DND1 — 57 ClinVar variants
All ClinVar germline DND1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 56 Uncertain significance
Full DND1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DND1 p.Ala177Val Uncertain significance Single submitter
- DND1 p.Ala182Val Uncertain significance Single submitter
- DND1 p.Ala20Thr Uncertain significance Single submitter
- DND1 p.Ala212Val Uncertain significance Single submitter
- DND1 p.Ala244Pro Uncertain significance Single submitter
- DND1 p.Ala345Val Uncertain significance Single submitter
- DND1 p.Arg13Lys Uncertain significance Single submitter
- DND1 p.Arg223Gln Uncertain significance Single submitter
- DND1 p.Arg225Cys Uncertain significance Single submitter
- DND1 p.Arg287Cys Uncertain significance Single submitter
- DND1 p.Arg314Trp Uncertain significance Single submitter
- DND1 p.Arg327Trp Uncertain significance Single submitter
- DND1 p.Arg32Gly Uncertain significance Single submitter
- DND1 p.Arg32His Uncertain significance Single submitter
- DND1 p.Cys11Trp Uncertain significance Single submitter
- DND1 p.Cys277Tyr Uncertain significance Single submitter
- DND1 p.Gln166Glu Uncertain significance Single submitter
- DND1 p.Gln253Arg Uncertain significance Single submitter
- DND1 p.Gln2Arg Uncertain significance Single submitter
- DND1 p.Gln35Leu Uncertain significance Single submitter
- DND1 p.Glu167Asp Uncertain significance Single submitter
- DND1 p.Gly162Ala Uncertain significance Single submitter
- DND1 p.Gly281Glu Uncertain significance Single submitter
- DND1 p.Gly296Arg Uncertain significance Single submitter
- DND1 p.Gly313Cys Uncertain significance Single submitter
- DND1 p.His205Tyr Uncertain significance Single submitter
- DND1 p.His286Tyr Uncertain significance Single submitter
- DND1 p.His317Gln Uncertain significance Single submitter
- DND1 p.Ile305Phe Uncertain significance Single submitter
- DND1 p.Leu156Val Uncertain significance Single submitter
- DND1 p.Leu304Val Uncertain significance Single submitter
- DND1 p.Leu339Phe Uncertain significance Single submitter
- DND1 p.Lys276Arg Uncertain significance Single submitter
- DND1 p.Pro122Ser Uncertain significance Single submitter
- DND1 p.Pro128Ser Uncertain significance Single submitter
- DND1 p.Pro147Arg Uncertain significance Single submitter
- DND1 p.Pro160Leu Uncertain significance Single submitter
- DND1 p.Pro174Leu Uncertain significance Single submitter
- DND1 p.Pro176Arg Uncertain significance Single submitter
- DND1 p.Pro231Leu Uncertain significance Single submitter
- DND1 p.Pro298Ser Uncertain significance Single submitter
- DND1 p.Ser126Cys Uncertain significance Single submitter
- DND1 p.Ser126Tyr Uncertain significance Single submitter
- DND1 p.Ser333Thr Uncertain significance Single submitter
- DND1 p.Val326Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DND1 p.Ala157Val Uncertain significance Single submitter
- DND1 p.Arg83Gly Uncertain significance Single submitter
- DND1 p.Gly63Arg Uncertain significance Single submitter
- DND1 p.Leu149Pro Uncertain significance Single submitter
- DND1 p.Leu154Met Uncertain significance Single submitter
- DND1 p.Leu259Val Uncertain significance Single submitter
- DND1 p.Phe78Leu Uncertain significance Single submitter
- DND1 p.Ser302Arg Uncertain significance Single submitter
- DND1 p.Ser325Tyr Uncertain significance Single submitter
All DND1 variants
Likely benign 1
- p.Arg234Gln Single submitter
Uncertain significance 56
- p.Ala157Val Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala195Thr Single submitter
- p.Ala20Thr Single submitter ⚠
- p.Ala212Val Single submitter ⚠
- p.Ala244Pro Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Arg13Lys Single submitter ⚠
- p.Arg223Gln Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg314Trp Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg32Gly Single submitter ⚠
- p.Arg32His Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Cys11Trp Single submitter ⚠
- p.Cys277Tyr Single submitter ⚠
- p.Gln166Glu Single submitter ⚠
- p.Gln253Arg Single submitter ⚠
- p.Gln2Arg Single submitter ⚠
- p.Gln35Leu Single submitter ⚠
- p.Glu167Asp Single submitter ⚠
- p.Gly162Ala Single submitter ⚠
- p.Gly281Glu Single submitter ⚠
- p.Gly296Arg Single submitter ⚠
- p.Gly313Cys Single submitter ⚠
- p.Gly51Ser Single submitter
- p.Gly63Arg Single submitter ⚠
- p.His205Tyr Single submitter ⚠
- p.His286Tyr Single submitter ⚠
- p.His317Gln Single submitter ⚠
- p.Ile305Phe Single submitter ⚠
- p.Leu149Pro Single submitter ⚠
- p.Leu154Met Single submitter ⚠
- p.Leu156Val Single submitter ⚠
- p.Leu259Val Single submitter ⚠
- p.Leu304Val Single submitter ⚠
- p.Leu339Phe Single submitter ⚠
- p.Lys276Arg Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro122Ser Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro176Arg Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro298Ser Single submitter ⚠
- p.Ser126Cys Single submitter ⚠
- p.Ser126Tyr Single submitter ⚠
- p.Ser302Arg Single submitter ⚠
- p.Ser325Tyr Single submitter ⚠
- p.Ser333Thr Single submitter ⚠
- p.Val326Ile Single submitter ⚠