DNAJC5G — 23 ClinVar variants
All ClinVar germline DNAJC5G variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Likely benign · 20 Uncertain significance
Full DNAJC5G gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC5G p.Ala28Ser Uncertain significance Single submitter
- DNAJC5G p.Ala41Ser Uncertain significance Single submitter
- DNAJC5G p.Arg160Lys Uncertain significance Single submitter
- DNAJC5G p.Arg160Ser Uncertain significance Single submitter
- DNAJC5G p.Arg54Lys Uncertain significance Single submitter
- DNAJC5G p.Asp157Ala Uncertain significance Single submitter
- DNAJC5G p.Gly27Asp Uncertain significance Single submitter
- DNAJC5G p.Ile129Val Uncertain significance Single submitter
- DNAJC5G p.Pro30Ser Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DNAJC5G p.Arg10Trp Uncertain significance Single submitter
- DNAJC5G p.Arg59Gln Likely benign Single submitter
- DNAJC5G p.Arg59Trp Uncertain significance Single submitter
- DNAJC5G p.Arg91Gln Uncertain significance Single submitter
- DNAJC5G p.Asn79Ser Uncertain significance Single submitter
- DNAJC5G p.Glu182Lys Uncertain significance Single submitter
- DNAJC5G p.His61Arg Uncertain significance Single submitter
- DNAJC5G p.Leu22Met Uncertain significance Single submitter
- DNAJC5G p.Thr126Lys Uncertain significance Single submitter
- DNAJC5G p.Tyr115Phe Uncertain significance Single submitter
- DNAJC5G p.Tyr19Ser Uncertain significance Single submitter
- DNAJC5G p.Val113Ile Uncertain significance Single submitter
All DNAJC5G variants
Likely benign 3
- p.Arg59Gln Single submitter ⚠
- p.Cys177Gly Single submitter
- p.His9Arg Single submitter
Uncertain significance 20
- p.Ala28Ser Single submitter ⚠
- p.Ala41Ser Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg160Lys Single submitter ⚠
- p.Arg160Ser Single submitter ⚠
- p.Arg54Lys Single submitter ⚠
- p.Arg59Trp Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Asn79Ser Single submitter ⚠
- p.Asp157Ala Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Gly27Asp Single submitter ⚠
- p.His61Arg Single submitter ⚠
- p.Ile129Val Single submitter ⚠
- p.Leu22Met Single submitter ⚠
- p.Pro30Ser Single submitter ⚠
- p.Thr126Lys Single submitter ⚠
- p.Tyr115Phe Single submitter ⚠
- p.Tyr19Ser Single submitter ⚠
- p.Val113Ile Single submitter ⚠