DNAJC2 — 64 ClinVar variants
All ClinVar germline DNAJC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
1 Benign · 63 Uncertain significance
Full DNAJC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC2 p.Ala48Thr Uncertain significance Single submitter
- DNAJC2 p.Arg303Gln Uncertain significance Single submitter
- DNAJC2 p.Arg618Lys Uncertain significance Single submitter
- DNAJC2 p.Asn369Asp Uncertain significance Single submitter
- DNAJC2 p.Asn43Ser Uncertain significance Single submitter
- DNAJC2 p.Asp210Glu Uncertain significance Single submitter
- DNAJC2 p.Asp536Gly Uncertain significance Single submitter
- DNAJC2 p.Asp550Gly Uncertain significance Single submitter
- DNAJC2 p.Asp83Glu Uncertain significance Single submitter
- DNAJC2 p.Asp88Val Uncertain significance Single submitter
- DNAJC2 p.Cys276Arg Uncertain significance Single submitter
- DNAJC2 p.Gln69Lys Uncertain significance Single submitter
- DNAJC2 p.Glu132Gly Uncertain significance Single submitter
- DNAJC2 p.Glu292Ala Uncertain significance Single submitter
- DNAJC2 p.Glu542Gly Uncertain significance Single submitter
- DNAJC2 p.Glu542Lys Uncertain significance Single submitter
- DNAJC2 p.Glu545Ala Uncertain significance Single submitter
- DNAJC2 p.Gly501Ser Uncertain significance Single submitter
- DNAJC2 p.Gly546Val Uncertain significance Single submitter
- DNAJC2 p.His89Leu Uncertain significance Single submitter
- DNAJC2 p.Ile130Val Uncertain significance Single submitter
- DNAJC2 p.Ile349Val Uncertain significance Single submitter
- DNAJC2 p.Ile415Leu Uncertain significance Single submitter
- DNAJC2 p.Lys101Arg Uncertain significance Single submitter
- DNAJC2 p.Lys122Arg Uncertain significance Single submitter
- DNAJC2 p.Lys56Glu Uncertain significance Single submitter
- DNAJC2 p.Lys597Glu Uncertain significance Single submitter
- DNAJC2 p.Lys82Arg Uncertain significance Single submitter
- DNAJC2 p.Met75Leu Uncertain significance Single submitter
- DNAJC2 p.Phe544Val Uncertain significance Single submitter
- DNAJC2 p.Phe551Leu Uncertain significance Single submitter
- DNAJC2 p.Thr552Ser Uncertain significance Single submitter
- DNAJC2 p.Val531Leu Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- DNAJC2 p.Ala308Thr Uncertain significance Single submitter
- DNAJC2 p.Ala436Gly Uncertain significance Single submitter
- DNAJC2 p.Ala616Thr Uncertain significance Single submitter
- DNAJC2 p.Arg105Gly Uncertain significance Single submitter
- DNAJC2 p.Arg321Gln Uncertain significance Single submitter
- DNAJC2 p.Arg386Gln Uncertain significance Single submitter
- DNAJC2 p.Arg432Cys Uncertain significance Single submitter
- DNAJC2 p.Arg432His Uncertain significance Single submitter
- DNAJC2 p.Arg543Gln Uncertain significance Single submitter
- DNAJC2 p.Arg543Leu Uncertain significance Single submitter
- DNAJC2 p.Asp210Asn Uncertain significance Single submitter
- DNAJC2 p.Asp523Gly Uncertain significance Single submitter
- DNAJC2 p.Asp591Asn Uncertain significance Single submitter
- DNAJC2 p.Asp65Gly Uncertain significance Single submitter
- DNAJC2 p.Cys394Trp Uncertain significance Single submitter
- DNAJC2 p.Glu310Asp Uncertain significance Single submitter
- DNAJC2 p.Glu427Lys Uncertain significance Single submitter
- DNAJC2 p.Glu578Gly Uncertain significance Single submitter
- DNAJC2 p.Gly445Asp Uncertain significance Single submitter
- DNAJC2 p.His97Tyr Uncertain significance Single submitter
- DNAJC2 p.Leu599Ile Uncertain significance Single submitter
- DNAJC2 p.Lys281Arg Uncertain significance Single submitter
- DNAJC2 p.Lys295Arg Uncertain significance Single submitter
- DNAJC2 p.Lys413Asn Uncertain significance Single submitter
- DNAJC2 p.Pro574Ser Uncertain significance Single submitter
- DNAJC2 p.Pro574Thr Uncertain significance Single submitter
- DNAJC2 p.Ser490Cys Uncertain significance Single submitter
- DNAJC2 p.Ser490Tyr Uncertain significance Single submitter
- DNAJC2 p.Thr539Met Uncertain significance Single submitter
- DNAJC2 p.Tyr145Phe Uncertain significance Single submitter
All DNAJC2 variants
Benign 1
- p.Thr440= Single submitter
Uncertain significance 63
- p.Ala308Thr Single submitter ⚠
- p.Ala436Gly Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala616Thr Single submitter ⚠
- p.Arg105Gly Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg321Gln Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg432Cys Single submitter ⚠
- p.Arg432His Single submitter ⚠
- p.Arg543Gln Single submitter ⚠
- p.Arg543Leu Single submitter ⚠
- p.Arg618Lys Single submitter ⚠
- p.Asn369Asp Single submitter ⚠
- p.Asn43Ser Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp210Glu Single submitter ⚠
- p.Asp523Gly Single submitter ⚠
- p.Asp536Gly Single submitter ⚠
- p.Asp550Gly Single submitter ⚠
- p.Asp591Asn Single submitter ⚠
- p.Asp65Gly Single submitter ⚠
- p.Asp83Glu Single submitter ⚠
- p.Asp88Val Single submitter ⚠
- p.Cys276Arg Single submitter ⚠
- p.Cys394Trp Single submitter ⚠
- p.Gln69Lys Single submitter ⚠
- p.Glu132Gly Single submitter ⚠
- p.Glu292Ala Single submitter ⚠
- p.Glu310Asp Single submitter ⚠
- p.Glu427Lys Single submitter ⚠
- p.Glu542Gly Single submitter ⚠
- p.Glu542Lys Single submitter ⚠
- p.Glu545Ala Single submitter ⚠
- p.Glu578Gly Single submitter ⚠
- p.Gly445Asp Single submitter ⚠
- p.Gly501Ser Single submitter ⚠
- p.Gly546Val Single submitter ⚠
- p.His89Leu Single submitter ⚠
- p.His97Tyr Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile349Val Single submitter ⚠
- p.Ile415Leu Single submitter ⚠
- p.Leu599Ile Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys122Arg Single submitter ⚠
- p.Lys281Arg Single submitter ⚠
- p.Lys295Arg Single submitter ⚠
- p.Lys413Asn Single submitter ⚠
- p.Lys56Glu Single submitter ⚠
- p.Lys597Glu Single submitter ⚠
- p.Lys82Arg Single submitter ⚠
- p.Met75Leu Single submitter ⚠
- p.Phe544Val Single submitter ⚠
- p.Phe551Leu Single submitter ⚠
- p.Pro574Ser Single submitter ⚠
- p.Pro574Thr Single submitter ⚠
- p.Ser490Cys Single submitter ⚠
- p.Ser490Tyr Single submitter ⚠
- p.Thr539Met Single submitter ⚠
- p.Thr552Ser Single submitter ⚠
- p.Tyr145Phe Single submitter ⚠
- p.Val531Leu Single submitter ⚠