DNAJC5B — 16 ClinVar variants
All ClinVar germline DNAJC5B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
2 Likely benign · 14 Uncertain significance
Full DNAJC5B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- DNAJC5B p.Ala19Val Uncertain significance Single submitter
- DNAJC5B p.Arg11Trp Uncertain significance Single submitter
- DNAJC5B p.Cys127Ser Uncertain significance Single submitter
- DNAJC5B p.Glu160Asp Uncertain significance Single submitter
- DNAJC5B p.Gly118Val Uncertain significance Single submitter
- DNAJC5B p.Leu119Phe Uncertain significance Single submitter
- DNAJC5B p.Leu88Val Uncertain significance Single submitter
- DNAJC5B p.Lys163Asn Uncertain significance Single submitter
- DNAJC5B p.Tyr152Cys Uncertain significance Single submitter
- DNAJC5B p.Val90Met Uncertain significance Single submitter
All DNAJC5B variants
Likely benign 2
- p.Ser164Thr Single submitter
- p.Val117Ile Single submitter
Uncertain significance 14
- p.Ala19Val Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Cys127Ser Single submitter ⚠
- p.Glu143Ter Single submitter
- p.Glu160Asp Single submitter ⚠
- p.Gly118Val Single submitter ⚠
- p.Gly87Val Single submitter ⚠
- p.Ile5Met Single submitter ⚠
- p.Ile64Ser Single submitter ⚠
- p.Leu119Phe Single submitter ⚠
- p.Leu88Val Single submitter ⚠
- p.Lys163Asn Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Val90Met Single submitter ⚠