DNAJB9 — 40 ClinVar variants
All ClinVar germline DNAJB9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Benign · 1 Likely benign · 38 Uncertain significance
Full DNAJB9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJB9 p.Ala63Val Uncertain significance Single submitter
- DNAJB9 p.Arg101Gly Uncertain significance Single submitter
- DNAJB9 p.Asn81Asp Uncertain significance Single submitter
- DNAJB9 p.Asn81Lys Uncertain significance Single submitter
- DNAJB9 p.Gln157Arg Uncertain significance Single submitter
- DNAJB9 p.Gln223Arg Uncertain significance Single submitter
- DNAJB9 p.Gln41His Uncertain significance Single submitter
- DNAJB9 p.Gly147Arg Uncertain significance Single submitter
- DNAJB9 p.Gly211Arg Uncertain significance Single submitter
- DNAJB9 p.Gly222Val Uncertain significance Single submitter
- DNAJB9 p.Ile9Val Uncertain significance Single submitter
- DNAJB9 p.Leu22Val Uncertain significance Single submitter
- DNAJB9 p.Leu49Phe Uncertain significance Single submitter
- DNAJB9 p.Leu77Phe Uncertain significance Single submitter
- DNAJB9 p.Lys134Glu Uncertain significance Single submitter
- DNAJB9 p.Met213Thr Uncertain significance Single submitter
- DNAJB9 p.Phe113Ser Uncertain significance Single submitter
- DNAJB9 p.Phe122Leu Uncertain significance Single submitter
- DNAJB9 p.Phe179Leu Uncertain significance Single submitter
- DNAJB9 p.Phe8Leu Uncertain significance Single submitter
- DNAJB9 p.Ser200Gly Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- DNAJB9 p.Ala45Thr Uncertain significance Single submitter
- DNAJB9 p.Ala80Asp Uncertain significance Single submitter
- DNAJB9 p.Arg144Cys Uncertain significance Single submitter
- DNAJB9 p.Arg82Gly Uncertain significance Single submitter
- DNAJB9 p.Gln142Pro Uncertain significance Single submitter
- DNAJB9 p.Glu138Val Uncertain significance Single submitter
- DNAJB9 p.Ile7Ser Uncertain significance Single submitter
- DNAJB9 p.Lys25Glu Uncertain significance Single submitter
- DNAJB9 p.Lys43Arg Uncertain significance Single submitter
- DNAJB9 p.Met173Arg Uncertain significance Single submitter
- DNAJB9 p.Met176Ile Uncertain significance Single submitter
- DNAJB9 p.Phe196Leu Uncertain significance Single submitter
- DNAJB9 p.Ser78Leu Uncertain significance Single submitter
- DNAJB9 p.Ser96Arg Uncertain significance Single submitter
- DNAJB9 p.Thr88Arg Uncertain significance Single submitter
- DNAJB9 p.Thr88Ile Uncertain significance Single submitter
- DNAJB9 p.Tyr217His Uncertain significance Single submitter
All DNAJB9 variants
Benign 1
- p.Arg136His Multiple submitters
Likely benign 1
- p.Ile7Val Single submitter
Uncertain significance 38
- p.Ala45Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Ala80Asp Single submitter ⚠
- p.Arg101Gly Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg82Gly Single submitter ⚠
- p.Asn81Asp Single submitter ⚠
- p.Asn81Lys Single submitter ⚠
- p.Gln142Pro Single submitter ⚠
- p.Gln157Arg Single submitter ⚠
- p.Gln223Arg Single submitter ⚠
- p.Gln41His Single submitter ⚠
- p.Glu138Val Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Gly211Arg Single submitter ⚠
- p.Gly222Val Single submitter ⚠
- p.Ile7Ser Single submitter ⚠
- p.Ile9Val Single submitter ⚠
- p.Leu22Val Single submitter ⚠
- p.Leu49Phe Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Lys134Glu Single submitter ⚠
- p.Lys25Glu Single submitter ⚠
- p.Lys43Arg Single submitter ⚠
- p.Met173Arg Single submitter ⚠
- p.Met176Ile Single submitter ⚠
- p.Met213Thr Single submitter ⚠
- p.Phe113Ser Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Phe179Leu Single submitter ⚠
- p.Phe196Leu Single submitter ⚠
- p.Phe8Leu Single submitter ⚠
- p.Ser200Gly Single submitter ⚠
- p.Ser78Leu Single submitter ⚠
- p.Ser96Arg Single submitter ⚠
- p.Thr88Arg Single submitter ⚠
- p.Thr88Ile Single submitter ⚠
- p.Tyr217His Single submitter ⚠