DNAJC16 — 118 ClinVar variants
All ClinVar germline DNAJC16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
11 Likely benign · 107 Uncertain significance
Full DNAJC16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC16 p.Ala53Ser Uncertain significance Single submitter
- DNAJC16 p.Ala53Thr Uncertain significance Single submitter
- DNAJC16 p.Ala95Thr Uncertain significance Single submitter
- DNAJC16 p.Arg111His Uncertain significance Single submitter
- DNAJC16 p.Arg113His Uncertain significance Single submitter
- DNAJC16 p.Arg134Gln Uncertain significance Single submitter
- DNAJC16 p.Arg204Lys Uncertain significance Single submitter
- DNAJC16 p.Arg343Gln Uncertain significance Single submitter
- DNAJC16 p.Arg364Ser Uncertain significance Single submitter
- DNAJC16 p.Arg379Gln Uncertain significance Single submitter
- DNAJC16 p.Arg382Gln Uncertain significance Single submitter
- DNAJC16 p.Arg486His Uncertain significance Single submitter
- DNAJC16 p.Arg4Thr Uncertain significance Single submitter
- DNAJC16 p.Arg739Gln Uncertain significance Single submitter
- DNAJC16 p.Asn231Lys Uncertain significance Single submitter
- DNAJC16 p.Asn702Ser Uncertain significance Single submitter
- DNAJC16 p.Asn82Asp Uncertain significance Single submitter
- DNAJC16 p.Asp136Tyr Uncertain significance Single submitter
- DNAJC16 p.Asp561Asn Uncertain significance Single submitter
- DNAJC16 p.Asp677Asn Uncertain significance Single submitter
- DNAJC16 p.Asp68Glu Uncertain significance Single submitter
- DNAJC16 p.Cys709Tyr Uncertain significance Single submitter
- DNAJC16 p.Gln348Arg Uncertain significance Single submitter
- DNAJC16 p.Gln414Glu Uncertain significance Single submitter
- DNAJC16 p.Gln99His Uncertain significance Single submitter
- DNAJC16 p.Glu178Asp Uncertain significance Single submitter
- DNAJC16 p.Glu269Lys Uncertain significance Single submitter
- DNAJC16 p.Glu373Gln Uncertain significance Single submitter
- DNAJC16 p.Gly552Ser Uncertain significance Single submitter
- DNAJC16 p.Gly599Ala Uncertain significance Single submitter
- DNAJC16 p.Gly753Glu Uncertain significance Single submitter
- DNAJC16 p.His114Arg Uncertain significance Single submitter
- DNAJC16 p.His208Tyr Uncertain significance Single submitter
- DNAJC16 p.His372Arg Uncertain significance Single submitter
- DNAJC16 p.His381Tyr Uncertain significance Single submitter
- DNAJC16 p.Ile218Val Uncertain significance Single submitter
- DNAJC16 p.Ile221Val Uncertain significance Single submitter
- DNAJC16 p.Ile681Val Uncertain significance Single submitter
- DNAJC16 p.Ile8Thr Uncertain significance Single submitter
- DNAJC16 p.Leu206Gln Uncertain significance Single submitter
- DNAJC16 p.Leu26Ser Uncertain significance Single submitter
- DNAJC16 p.Leu286Ile Uncertain significance Single submitter
- DNAJC16 p.Leu307Val Uncertain significance Single submitter
- DNAJC16 p.Leu374His Uncertain significance Single submitter
- DNAJC16 p.Leu491Phe Uncertain significance Single submitter
- DNAJC16 p.Leu550Phe Uncertain significance Single submitter
- DNAJC16 p.Leu606Phe Uncertain significance Single submitter
- DNAJC16 p.Leu80Phe Uncertain significance Single submitter
- DNAJC16 p.Lys712Gln Uncertain significance Single submitter
- DNAJC16 p.Met345Ile Uncertain significance Single submitter
- DNAJC16 p.Pro570Leu Uncertain significance Single submitter
- DNAJC16 p.Ser173Gly Uncertain significance Single submitter
- DNAJC16 p.Ser660Thr Uncertain significance Single submitter
- DNAJC16 p.Ser769Pro Uncertain significance Single submitter
- DNAJC16 p.Ser9Phe Uncertain significance Single submitter
- DNAJC16 p.Thr167Ile Uncertain significance Single submitter
- DNAJC16 p.Trp170Leu Uncertain significance Single submitter
- DNAJC16 p.Val154Phe Uncertain significance Single submitter
- DNAJC16 p.Val198Ala Uncertain significance Single submitter
- DNAJC16 p.Val556Ile Uncertain significance Single submitter
- DNAJC16 p.Val609Leu Uncertain significance Single submitter
- DNAJC16 p.Val616Leu Uncertain significance Single submitter
- DNAJC16 p.Val626Phe Uncertain significance Single submitter
- DNAJC16 p.Val729Ala Uncertain significance Single submitter
Predictors split 45
The independent predictors disagree with each other — read with care.
- DNAJC16 p.Ala337Gly Uncertain significance Single submitter
- DNAJC16 p.Arg235Cys Uncertain significance Single submitter
- DNAJC16 p.Arg335Gly Uncertain significance Single submitter
- DNAJC16 p.Arg356Gln Likely benign Single submitter
- DNAJC16 p.Arg426Gln Uncertain significance Single submitter
- DNAJC16 p.Arg426Trp Uncertain significance Single submitter
- DNAJC16 p.Arg453His Uncertain significance Single submitter
- DNAJC16 p.Arg54Trp Uncertain significance Single submitter
- DNAJC16 p.Arg617His Uncertain significance Single submitter
- DNAJC16 p.Arg665Thr Uncertain significance Single submitter
- DNAJC16 p.Arg692His Uncertain significance Single submitter
- DNAJC16 p.Asn425Ser Uncertain significance Single submitter
- DNAJC16 p.Asn591Tyr Uncertain significance Single submitter
- DNAJC16 p.Asp296Tyr Uncertain significance Single submitter
- DNAJC16 p.Asp338Asn Uncertain significance Single submitter
- DNAJC16 p.Asp338Tyr Uncertain significance Single submitter
- DNAJC16 p.Asp483His Uncertain significance Single submitter
- DNAJC16 p.Glu183Gly Uncertain significance Single submitter
- DNAJC16 p.His176Leu Uncertain significance Single submitter
- DNAJC16 p.His199Arg Uncertain significance Single submitter
- DNAJC16 p.His664Tyr Uncertain significance Single submitter
- DNAJC16 p.Ile350Thr Uncertain significance Single submitter
- DNAJC16 p.Leu327Phe Uncertain significance Single submitter
- DNAJC16 p.Lys5Glu Uncertain significance Single submitter
- DNAJC16 p.Lys62Arg Uncertain significance Single submitter
- DNAJC16 p.Lys754Asn Uncertain significance Single submitter
- DNAJC16 p.Met345Val Uncertain significance Single submitter
- DNAJC16 p.Phe402Leu Uncertain significance Single submitter
- DNAJC16 p.Pro161Leu Uncertain significance Single submitter
- DNAJC16 p.Ser407Tyr Uncertain significance Single submitter
- DNAJC16 p.Ser445Leu Uncertain significance Single submitter
- DNAJC16 p.Ser473Gly Uncertain significance Single submitter
- DNAJC16 p.Ser738Phe Uncertain significance Single submitter
- DNAJC16 p.Thr255Arg Uncertain significance Single submitter
- DNAJC16 p.Thr280Met Likely benign Single submitter
- DNAJC16 p.Thr416Ile Uncertain significance Single submitter
- DNAJC16 p.Tyr120Cys Uncertain significance Single submitter
- DNAJC16 p.Tyr142Cys Uncertain significance Single submitter
- DNAJC16 p.Tyr481Cys Uncertain significance Single submitter
- DNAJC16 p.Tyr481Ser Uncertain significance Single submitter
- DNAJC16 p.Val251Ala Uncertain significance Single submitter
- DNAJC16 p.Val33Phe Uncertain significance Single submitter
- DNAJC16 p.Val417Gly Uncertain significance Single submitter
- DNAJC16 p.Val447Met Uncertain significance Single submitter
- DNAJC16 p.Val556Phe Uncertain significance Single submitter
All DNAJC16 variants
Likely benign 11
- p.Arg316Gln Single submitter
- p.Arg356Gln Single submitter ⚠
- p.Asn531Ser Single submitter
- p.Asp432Asn Single submitter
- p.Ile282Val Single submitter
- p.Ser560= Single submitter
- p.Ser593= Single submitter
- p.Thr280Met Single submitter ⚠
- p.Thr395Ala Single submitter
- p.Val508Ile Single submitter
- p.Lys400Thr No assertion criteria
Uncertain significance 107
- p.Ala337Gly Single submitter ⚠
- p.Ala53Ser Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Ala95Thr Single submitter ⚠
- p.Arg111His Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg204Lys Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg335Gly Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg364Ser Single submitter ⚠
- p.Arg379Gln Single submitter ⚠
- p.Arg382Gln Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Arg426Trp Single submitter ⚠
- p.Arg453His Single submitter ⚠
- p.Arg486His Single submitter ⚠
- p.Arg4Thr Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg617His Single submitter ⚠
- p.Arg665Thr Single submitter ⚠
- p.Arg692His Single submitter ⚠
- p.Arg739Gln Single submitter ⚠
- p.Asn231Lys Single submitter ⚠
- p.Asn425Ser Single submitter ⚠
- p.Asn591Tyr Single submitter ⚠
- p.Asn702Ser Single submitter ⚠
- p.Asn82Asp Single submitter ⚠
- p.Asp136Tyr Single submitter ⚠
- p.Asp296Tyr Single submitter ⚠
- p.Asp338Asn Single submitter ⚠
- p.Asp338Tyr Single submitter ⚠
- p.Asp483His Single submitter ⚠
- p.Asp561Asn Single submitter ⚠
- p.Asp677Asn Single submitter ⚠
- p.Asp68Glu Single submitter ⚠
- p.Cys709Tyr Single submitter ⚠
- p.Gln348Arg Single submitter ⚠
- p.Gln414Glu Single submitter ⚠
- p.Gln99His Single submitter ⚠
- p.Glu178Asp Single submitter ⚠
- p.Glu183Gly Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu373Gln Single submitter ⚠
- p.Gly552Ser Single submitter ⚠
- p.Gly599Ala Single submitter ⚠
- p.Gly753Glu Single submitter ⚠
- p.His114Arg Single submitter ⚠
- p.His176Leu Single submitter ⚠
- p.His199Arg Single submitter ⚠
- p.His208Tyr Single submitter ⚠
- p.His372Arg Single submitter ⚠
- p.His381Tyr Single submitter ⚠
- p.His664Tyr Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile221Val Single submitter ⚠
- p.Ile350Thr Single submitter ⚠
- p.Ile681Val Single submitter ⚠
- p.Ile8Thr Single submitter ⚠
- p.Leu206Gln Single submitter ⚠
- p.Leu26Ser Single submitter ⚠
- p.Leu286Ile Single submitter ⚠
- p.Leu307Val Single submitter ⚠
- p.Leu327Phe Single submitter ⚠
- p.Leu374His Single submitter ⚠
- p.Leu491Phe Single submitter ⚠
- p.Leu550Phe Single submitter ⚠
- p.Leu606Phe Single submitter ⚠
- p.Leu80Phe Single submitter ⚠
- p.Lys5Glu Single submitter ⚠
- p.Lys62Arg Single submitter ⚠
- p.Lys712Gln Single submitter ⚠
- p.Lys754Asn Single submitter ⚠
- p.Met345Ile Single submitter ⚠
- p.Met345Val Single submitter ⚠
- p.Phe402Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Ser173Gly Single submitter ⚠
- p.Ser407Tyr Single submitter ⚠
- p.Ser445Leu Single submitter ⚠
- p.Ser473Gly Single submitter ⚠
- p.Ser660Thr Single submitter ⚠
- p.Ser738Phe Single submitter ⚠
- p.Ser769Pro Single submitter ⚠
- p.Ser9Phe Single submitter ⚠
- p.Thr167Ile Single submitter ⚠
- p.Thr255Arg Single submitter ⚠
- p.Thr416Ile Single submitter ⚠
- p.Trp170Leu Single submitter ⚠
- p.Tyr120Cys Single submitter ⚠
- p.Tyr142Cys Single submitter ⚠
- p.Tyr481Cys Single submitter ⚠
- p.Tyr481Ser Single submitter ⚠
- p.Val154Phe Single submitter ⚠
- p.Val198Ala Single submitter ⚠
- p.Val251Ala Single submitter ⚠
- p.Val33Phe Single submitter ⚠
- p.Val417Gly Single submitter ⚠
- p.Val447Met Single submitter ⚠
- p.Val556Ile Single submitter ⚠
- p.Val556Phe Single submitter ⚠
- p.Val609Leu Single submitter ⚠
- p.Val616Leu Single submitter ⚠
- p.Val626Phe Single submitter ⚠
- p.Val729Ala Single submitter ⚠