DNAJC10 — 102 ClinVar variants

All ClinVar germline DNAJC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 101 flagged for review →

1 Likely benign · 101 Uncertain significance

Full DNAJC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 101

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 57

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 44

The independent predictors disagree with each other — read with care.

All DNAJC10 variants

Likely benign 1

p.Val671Ala Single submitter

Uncertain significance 101

p.Ala697Pro Multiple submitters ⚠
p.Ala730Thr Single submitter ⚠
p.Ala772Ser Single submitter ⚠
p.Arg119Cys Single submitter ⚠
p.Arg119His Single submitter ⚠
p.Arg16Met Single submitter ⚠
p.Arg208Gln Single submitter ⚠
p.Arg361His Single submitter ⚠
p.Arg366Trp Single submitter ⚠
p.Arg400Gly Single submitter ⚠
p.Arg492Gly Single submitter ⚠
p.Arg715Met Single submitter ⚠
p.Asn247Lys Single submitter ⚠
p.Asn299Lys Single submitter ⚠
p.Asn322Ser Single submitter ⚠
p.Asn356Tyr Single submitter ⚠
p.Asn452Tyr Single submitter ⚠
p.Asn466Ser Single submitter ⚠
p.Asn689Ser Single submitter ⚠
p.Asn69His Single submitter ⚠
p.Asp189Glu Single submitter ⚠
p.Asp269Gly Single submitter ⚠
p.Asp284Val Single submitter ⚠
p.Asp552Asn Single submitter ⚠
p.Asp656Glu Single submitter ⚠
p.Asp791Asn Single submitter ⚠
p.Asp91His Single submitter ⚠
p.Asp91Tyr Single submitter ⚠
p.Cys186Ser Single submitter ⚠
p.Cys20Arg Single submitter ⚠
p.Cys301Phe Single submitter ⚠
p.Cys480Arg Single submitter ⚠
p.Cys700Tyr Single submitter ⚠
p.Gln34His Single submitter ⚠
p.Gln762Arg Single submitter ⚠
p.Glu536Gly Single submitter ⚠
p.Glu597Gln Single submitter ⚠
p.Glu682Asp Single submitter ⚠
p.Glu752Lys Single submitter ⚠
p.Glu780Gly Single submitter ⚠
p.Gly103Arg Single submitter ⚠
p.Gly499Val Single submitter ⚠
p.Gly739Glu Single submitter ⚠
p.Gly75Arg Single submitter ⚠
p.His232Arg Single submitter ⚠
p.His364Tyr Single submitter ⚠
p.His435Arg Single submitter ⚠
p.His435Asn Single submitter ⚠
p.His540Arg Single submitter ⚠
p.His620Asn Single submitter ⚠
p.Ile18Leu Single submitter ⚠
p.Ile18Val Single submitter ⚠
p.Ile206Val Single submitter ⚠
p.Ile771Met Single submitter ⚠
p.Leu204His Single submitter ⚠
p.Leu391Phe Single submitter ⚠
p.Leu391Val Single submitter ⚠
p.Leu444Phe Single submitter ⚠
p.Leu713Ser Single submitter ⚠
p.Leu782Pro Single submitter ⚠
p.Leu782Val Single submitter ⚠
p.Lys392Glu Single submitter ⚠
p.Met554Thr Single submitter ⚠
p.Phe139Tyr Single submitter ⚠
p.Phe150Val Single submitter ⚠
p.Phe263Leu Single submitter ⚠
p.Phe36Leu Single submitter ⚠
p.Phe529Cys Single submitter ⚠
p.Phe529Val Single submitter ⚠
p.Phe636Cys Single submitter ⚠
p.Phe750Ser Single submitter ⚠
p.Phe758Val Single submitter ⚠
p.Pro418Ser Single submitter ⚠
p.Pro524Ser Single submitter ⚠
p.Pro669Ser Single submitter ⚠
p.Pro677Leu Single submitter ⚠
p.Pro68Leu Single submitter ⚠
p.Pro698Leu Single submitter ⚠
p.Ser200Cys Single submitter ⚠
p.Ser450Thr Single submitter ⚠
p.Ser560Phe Single submitter ⚠
p.Thr236Ala Single submitter ⚠
p.Thr272Ala Single submitter ⚠
p.Thr457Met Single submitter ⚠
p.Thr509Ile Single submitter ⚠
p.Thr564Ile Single submitter ⚠
p.Thr676Ile Single submitter ⚠
p.Thr781Ala Single submitter ⚠
p.Trp259Arg Single submitter ⚠
p.Tyr584Cys Single submitter ⚠
p.Tyr619Cys Single submitter ⚠
p.Tyr650Cys Single submitter ⚠
p.Tyr696Cys Single submitter ⚠
p.Val143Ile Single submitter ⚠
p.Val184Ile Single submitter ⚠
p.Val451Met Single submitter ⚠
p.Val570Ile Single submitter ⚠
p.Val611Gly Single submitter ⚠
p.Val692Ala Single submitter ⚠
p.Val746Phe Single submitter ⚠
p.Val86Ile Single submitter ⚠