DNAJC4 — 47 ClinVar variants
All ClinVar germline DNAJC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Likely benign · 45 Uncertain significance
Full DNAJC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC4 p.Ala204Pro Uncertain significance Single submitter
- DNAJC4 p.Arg109Pro Uncertain significance Single submitter
- DNAJC4 p.Arg15Gly Uncertain significance Single submitter
- DNAJC4 p.Arg237Gln Uncertain significance Single submitter
- DNAJC4 p.Arg8Gly Uncertain significance Single submitter
- DNAJC4 p.Arg92Cys Uncertain significance Single submitter
- DNAJC4 p.Arg92His Uncertain significance Single submitter
- DNAJC4 p.Gln141Arg Uncertain significance Single submitter
- DNAJC4 p.Gly231Asp Uncertain significance Single submitter
- DNAJC4 p.Gly240Asp Uncertain significance Single submitter
- DNAJC4 p.Gly40Trp Uncertain significance Single submitter
- DNAJC4 p.His136Gln Uncertain significance Single submitter
- DNAJC4 p.Leu86Pro Uncertain significance Single submitter
- DNAJC4 p.Leu86Val Uncertain significance Single submitter
- DNAJC4 p.Lys177Arg Uncertain significance Single submitter
- DNAJC4 p.Pro3Leu Uncertain significance Single submitter
- DNAJC4 p.Ser19Pro Uncertain significance Single submitter
- DNAJC4 p.Thr47Ser Uncertain significance Single submitter
- DNAJC4 p.Tyr131Phe Uncertain significance Single submitter
- DNAJC4 p.Tyr95Cys Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DNAJC4 p.Ala200Asp Uncertain significance Single submitter
- DNAJC4 p.Ala26Thr Uncertain significance Single submitter
- DNAJC4 p.Arg100Cys Uncertain significance Single submitter
- DNAJC4 p.Arg100His Uncertain significance Single submitter
- DNAJC4 p.Arg201Trp Uncertain significance Single submitter
- DNAJC4 p.Arg203Pro Uncertain significance Single submitter
- DNAJC4 p.Arg215Gly Uncertain significance Single submitter
- DNAJC4 p.Arg217Trp Uncertain significance Single submitter
- DNAJC4 p.Arg237Trp Uncertain significance Single submitter
- DNAJC4 p.Arg31Thr Uncertain significance Single submitter
- DNAJC4 p.Arg75His Uncertain significance Single submitter
- DNAJC4 p.Arg93Cys Uncertain significance Single submitter
- DNAJC4 p.Arg93His Uncertain significance Single submitter
- DNAJC4 p.Cys10Tyr Uncertain significance Single submitter
- DNAJC4 p.Gln98His Uncertain significance Single submitter
- DNAJC4 p.Glu89Gly Uncertain significance Single submitter
- DNAJC4 p.Glu89Lys Uncertain significance Single submitter
- DNAJC4 p.Leu157Pro Uncertain significance Single submitter
- DNAJC4 p.Leu218Pro Uncertain significance Single submitter
- DNAJC4 p.Leu22Phe Likely benign Single submitter
- DNAJC4 p.Met186Thr Uncertain significance Single submitter
- DNAJC4 p.Pro70Arg Uncertain significance Single submitter
- DNAJC4 p.Ser19Tyr Uncertain significance Single submitter
- DNAJC4 p.Tyr131His Uncertain significance Single submitter
- DNAJC4 p.Tyr172Cys Uncertain significance Single submitter
- DNAJC4 p.Val77Leu Uncertain significance Single submitter
All DNAJC4 variants
Likely benign 2
- p.Arg215Gln Single submitter
- p.Leu22Phe Single submitter ⚠
Uncertain significance 45
- p.Ala200Asp Single submitter ⚠
- p.Ala204Pro Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg100His Single submitter ⚠
- p.Arg109Pro Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg203Pro Single submitter ⚠
- p.Arg215Gly Single submitter ⚠
- p.Arg217Trp Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg237Trp Single submitter ⚠
- p.Arg31Thr Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Arg8Gly Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Arg93Cys Single submitter ⚠
- p.Arg93His Single submitter ⚠
- p.Cys10Tyr Single submitter ⚠
- p.Gln141Arg Single submitter ⚠
- p.Gln98His Single submitter ⚠
- p.Glu89Gly Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly231Asp Single submitter ⚠
- p.Gly240Asp Single submitter ⚠
- p.Gly40Trp Single submitter ⚠
- p.His136Gln Single submitter ⚠
- p.Leu157Pro Single submitter ⚠
- p.Leu218Pro Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Lys177Arg Single submitter ⚠
- p.Met186Thr Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Ser19Pro Single submitter ⚠
- p.Ser19Tyr Single submitter ⚠
- p.Thr47Ser Single submitter ⚠
- p.Tyr131His Single submitter ⚠
- p.Tyr131Phe Single submitter ⚠
- p.Tyr172Cys Single submitter ⚠
- p.Tyr95Cys Single submitter ⚠
- p.Val77Leu Single submitter ⚠