DNM3 — 98 ClinVar variants

All ClinVar germline DNM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →

2 Benign · 10 Likely benign · 86 Uncertain significance

Full DNM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 80

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 62

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 18

The independent predictors disagree with each other — read with care.

All DNM3 variants

Benign 2

p.Asn686= Multiple submitters
p.Thr833= Multiple submitters

Likely benign 10

c.1422+8G>T Single submitter
c.1546-4G>A Single submitter
c.1546-7T>C Single submitter
p.Ala781Thr Single submitter
p.Glu554= Single submitter
p.Gly786= Single submitter
p.Leu446= Single submitter
p.Pro263= Single submitter
p.Pro319Gln Single submitter
p.Ser817Asn Single submitter

Uncertain significance 86

p.Arg290Gln Multiple submitters ⚠
p.Ala19Val Single submitter
p.Ala254Ser Single submitter ⚠
p.Ala254Thr Single submitter ⚠
p.Ala313Thr Single submitter ⚠
p.Ala337Ser Single submitter ⚠
p.Ala781Ser Single submitter ⚠
p.Arg157Ile Single submitter ⚠
p.Arg228Cys Single submitter ⚠
p.Arg228His Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg465His Single submitter ⚠
p.Arg4Leu Single submitter ⚠
p.Arg597Cys Single submitter ⚠
p.Arg657His Single submitter ⚠
p.Arg719Trp Single submitter ⚠
p.Arg761His Single submitter ⚠
p.Arg842Trp Single submitter ⚠
p.Arg850His Single submitter ⚠
p.Asn686His Single submitter ⚠
p.Asp147Tyr Single submitter ⚠
p.Asp473Asn Single submitter ⚠
p.Gln239Arg Single submitter ⚠
p.Gln715Leu Single submitter ⚠
p.Glu387Gln Single submitter ⚠
p.Glu466Lys Single submitter ⚠
p.Glu8Gly Single submitter ⚠
p.Gly358Ser Single submitter ⚠
p.Gly786Ser Single submitter ⚠
p.His267Arg Single submitter ⚠
p.His799Asn Single submitter ⚠
p.Ile242Thr Single submitter ⚠
p.Ile242Val Single submitter
p.Ile365Val Single submitter ⚠
p.Ile398Val Single submitter ⚠
p.Ile527Thr Single submitter ⚠
p.Ile666Leu Single submitter ⚠
p.Ile853Thr Single submitter ⚠
p.Leu305Pro Single submitter ⚠
p.Leu452Val Single submitter ⚠
p.Leu57Phe Single submitter ⚠
p.Leu733Phe Single submitter ⚠
p.Leu73Phe Single submitter ⚠
p.Lys240Arg Single submitter ⚠
p.Lys315Thr Single submitter ⚠
p.Lys421Glu Single submitter
p.Lys557Arg Single submitter ⚠
p.Lys89Arg Single submitter ⚠
p.Met161Ile Single submitter ⚠
p.Met332Ile Single submitter ⚠
p.Met664Val Single submitter ⚠
p.Met709Ile Single submitter ⚠
p.Phe822Leu Single submitter ⚠
p.Pro263Leu Single submitter ⚠
p.Pro423Ala Single submitter ⚠
p.Pro68Thr Single submitter ⚠
p.Pro747Leu Single submitter ⚠
p.Pro750Arg Single submitter ⚠
p.Pro751Ser Single submitter ⚠
p.Pro765Ala Single submitter ⚠
p.Pro779Leu Single submitter ⚠
p.Pro779Ser Single submitter ⚠
p.Pro798Thr Single submitter ⚠
p.Pro806Ser Single submitter
p.Pro845Leu Single submitter ⚠
p.Ser427Cys Single submitter ⚠
p.Ser503Cys Single submitter ⚠
p.Ser61Leu Single submitter ⚠
p.Ser859Phe Single submitter ⚠
p.Thr141Ser Single submitter ⚠
p.Thr165Met Single submitter ⚠
p.Thr770Ala Single submitter ⚠
p.Thr849Ser Single submitter ⚠
p.Thr852Ser Single submitter ⚠
p.Tyr125Cys Single submitter ⚠
p.Tyr154His Single submitter ⚠
p.Tyr549Phe Single submitter ⚠
p.Tyr700Cys Single submitter ⚠
p.Val145Ala Single submitter ⚠
p.Val232Met Single submitter
p.Val280Ala Single submitter ⚠
p.Val475Ile Single submitter ⚠
p.Val540Ile Single submitter ⚠
p.Val744Leu Single submitter ⚠
p.Val744Met Single submitter ⚠
p.Lys376Gln No assertion criteria DNM3-related condition