DNAJC8 — 21 ClinVar variants
All ClinVar germline DNAJC8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
21 Uncertain significance
Full DNAJC8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNAJC8 p.Ala93Val Uncertain significance Single submitter
- DNAJC8 p.Asp92Val Uncertain significance Single submitter
- DNAJC8 p.Gly14Asp Uncertain significance Single submitter
- DNAJC8 p.Gly5Ala Uncertain significance Single submitter
- DNAJC8 p.Ser15Gly Uncertain significance Single submitter
- DNAJC8 p.Ser4Ala Uncertain significance Single submitter
- DNAJC8 p.Thr16Ile Uncertain significance Single submitter
- DNAJC8 p.Thr230Arg Uncertain significance Single submitter
- DNAJC8 p.Thr9Ser Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- DNAJC8 p.Ala161Thr Uncertain significance Single submitter
- DNAJC8 p.Arg95Gly Uncertain significance Single submitter
- DNAJC8 p.Asn55Ser Uncertain significance Single submitter
- DNAJC8 p.Glu179Asp Uncertain significance Single submitter
- DNAJC8 p.Glu67Lys Uncertain significance Single submitter
- DNAJC8 p.Gly11Asp Uncertain significance Single submitter
- DNAJC8 p.Gly218Asp Uncertain significance Single submitter
- DNAJC8 p.Gly8Arg Uncertain significance Single submitter
- DNAJC8 p.Lys146Asn Uncertain significance Single submitter
- DNAJC8 p.Pro49Ala Uncertain significance Single submitter
- DNAJC8 p.Ser10Leu Uncertain significance Single submitter
- DNAJC8 p.Ser7Arg Uncertain significance Single submitter
All DNAJC8 variants
Uncertain significance 21
- p.Ala161Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg95Gly Single submitter ⚠
- p.Asn55Ser Single submitter ⚠
- p.Asp92Val Single submitter ⚠
- p.Glu179Asp Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly218Asp Single submitter ⚠
- p.Gly5Ala Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.Lys146Asn Single submitter ⚠
- p.Pro49Ala Single submitter ⚠
- p.Ser10Leu Single submitter ⚠
- p.Ser15Gly Single submitter ⚠
- p.Ser4Ala Single submitter ⚠
- p.Ser7Arg Single submitter ⚠
- p.Thr16Ile Single submitter ⚠
- p.Thr230Arg Single submitter ⚠
- p.Thr9Ser Single submitter ⚠