DNAJC27 — 47 ClinVar variants
All ClinVar germline DNAJC27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 45 Uncertain significance
Full DNAJC27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC27 p.Ala264Val Uncertain significance Single submitter
- DNAJC27 p.Ala73Val Uncertain significance Single submitter
- DNAJC27 p.Arg142His Uncertain significance Single submitter
- DNAJC27 p.Arg210Cys Uncertain significance Single submitter
- DNAJC27 p.Arg210His Uncertain significance Single submitter
- DNAJC27 p.Arg213Gly Uncertain significance Single submitter
- DNAJC27 p.Asn263Ser Uncertain significance Single submitter
- DNAJC27 p.Asp97Asn Uncertain significance Single submitter
- DNAJC27 p.Glu38Gly Uncertain significance Single submitter
- DNAJC27 p.Gly168Glu Uncertain significance Single submitter
- DNAJC27 p.Gly170Arg Uncertain significance Single submitter
- DNAJC27 p.His59Pro Uncertain significance Single submitter
- DNAJC27 p.His75Arg Uncertain significance Single submitter
- DNAJC27 p.Ile65Met Uncertain significance Single submitter
- DNAJC27 p.Leu118Phe Uncertain significance Single submitter
- DNAJC27 p.Lys135Glu Uncertain significance Single submitter
- DNAJC27 p.Lys87Arg Uncertain significance Single submitter
- DNAJC27 p.Met22Leu Uncertain significance Single submitter
- DNAJC27 p.Met22Thr Uncertain significance Single submitter
- DNAJC27 p.Phe129Ser Uncertain significance Single submitter
- DNAJC27 p.Thr163Pro Uncertain significance Single submitter
- DNAJC27 p.Tyr79His Uncertain significance Single submitter
- DNAJC27 p.Val183Ala Uncertain significance Single submitter
- DNAJC27 p.Val60Ile Uncertain significance Single submitter
- DNAJC27 p.Val95Phe Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- DNAJC27 p.Ala106Val Uncertain significance Single submitter
- DNAJC27 p.Ala236Val Uncertain significance Single submitter
- DNAJC27 p.Arg150Cys Uncertain significance Single submitter
- DNAJC27 p.Arg192His Uncertain significance Single submitter
- DNAJC27 p.Asp102Asn Uncertain significance Single submitter
- DNAJC27 p.Asp145Gly Uncertain significance Single submitter
- DNAJC27 p.Glu204Lys Uncertain significance Single submitter
- DNAJC27 p.Gly190Arg Uncertain significance Single submitter
- DNAJC27 p.His75Gln Uncertain significance Single submitter
- DNAJC27 p.Leu159Pro Uncertain significance Single submitter
- DNAJC27 p.Leu15Arg Uncertain significance Single submitter
- DNAJC27 p.Leu15His Uncertain significance Single submitter
- DNAJC27 p.Leu240Phe Uncertain significance Single submitter
- DNAJC27 p.Lys270Arg Uncertain significance Single submitter
- DNAJC27 p.Phe178Val Uncertain significance Single submitter
- DNAJC27 p.Ser14Cys Uncertain significance Single submitter
- DNAJC27 p.Ser198Arg Uncertain significance Single submitter
- DNAJC27 p.Ser229Leu Uncertain significance Single submitter
- DNAJC27 p.Val144Leu Uncertain significance Single submitter
- DNAJC27 p.Val19Ile Uncertain significance Single submitter
All DNAJC27 variants
Likely benign 2
- p.Arg13Lys Single submitter
- p.Phe41= Single submitter
Uncertain significance 45
- p.Ala106Val Single submitter ⚠
- p.Ala236Val Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg192His Single submitter ⚠
- p.Arg210Cys Single submitter ⚠
- p.Arg210His Single submitter ⚠
- p.Arg213Gly Single submitter ⚠
- p.Asn263Ser Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp97Asn Single submitter ⚠
- p.Glu204Lys Single submitter ⚠
- p.Glu38Gly Single submitter ⚠
- p.Gly168Glu Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly190Arg Single submitter ⚠
- p.His59Pro Single submitter ⚠
- p.His75Arg Single submitter ⚠
- p.His75Gln Single submitter ⚠
- p.Ile65Met Single submitter ⚠
- p.Leu118Phe Single submitter ⚠
- p.Leu159Pro Single submitter ⚠
- p.Leu15Arg Single submitter ⚠
- p.Leu15His Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Lys135Glu Single submitter ⚠
- p.Lys270Arg Single submitter ⚠
- p.Lys87Arg Single submitter ⚠
- p.Met22Leu Single submitter ⚠
- p.Met22Thr Single submitter ⚠
- p.Phe129Ser Single submitter ⚠
- p.Phe178Val Single submitter ⚠
- p.Ser14Cys Single submitter ⚠
- p.Ser198Arg Single submitter ⚠
- p.Ser229Leu Single submitter ⚠
- p.Thr163Pro Single submitter ⚠
- p.Tyr79His Single submitter ⚠
- p.Val144Leu Single submitter ⚠
- p.Val183Ala Single submitter ⚠
- p.Val19Ile Single submitter ⚠
- p.Val60Ile Single submitter ⚠
- p.Val95Phe Single submitter ⚠