DNAJC7 — 37 ClinVar variants
All ClinVar germline DNAJC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
9 Benign · 1 Likely benign · 27 Uncertain significance
Full DNAJC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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DNAJC7 p.Ala115Pro
Uncertain significance
Single submitter
amyotrophic lateral sclerosis
- DNAJC7 p.Ala141Thr Uncertain significance Single submitter
-
DNAJC7 p.Ala370Val
Uncertain significance
Single submitter
epilepsy
- DNAJC7 p.Ala4Val Uncertain significance Single submitter
- DNAJC7 p.Asn209Ser Uncertain significance Single submitter
- DNAJC7 p.Asn467Asp Uncertain significance Single submitter
- DNAJC7 p.Asp316Tyr Uncertain significance Single submitter
- DNAJC7 p.Gly487Arg Uncertain significance Single submitter
- DNAJC7 p.Ile290Val Uncertain significance Single submitter
- DNAJC7 p.Lys155Arg Uncertain significance Single submitter
- DNAJC7 p.Lys426Glu Uncertain significance Single submitter
-
DNAJC7 p.Met57Thr
Uncertain significance
Single submitter
amyotrophic lateral sclerosis
- DNAJC7 p.Phe171Tyr Uncertain significance Single submitter
- DNAJC7 p.Ser88Ala Uncertain significance Single submitter
- DNAJC7 p.Thr151Arg Uncertain significance Single submitter
- DNAJC7 p.Thr360Arg Uncertain significance Single submitter
- DNAJC7 p.Val234Ile Uncertain significance Single submitter
-
DNAJC7 p.Tyr214Ser
Uncertain significance
No assertion criteria
DNAJC7-related condition
Predictors split 9
The independent predictors disagree with each other — read with care.
- DNAJC7 p.Arg117His Uncertain significance Single submitter
- DNAJC7 p.Arg167Cys Uncertain significance Single submitter
- DNAJC7 p.Arg349Gln Uncertain significance Single submitter
- DNAJC7 p.Asp8Tyr Uncertain significance Single submitter
- DNAJC7 p.Gly475Ser Uncertain significance Single submitter
- DNAJC7 p.Ile55Val Uncertain significance Single submitter
- DNAJC7 p.Met339Val Uncertain significance Single submitter
- DNAJC7 p.Met460Thr Uncertain significance Single submitter
- DNAJC7 p.Tyr297Phe Uncertain significance Single submitter
All DNAJC7 variants
Benign 9
- c.167-65C>A Multiple submitters
- c.406-8C>T Multiple submitters
- c.599+161G>A Multiple submitters
- p.Pro193= Multiple submitters
- c.1447+37A>C Single submitter
- c.166+68del Single submitter
- c.167-194del Single submitter
- c.167-209dup Single submitter
- c.599+41del Single submitter
Likely benign 1
- p.Asn129= Single submitter
Uncertain significance 27
- p.Ala115Pro Single submitter amyotrophic lateral sclerosis ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala370Val Single submitter epilepsy ⚠
- p.Ala4Val Single submitter ⚠
- p.Arg117His Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg349Gln Single submitter ⚠
- p.Asn209Ser Single submitter ⚠
- p.Asn467Asp Single submitter ⚠
- p.Asp316Tyr Single submitter ⚠
- p.Asp8Tyr Single submitter ⚠
- p.Gly475Ser Single submitter ⚠
- p.Gly487Arg Single submitter ⚠
- p.Ile290Val Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Lys155Arg Single submitter ⚠
- p.Lys426Glu Single submitter ⚠
- p.Met339Val Single submitter ⚠
- p.Met460Thr Single submitter ⚠
- p.Met57Thr Single submitter amyotrophic lateral sclerosis ⚠
- p.Phe171Tyr Single submitter ⚠
- p.Ser88Ala Single submitter ⚠
- p.Thr151Arg Single submitter ⚠
- p.Thr360Arg Single submitter ⚠
- p.Tyr297Phe Single submitter ⚠
- p.Val234Ile Single submitter ⚠
- p.Tyr214Ser No assertion criteria DNAJC7-related condition ⚠