DNAJC28 — 42 ClinVar variants
All ClinVar germline DNAJC28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
4 Likely benign · 38 Uncertain significance
Full DNAJC28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC28 p.Arg310Gln Uncertain significance Single submitter
- DNAJC28 p.Asp329His Uncertain significance Single submitter
- DNAJC28 p.Asp352Val Uncertain significance Single submitter
- DNAJC28 p.Asp88Asn Uncertain significance Single submitter
- DNAJC28 p.Gln10His Uncertain significance Single submitter
- DNAJC28 p.Gln253Glu Uncertain significance Single submitter
- DNAJC28 p.Gln269His Uncertain significance Single submitter
- DNAJC28 p.Glu59Lys Uncertain significance Single submitter
- DNAJC28 p.Gly117Asp Uncertain significance Single submitter
- DNAJC28 p.Gly372Asp Uncertain significance Single submitter
- DNAJC28 p.His133Asn Uncertain significance Single submitter
- DNAJC28 p.Ile196Arg Uncertain significance Single submitter
- DNAJC28 p.Ile200Arg Uncertain significance Single submitter
- DNAJC28 p.Ile267Val Uncertain significance Single submitter
- DNAJC28 p.Ile274Met Uncertain significance Single submitter
- DNAJC28 p.Leu220Phe Uncertain significance Single submitter
- DNAJC28 p.Lys192Arg Uncertain significance Single submitter
- DNAJC28 p.Lys370Arg Uncertain significance Single submitter
- DNAJC28 p.Ser14Ala Uncertain significance Single submitter
- DNAJC28 p.Ser221Ile Uncertain significance Single submitter
- DNAJC28 p.Thr148Ala Uncertain significance Single submitter
- DNAJC28 p.Thr3Ser Uncertain significance Single submitter
- DNAJC28 p.Tyr31His Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DNAJC28 p.Arg134Gln Uncertain significance Single submitter
- DNAJC28 p.Arg202Cys Uncertain significance Single submitter
- DNAJC28 p.Arg202His Uncertain significance Single submitter
- DNAJC28 p.Arg310Gly Uncertain significance Single submitter
- DNAJC28 p.Asn378Asp Uncertain significance Single submitter
- DNAJC28 p.Gln114His Uncertain significance Single submitter
- DNAJC28 p.Glu364Gly Uncertain significance Single submitter
- DNAJC28 p.Glu96Gly Uncertain significance Single submitter
- DNAJC28 p.His105Arg Uncertain significance Single submitter
- DNAJC28 p.Ile22Met Uncertain significance Single submitter
- DNAJC28 p.Ser89Cys Uncertain significance Single submitter
- DNAJC28 p.Thr343Ile Uncertain significance Single submitter
- DNAJC28 p.Tyr178Cys Uncertain significance Single submitter
- DNAJC28 p.Tyr78Cys Uncertain significance Single submitter
All DNAJC28 variants
Likely benign 4
- p.Arg25Gln Single submitter
- p.Arg353Lys Single submitter
- p.Met4Thr Single submitter
- p.Met4Val Single submitter
Uncertain significance 38
- p.Arg134Gln Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg310Gly Single submitter ⚠
- p.Asn378Asp Single submitter ⚠
- p.Asp329His Single submitter ⚠
- p.Asp352Val Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Gln10His Single submitter ⚠
- p.Gln114His Single submitter ⚠
- p.Gln253Glu Single submitter ⚠
- p.Gln269His Single submitter ⚠
- p.Glu168Ter Single submitter
- p.Glu364Gly Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Glu96Gly Single submitter ⚠
- p.Gly117Asp Single submitter ⚠
- p.Gly372Asp Single submitter ⚠
- p.His105Arg Single submitter ⚠
- p.His133Asn Single submitter ⚠
- p.Ile196Arg Single submitter ⚠
- p.Ile200Arg Single submitter ⚠
- p.Ile22Met Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile274Met Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Lys370Arg Single submitter ⚠
- p.Ser14Ala Single submitter ⚠
- p.Ser221Ile Single submitter ⚠
- p.Ser89Cys Single submitter ⚠
- p.Thr148Ala Single submitter ⚠
- p.Thr343Ile Single submitter ⚠
- p.Thr3Ser Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Tyr31His Single submitter ⚠
- p.Tyr78Cys Single submitter ⚠