DNER — 122 ClinVar variants
All ClinVar germline DNER variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
9 Benign · 7 Likely benign · 106 Uncertain significance
Full DNER gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNER p.Ala171Thr Uncertain significance Single submitter
- DNER p.Ala205Thr Uncertain significance Single submitter
- DNER p.Ala234Thr Uncertain significance Single submitter
- DNER p.Ala362Val Uncertain significance Single submitter
- DNER p.Ala478Ser Uncertain significance Single submitter
- DNER p.Ala512Thr Uncertain significance Single submitter
- DNER p.Ala649Thr Uncertain significance Single submitter
- DNER p.Ala709Thr Uncertain significance Single submitter
- DNER p.Ala717Thr Uncertain significance Single submitter
- DNER p.Ala8Val Uncertain significance Single submitter
- DNER p.Arg151Gln Uncertain significance Single submitter
- DNER p.Arg214His Uncertain significance Single submitter
- DNER p.Arg297His Uncertain significance Single submitter
- DNER p.Arg483His Uncertain significance Single submitter
- DNER p.Arg663Pro Uncertain significance Single submitter
- DNER p.Arg666Cys Uncertain significance Single submitter
- DNER p.Arg698Gln Uncertain significance Single submitter
- DNER p.Arg707Trp Uncertain significance Single submitter
- DNER p.Asn124Lys Uncertain significance Single submitter
- DNER p.Asn223Ser Uncertain significance Single submitter
- DNER p.Asn315Thr Uncertain significance Single submitter
- DNER p.Asn682Asp Uncertain significance Single submitter
- DNER p.Asn682Ser Uncertain significance Single submitter
- DNER p.Asp117Asn Uncertain significance Single submitter
- DNER p.Asp316Gly Uncertain significance Single submitter
- DNER p.Asp351Asn Uncertain significance Single submitter
- DNER p.Asp394Asn Uncertain significance Single submitter
- DNER p.Asp448Glu Uncertain significance Single submitter
- DNER p.Asp598Glu Uncertain significance Single submitter
- DNER p.Cys132Ser Uncertain significance Single submitter
- DNER p.Cys336Arg Uncertain significance Single submitter
- DNER p.Cys336Phe Uncertain significance Single submitter
- DNER p.Cys567Arg Uncertain significance Single submitter
- DNER p.Gln134His Uncertain significance Single submitter
- DNER p.Gln371Lys Uncertain significance Single submitter
- DNER p.Gln68Arg Uncertain significance Single submitter
- DNER p.Glu349Ala Uncertain significance Single submitter
- DNER p.Glu689Lys Uncertain significance Single submitter
- DNER p.Gly212Asp Uncertain significance Single submitter
- DNER p.Gly213Ser Uncertain significance Single submitter
- DNER p.Gly30Arg Uncertain significance Single submitter
- DNER p.Gly462Glu Uncertain significance Single submitter
- DNER p.Gly572Arg Uncertain significance Single submitter
- DNER p.Gly625Arg Uncertain significance Single submitter
- DNER p.His313Gln Uncertain significance Single submitter
- DNER p.His609Arg Uncertain significance Single submitter
- DNER p.His619Leu Uncertain significance Single submitter
- DNER p.His69Gln Uncertain significance Single submitter
- DNER p.Ile655Ser Uncertain significance Single submitter
- DNER p.Leu153Arg Uncertain significance Single submitter
- DNER p.Leu388Phe Uncertain significance Single submitter
- DNER p.Leu411Val Uncertain significance Single submitter
- DNER p.Leu492Phe Uncertain significance Single submitter
- DNER p.Leu631Phe Uncertain significance Single submitter
- DNER p.Lys241Thr Uncertain significance Single submitter
- DNER p.Lys392Arg Uncertain significance Single submitter
- DNER p.Pro28Leu Uncertain significance Single submitter
- DNER p.Pro309Leu Uncertain significance Single submitter
- DNER p.Pro309Ser Uncertain significance Single submitter
- DNER p.Pro329Leu Uncertain significance Single submitter
- DNER p.Pro36Ala Uncertain significance Single submitter
- DNER p.Ser257Asn Uncertain significance Single submitter
- DNER p.Ser374Arg Uncertain significance Single submitter
- DNER p.Thr259Ile Uncertain significance Single submitter
- DNER p.Tyr119Asp Uncertain significance Single submitter
- DNER p.Val308Leu Uncertain significance Single submitter
Predictors split 41
The independent predictors disagree with each other — read with care.
- DNER p.Thr142Ile Benign Multiple submitters
- DNER p.Ala11Val Uncertain significance Single submitter
- DNER p.Ala362Thr Uncertain significance Single submitter
- DNER p.Arg168Cys Uncertain significance Single submitter
- DNER p.Arg214Cys Uncertain significance Single submitter
- DNER p.Arg29Gln Uncertain significance Single submitter
- DNER p.Arg636Trp Uncertain significance Single submitter
- DNER p.Asn525Ser Uncertain significance Single submitter
- DNER p.Asn549Lys Uncertain significance Single submitter
- DNER p.Asn583Ser Uncertain significance Single submitter
- DNER p.Asn601Ile Uncertain significance Single submitter
- DNER p.Asp351Val Uncertain significance Single submitter
- DNER p.Asp432Asn Uncertain significance Single submitter
- DNER p.Gln354Pro Uncertain significance Single submitter
- DNER p.Glu339Val Uncertain significance Single submitter
- DNER p.Gly126Arg Uncertain significance Single submitter
- DNER p.Gly449Arg Uncertain significance Single submitter
- DNER p.Gly56Arg Uncertain significance Single submitter
- DNER p.Gly77Ser Uncertain significance Single submitter
- DNER p.His280Leu Uncertain significance Single submitter
- DNER p.His479Tyr Uncertain significance Single submitter
- DNER p.Ile282Val Uncertain significance Single submitter
- DNER p.Ile293Thr Uncertain significance Single submitter
- DNER p.Ile582Leu Uncertain significance Single submitter
- DNER p.Leu215Arg Uncertain significance Single submitter
- DNER p.Leu317Met Uncertain significance Single submitter
- DNER p.Lys735Asn Uncertain significance Single submitter
- DNER p.Met710Lys Uncertain significance Single submitter
- DNER p.Pro102Ser Uncertain significance Single submitter
- DNER p.Pro3Leu Uncertain significance Single submitter
- DNER p.Pro67Ser Uncertain significance Single submitter
- DNER p.Pro727Arg Uncertain significance Single submitter
- DNER p.Ser113Arg Uncertain significance Single submitter
- DNER p.Ser147Phe Uncertain significance Single submitter
- DNER p.Ser206Asn Uncertain significance Single submitter
- DNER p.Ser217Phe Uncertain significance Single submitter
- DNER p.Ser32Phe Uncertain significance Single submitter
- DNER p.Ser363Asn Uncertain significance Single submitter
- DNER p.Ser436Leu Uncertain significance Single submitter
- DNER p.Thr333Ile Uncertain significance Single submitter
- DNER p.Trp622Cys Uncertain significance Single submitter
All DNER variants
Benign 9
- c.586-10C>T Multiple submitters
- p.Arg698= Multiple submitters
- p.Pro180= Multiple submitters
- p.Thr142Ile Multiple submitters ⚠
- c.586-10dup Single submitter
- p.Cys434= Single submitter
- p.Gln621= Single submitter
- p.Ser560= Single submitter
- p.Ser624= Single submitter
Likely benign 7
- p.Ala211= Single submitter
- p.Ala39= Single submitter
- p.Arg168His Single submitter
- p.Met627Val Single submitter
- p.Thr142Ser Single submitter
- p.Thr145= Single submitter
- p.Thr481= Single submitter
Uncertain significance 106
- p.Ala11Val Single submitter ⚠
- p.Ala171Thr Single submitter ⚠
- p.Ala205Thr Single submitter ⚠
- p.Ala234Thr Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala478Ser Single submitter ⚠
- p.Ala512Thr Single submitter ⚠
- p.Ala649Thr Single submitter ⚠
- p.Ala709Thr Single submitter ⚠
- p.Ala717Thr Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg214Cys Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg297His Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Arg483His Single submitter ⚠
- p.Arg636Trp Single submitter ⚠
- p.Arg663Pro Single submitter ⚠
- p.Arg666Cys Single submitter ⚠
- p.Arg698Gln Single submitter ⚠
- p.Arg707Trp Single submitter ⚠
- p.Asn124Lys Single submitter ⚠
- p.Asn223Ser Single submitter ⚠
- p.Asn315Thr Single submitter ⚠
- p.Asn525Ser Single submitter ⚠
- p.Asn549Lys Single submitter ⚠
- p.Asn583Ser Single submitter ⚠
- p.Asn601Ile Single submitter ⚠
- p.Asn682Asp Single submitter ⚠
- p.Asn682Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp316Gly Single submitter ⚠
- p.Asp351Asn Single submitter ⚠
- p.Asp351Val Single submitter ⚠
- p.Asp394Asn Single submitter ⚠
- p.Asp432Asn Single submitter ⚠
- p.Asp448Glu Single submitter ⚠
- p.Asp598Glu Single submitter ⚠
- p.Cys132Ser Single submitter ⚠
- p.Cys336Arg Single submitter ⚠
- p.Cys336Phe Single submitter ⚠
- p.Cys567Arg Single submitter ⚠
- p.Gln134His Single submitter ⚠
- p.Gln354Pro Single submitter ⚠
- p.Gln371Lys Single submitter ⚠
- p.Gln68Arg Single submitter ⚠
- p.Glu339Val Single submitter ⚠
- p.Glu349Ala Single submitter ⚠
- p.Glu689Lys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly212Asp Single submitter ⚠
- p.Gly213Ser Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly449Arg Single submitter ⚠
- p.Gly462Glu Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Gly572Arg Single submitter ⚠
- p.Gly625Arg Single submitter ⚠
- p.Gly77Ser Single submitter ⚠
- p.His280Leu Single submitter ⚠
- p.His313Gln Single submitter ⚠
- p.His479Tyr Single submitter ⚠
- p.His609Arg Single submitter ⚠
- p.His619Leu Single submitter ⚠
- p.His69Gln Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile293Thr Single submitter ⚠
- p.Ile582Leu Single submitter ⚠
- p.Ile655Ser Single submitter ⚠
- p.Leu153Arg Single submitter ⚠
- p.Leu215Arg Single submitter ⚠
- p.Leu317Met Single submitter ⚠
- p.Leu388Phe Single submitter ⚠
- p.Leu411Val Single submitter ⚠
- p.Leu492Phe Single submitter ⚠
- p.Leu631Phe Single submitter ⚠
- p.Lys241Thr Single submitter ⚠
- p.Lys392Arg Single submitter ⚠
- p.Lys735Asn Single submitter ⚠
- p.Met710Lys Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro309Leu Single submitter ⚠
- p.Pro309Ser Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Pro36Ala Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Pro67Ser Single submitter ⚠
- p.Pro727Arg Single submitter ⚠
- p.Ser113Arg Single submitter ⚠
- p.Ser147Phe Single submitter ⚠
- p.Ser206Asn Single submitter ⚠
- p.Ser217Phe Single submitter ⚠
- p.Ser257Asn Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Ser363Asn Single submitter ⚠
- p.Ser374Arg Single submitter ⚠
- p.Ser436Leu Single submitter ⚠
- p.Thr259Ile Single submitter ⚠
- p.Thr333Ile Single submitter ⚠
- p.Trp622Cys Single submitter ⚠
- p.Tyr119Asp Single submitter ⚠
- p.Val308Leu Single submitter ⚠