DNAJC14 — 93 ClinVar variants
All ClinVar germline DNAJC14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
2 Likely benign · 91 Uncertain significance
Full DNAJC14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC14 p.Ala128Val Uncertain significance Single submitter
- DNAJC14 p.Ala161Thr Uncertain significance Single submitter
- DNAJC14 p.Ala20Gly Uncertain significance Single submitter
- DNAJC14 p.Ala20Val Uncertain significance Single submitter
- DNAJC14 p.Ala250Glu Uncertain significance Single submitter
- DNAJC14 p.Ala275Ser Uncertain significance Single submitter
- DNAJC14 p.Ala302Thr Uncertain significance Single submitter
- DNAJC14 p.Ala417Asp Uncertain significance Single submitter
- DNAJC14 p.Ala480Thr Uncertain significance Single submitter
- DNAJC14 p.Ala688Gly Uncertain significance Single submitter
- DNAJC14 p.Arg200His Uncertain significance Single submitter
- DNAJC14 p.Arg212His Uncertain significance Single submitter
- DNAJC14 p.Arg212Leu Uncertain significance Single submitter
- DNAJC14 p.Arg212Ser Uncertain significance Single submitter
- DNAJC14 p.Arg355Trp Uncertain significance Single submitter
- DNAJC14 p.Arg389Trp Uncertain significance Single submitter
- DNAJC14 p.Arg420Leu Uncertain significance Single submitter
- DNAJC14 p.Arg649Gln Uncertain significance Single submitter
- DNAJC14 p.Arg698Lys Uncertain significance Single submitter
- DNAJC14 p.Asn660Ser Uncertain significance Single submitter
- DNAJC14 p.Asn680Lys Uncertain significance Single submitter
- DNAJC14 p.Asp182Tyr Uncertain significance Single submitter
- DNAJC14 p.Asp354Glu Uncertain significance Single submitter
- DNAJC14 p.Asp642Tyr Uncertain significance Single submitter
- DNAJC14 p.Asp91Gly Uncertain significance Single submitter
- DNAJC14 p.Gln197Glu Uncertain significance Single submitter
- DNAJC14 p.Gln92Glu Uncertain significance Single submitter
- DNAJC14 p.Gln92Leu Uncertain significance Single submitter
- DNAJC14 p.Glu174Asp Uncertain significance Single submitter
- DNAJC14 p.Glu55Asp Uncertain significance Single submitter
- DNAJC14 p.Glu569Lys Uncertain significance Single submitter
- DNAJC14 p.Gly328Val Uncertain significance Single submitter
- DNAJC14 p.Gly351Arg Uncertain significance Single submitter
- DNAJC14 p.Gly353Val Uncertain significance Single submitter
- DNAJC14 p.Gly44Arg Uncertain significance Single submitter
- DNAJC14 p.His16Tyr Uncertain significance Single submitter
- DNAJC14 p.Ile137Met Uncertain significance Single submitter
- DNAJC14 p.Ile393Leu Uncertain significance Single submitter
- DNAJC14 p.Leu107His Uncertain significance Single submitter
- DNAJC14 p.Leu167Val Uncertain significance Single submitter
- DNAJC14 p.Leu244Val Uncertain significance Single submitter
- DNAJC14 p.Leu319Met Uncertain significance Single submitter
- DNAJC14 p.Leu326Val Uncertain significance Single submitter
- DNAJC14 p.Leu344Phe Uncertain significance Single submitter
- DNAJC14 p.Leu53His Uncertain significance Single submitter
- DNAJC14 p.Met579Thr Uncertain significance Single submitter
- DNAJC14 p.Met658Ile Uncertain significance Single submitter
- DNAJC14 p.Phe320Leu Uncertain significance Single submitter
- DNAJC14 p.Pro31Ala Uncertain significance Single submitter
- DNAJC14 p.Pro386Arg Uncertain significance Single submitter
- DNAJC14 p.Ser281Thr Uncertain significance Single submitter
- DNAJC14 p.Ser418Arg Uncertain significance Single submitter
- DNAJC14 p.Ser42Leu Uncertain significance Single submitter
- DNAJC14 p.Ser623Thr Uncertain significance Single submitter
- DNAJC14 p.Thr207Ser Uncertain significance Single submitter
- DNAJC14 p.Thr24Ala Uncertain significance Single submitter
- DNAJC14 p.Trp70Arg Uncertain significance Single submitter
- DNAJC14 p.Tyr274Cys Uncertain significance Single submitter
- DNAJC14 p.Val29Met Uncertain significance Single submitter
- DNAJC14 p.Val304Leu Uncertain significance Single submitter
- DNAJC14 p.Val391Leu Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- DNAJC14 p.Ala634Val Uncertain significance Single submitter
- DNAJC14 p.Arg208Trp Uncertain significance Single submitter
- DNAJC14 p.Arg222Gln Uncertain significance Single submitter
- DNAJC14 p.Arg347Trp Uncertain significance Single submitter
- DNAJC14 p.Arg376Cys Uncertain significance Single submitter
- DNAJC14 p.Arg376Pro Uncertain significance Single submitter
- DNAJC14 p.Arg420His Uncertain significance Single submitter
- DNAJC14 p.Arg546Lys Uncertain significance Single submitter
- DNAJC14 p.Arg551Gln Uncertain significance Single submitter
- DNAJC14 p.Arg649Trp Uncertain significance Single submitter
- DNAJC14 p.Arg692Trp Uncertain significance Single submitter
- DNAJC14 p.Asp637Tyr Uncertain significance Single submitter
- DNAJC14 p.Gln652Glu Uncertain significance Single submitter
- DNAJC14 p.Glu168Gly Uncertain significance Single submitter
- DNAJC14 p.Glu512Asp Uncertain significance Single submitter
- DNAJC14 p.Gly449Ala Uncertain significance Single submitter
- DNAJC14 p.Gly607Ala Uncertain significance Single submitter
- DNAJC14 p.Leu258Gln Uncertain significance Single submitter
- DNAJC14 p.Leu380Met Uncertain significance Single submitter
- DNAJC14 p.Met535Ile Uncertain significance Single submitter
- DNAJC14 p.Pro636Leu Uncertain significance Single submitter
- DNAJC14 p.Pro654His Uncertain significance Single submitter
- DNAJC14 p.Pro690Ser Uncertain significance Single submitter
- DNAJC14 p.Ser149Tyr Uncertain significance Single submitter
- DNAJC14 p.Ser159Phe Uncertain significance Single submitter
- DNAJC14 p.Ser194Cys Uncertain significance Single submitter
- DNAJC14 p.Ser367Tyr Uncertain significance Single submitter
- DNAJC14 p.Thr363Ile Uncertain significance Single submitter
- DNAJC14 p.Thr54Ile Uncertain significance Single submitter
- DNAJC14 p.Thr95Met Uncertain significance Single submitter
All DNAJC14 variants
Likely benign 2
- p.Arg389Gln Multiple submitters
- p.Gly211Glu No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 91
- p.Ala128Val Single submitter ⚠
- p.Ala161Thr Single submitter ⚠
- p.Ala20Gly Single submitter ⚠
- p.Ala20Val Single submitter ⚠
- p.Ala250Glu Single submitter ⚠
- p.Ala275Ser Single submitter ⚠
- p.Ala302Thr Single submitter ⚠
- p.Ala417Asp Single submitter ⚠
- p.Ala480Thr Single submitter ⚠
- p.Ala634Val Single submitter ⚠
- p.Ala688Gly Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg208Trp Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg212Leu Single submitter ⚠
- p.Arg212Ser Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg355Trp Single submitter ⚠
- p.Arg376Cys Single submitter ⚠
- p.Arg376Pro Single submitter ⚠
- p.Arg389Trp Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg420Leu Single submitter ⚠
- p.Arg546Lys Single submitter ⚠
- p.Arg551Gln Single submitter ⚠
- p.Arg649Gln Single submitter ⚠
- p.Arg649Trp Single submitter ⚠
- p.Arg692Trp Single submitter ⚠
- p.Arg698Lys Single submitter ⚠
- p.Asn660Ser Single submitter ⚠
- p.Asn680Lys Single submitter ⚠
- p.Asp182Tyr Single submitter ⚠
- p.Asp354Glu Single submitter ⚠
- p.Asp637Tyr Single submitter ⚠
- p.Asp642Tyr Single submitter ⚠
- p.Asp91Gly Single submitter ⚠
- p.Gln197Glu Single submitter ⚠
- p.Gln652Glu Single submitter ⚠
- p.Gln92Glu Single submitter ⚠
- p.Gln92Leu Single submitter ⚠
- p.Glu168Gly Single submitter ⚠
- p.Glu174Asp Single submitter ⚠
- p.Glu512Asp Single submitter ⚠
- p.Glu55Asp Single submitter ⚠
- p.Glu569Lys Single submitter ⚠
- p.Gly328Val Single submitter ⚠
- p.Gly351Arg Single submitter ⚠
- p.Gly353Val Single submitter ⚠
- p.Gly449Ala Single submitter ⚠
- p.Gly44Arg Single submitter ⚠
- p.Gly607Ala Single submitter ⚠
- p.His16Tyr Single submitter ⚠
- p.Ile137Met Single submitter ⚠
- p.Ile393Leu Single submitter ⚠
- p.Leu107His Single submitter ⚠
- p.Leu167Val Single submitter ⚠
- p.Leu244Val Single submitter ⚠
- p.Leu258Gln Single submitter ⚠
- p.Leu319Met Single submitter ⚠
- p.Leu326Val Single submitter ⚠
- p.Leu344Phe Single submitter ⚠
- p.Leu380Met Single submitter ⚠
- p.Leu53His Single submitter ⚠
- p.Met535Ile Single submitter ⚠
- p.Met579Thr Single submitter ⚠
- p.Met658Ile Single submitter ⚠
- p.Phe320Leu Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Pro386Arg Single submitter ⚠
- p.Pro636Leu Single submitter ⚠
- p.Pro654His Single submitter ⚠
- p.Pro690Ser Single submitter ⚠
- p.Ser149Tyr Single submitter ⚠
- p.Ser159Phe Single submitter ⚠
- p.Ser194Cys Single submitter ⚠
- p.Ser281Thr Single submitter ⚠
- p.Ser367Tyr Single submitter ⚠
- p.Ser418Arg Single submitter ⚠
- p.Ser42Leu Single submitter ⚠
- p.Ser623Thr Single submitter ⚠
- p.Thr207Ser Single submitter ⚠
- p.Thr24Ala Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Thr54Ile Single submitter ⚠
- p.Thr95Met Single submitter ⚠
- p.Trp70Arg Single submitter ⚠
- p.Tyr274Cys Single submitter ⚠
- p.Val29Met Single submitter ⚠
- p.Val304Leu Single submitter ⚠
- p.Val391Leu Single submitter ⚠