DNASE2B — 34 ClinVar variants
All ClinVar germline DNASE2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
34 Uncertain significance
Full DNASE2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNASE2B p.Ala216Thr Uncertain significance Single submitter
- DNASE2B p.Asn104Thr Uncertain significance Single submitter
- DNASE2B p.Asn111Thr Uncertain significance Single submitter
- DNASE2B p.Asp304Glu Uncertain significance Single submitter
- DNASE2B p.Cys309Tyr Uncertain significance Single submitter
- DNASE2B p.Cys360Tyr Uncertain significance Single submitter
- DNASE2B p.Gln312Glu Uncertain significance Single submitter
- DNASE2B p.Gln345Lys Uncertain significance Single submitter
- DNASE2B p.Glu205Gly Uncertain significance Single submitter
- DNASE2B p.His284Arg Uncertain significance Single submitter
- DNASE2B p.His284Gln Uncertain significance Single submitter
- DNASE2B p.Lys123Thr Uncertain significance Single submitter
- DNASE2B p.Pro117Ala Uncertain significance Single submitter
- DNASE2B p.Pro146Ala Uncertain significance Single submitter
- DNASE2B p.Pro159Arg Uncertain significance Single submitter
- DNASE2B p.Ser294Thr Uncertain significance Single submitter
- DNASE2B p.Thr127Ser Uncertain significance Single submitter
- DNASE2B p.Trp308Arg Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DNASE2B p.Arg270Gln Uncertain significance Single submitter
- DNASE2B p.Arg327Gln Uncertain significance Single submitter
- DNASE2B p.Asn278Ile Uncertain significance Single submitter
- DNASE2B p.Asn287Ser Uncertain significance Single submitter
- DNASE2B p.Asp244Val Uncertain significance Single submitter
- DNASE2B p.Gly138Ala Uncertain significance Single submitter
- DNASE2B p.Gly314Ser Uncertain significance Single submitter
- DNASE2B p.His208Pro Uncertain significance Single submitter
- DNASE2B p.Ile142Ser Uncertain significance Single submitter
- DNASE2B p.Ile172Met Uncertain significance Single submitter
- DNASE2B p.Ile322Val Uncertain significance Single submitter
- DNASE2B p.Ile346Thr Uncertain significance Single submitter
- DNASE2B p.Leu238Phe Uncertain significance Single submitter
- DNASE2B p.Tyr107Cys Uncertain significance Single submitter
- DNASE2B p.Tyr110Cys Uncertain significance Single submitter
- DNASE2B p.Tyr46His Uncertain significance Single submitter
All DNASE2B variants
Uncertain significance 34
- p.Ala216Thr Single submitter ⚠
- p.Arg270Gln Single submitter ⚠
- p.Arg327Gln Single submitter ⚠
- p.Asn104Thr Single submitter ⚠
- p.Asn111Thr Single submitter ⚠
- p.Asn278Ile Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asp244Val Single submitter ⚠
- p.Asp304Glu Single submitter ⚠
- p.Cys309Tyr Single submitter ⚠
- p.Cys360Tyr Single submitter ⚠
- p.Gln312Glu Single submitter ⚠
- p.Gln345Lys Single submitter ⚠
- p.Glu205Gly Single submitter ⚠
- p.Gly138Ala Single submitter ⚠
- p.Gly314Ser Single submitter ⚠
- p.His208Pro Single submitter ⚠
- p.His284Arg Single submitter ⚠
- p.His284Gln Single submitter ⚠
- p.Ile142Ser Single submitter ⚠
- p.Ile172Met Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Ile346Thr Single submitter ⚠
- p.Leu238Phe Single submitter ⚠
- p.Lys123Thr Single submitter ⚠
- p.Pro117Ala Single submitter ⚠
- p.Pro146Ala Single submitter ⚠
- p.Pro159Arg Single submitter ⚠
- p.Ser294Thr Single submitter ⚠
- p.Thr127Ser Single submitter ⚠
- p.Trp308Arg Single submitter ⚠
- p.Tyr107Cys Single submitter ⚠
- p.Tyr110Cys Single submitter ⚠
- p.Tyr46His Single submitter ⚠