB8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
3 Benign · 2 Likely benign · 46 Uncertain significance
Full DNAJB8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB8 p.Ala143Asp Uncertain significance Single submitter
- DNAJB8 p.Ala143Gly Uncertain significance Single submitter
- DNAJB8 p.Ala68Thr Uncertain significance Single submitter
- DNAJB8 p.Arg131Ser Uncertain significance Single submitter
- DNAJB8 p.Arg62His Uncertain significance Single submitter
- DNAJB8 p.Arg67His Uncertain significance Single submitter
- DNAJB8 p.Arg74Gln Uncertain significance Single submitter
- DNAJB8 p.Asn120His Uncertain significance Single submitter
- DNAJB8 p.Asp88Asn Uncertain significance Single submitter
- DNAJB8 p.Asp88His Uncertain significance Single submitter
- DNAJB8 p.Gly127Ser Uncertain significance Single submitter
- DNAJB8 p.Met145Val Uncertain significance Single submitter
- DNAJB8 p.Ser13Gly Uncertain significance Single submitter
- DNAJB8 p.Trp115Arg Uncertain significance Single submitter
- DNAJB8 p.Trp228Cys Uncertain significance Single submitter
- DNAJB8 p.Val10Met Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- DNAJB8 p.Ala147Val Uncertain significance Single submitter
- DNAJB8 p.Arg101Gln Benign Single submitter
- DNAJB8 p.Arg123Cys Likely benign Single submitter
- DNAJB8 p.Arg206His Uncertain significance Single submitter
- DNAJB8 p.Arg24His Uncertain significance Single submitter
- DNAJB8 p.Arg29His Uncertain significance Single submitter
- DNAJB8 p.Arg67Gly Uncertain significance Single submitter
- DNAJB8 p.Arg67Leu Uncertain significance Single submitter
- DNAJB8 p.Arg94Cys Uncertain significance Single submitter
- DNAJB8 p.Asn38His Uncertain significance Single submitter
- DNAJB8 p.Asn95Lys Uncertain significance Single submitter
- DNAJB8 p.Asp108Asn Uncertain significance Single submitter
- DNAJB8 p.Asp212Asn Uncertain significance Single submitter
- DNAJB8 p.Asp58Asn Uncertain significance Single submitter
- DNAJB8 p.Glu6Lys Uncertain significance Single submitter
- DNAJB8 p.Gly170Arg Uncertain significance Single submitter
- DNAJB8 p.Gly191Asp Uncertain significance Single submitter
- DNAJB8 p.Gly203Arg Uncertain significance Single submitter
- DNAJB8 p.Gly213Arg Uncertain significance Single submitter
- DNAJB8 p.Gly222Arg Uncertain significance Single submitter
- DNAJB8 p.Gly222Ser Uncertain significance Single submitter
- DNAJB8 p.Leu48Pro Uncertain significance Single submitter
- DNAJB8 p.Lys39Met Uncertain significance Single submitter
- DNAJB8 p.Lys39Thr Uncertain significance Single submitter
- DNAJB8 p.Phe164Cys Uncertain significance Single submitter
- DNAJB8 p.Phe179Tyr Uncertain significance Single submitter
- DNAJB8 p.Pro16Leu Uncertain significance Single submitter
- DNAJB8 p.Ser59Tyr Uncertain significance Single submitter
- DNAJB8 p.Thr162Asn Uncertain significance Single submitter
- DNAJB8 p.Thr196Ala Uncertain significance Single submitter
- DNAJB8 p.Thr81Met Uncertain significance Single submitter
- DNAJB8 p.Val220Met Uncertain significance Single submitter
All DNAJB8 variants
Benign 3
- p.Glu6= Multiple submitters
- p.Met153Leu Multiple submitters
- p.Arg101Gln Single submitter ⚠
Likely benign 2
- p.Arg123Cys Single submitter ⚠
- p.Trp228Arg Single submitter
Uncertain significance 46
- p.Ala143Asp Single submitter ⚠
- p.Ala143Gly Single submitter ⚠
- p.Ala147Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg131Ser Single submitter ⚠
- p.Arg206His Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg29His Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg67Gly Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Arg67Leu Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Asn120His Single submitter ⚠
- p.Asn38His Single submitter ⚠
- p.Asn95Lys Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp212Asn Single submitter ⚠
- p.Asp58Asn Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Asp88His Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly191Asp Single submitter ⚠
- p.Gly203Arg Single submitter ⚠
- p.Gly213Arg Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.Gly222Ser Single submitter ⚠
- p.Leu48Pro Single submitter ⚠
- p.Lys39Met Single submitter ⚠
- p.Lys39Thr Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Phe164Cys Single submitter ⚠
- p.Phe179Tyr Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Ser13Gly Single submitter ⚠
- p.Ser59Tyr Single submitter ⚠
- p.Thr162Asn Single submitter ⚠
- p.Thr196Ala Single submitter ⚠
- p.Thr81Met Single submitter ⚠
- p.Trp115Arg Single submitter ⚠
- p.Trp228Cys Single submitter ⚠
- p.Val10Met Single submitter ⚠
- p.Val220Met Single submitter ⚠