DNMT3L — 71 ClinVar variants
All ClinVar germline DNMT3L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
6 Likely benign · 65 Uncertain significance
Full DNMT3L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNMT3L p.Ala244Thr Uncertain significance Single submitter
- DNMT3L p.Ala270Thr Uncertain significance Single submitter
- DNMT3L p.Ala2Val Uncertain significance Single submitter
- DNMT3L p.Ala356Val Uncertain significance Single submitter
- DNMT3L p.Arg158Lys Uncertain significance Single submitter
- DNMT3L p.Arg161His Uncertain significance Single submitter
- DNMT3L p.Arg265Trp Uncertain significance Single submitter
- DNMT3L p.Arg322Cys Uncertain significance Single submitter
- DNMT3L p.Asn287Tyr Uncertain significance Single submitter
- DNMT3L p.Asn366Lys Uncertain significance Single submitter
- DNMT3L p.Asp169Asn Uncertain significance Single submitter
- DNMT3L p.Asp226Val Uncertain significance Single submitter
- DNMT3L p.Gln188Arg Uncertain significance Single submitter
- DNMT3L p.Glu103Asp Uncertain significance Single submitter
- DNMT3L p.Glu120Lys Uncertain significance Single submitter
- DNMT3L p.Glu171Val Uncertain significance Single submitter
- DNMT3L p.Glu180Ala Uncertain significance Single submitter
- DNMT3L p.Glu180Asp Uncertain significance Single submitter
- DNMT3L p.Gly109Arg Uncertain significance Single submitter
- DNMT3L p.Gly127Ser Uncertain significance Single submitter
- DNMT3L p.Gly249Ala Uncertain significance Single submitter
- DNMT3L p.Gly314Ser Uncertain significance Single submitter
- DNMT3L p.Gly34Asp Uncertain significance Single submitter
- DNMT3L p.Gly91Val Uncertain significance Single submitter
- DNMT3L p.His220Arg Uncertain significance Single submitter
- DNMT3L p.His264Gln Uncertain significance Single submitter
- DNMT3L p.Ile49Val Uncertain significance Single submitter
- DNMT3L p.Leu25Ile Uncertain significance Single submitter
- DNMT3L p.Leu382Val Uncertain significance Single submitter
- DNMT3L p.Leu7Arg Uncertain significance Single submitter
- DNMT3L p.Met15Ile Uncertain significance Single submitter
- DNMT3L p.Met15Leu Uncertain significance Single submitter
- DNMT3L p.Met15Val Uncertain significance Single submitter
- DNMT3L p.Met283Ile Uncertain significance Single submitter
- DNMT3L p.Pro147Ser Uncertain significance Single submitter
- DNMT3L p.Pro215Leu Uncertain significance Single submitter
- DNMT3L p.Pro247Thr Uncertain significance Single submitter
- DNMT3L p.Pro256Ala Uncertain significance Single submitter
- DNMT3L p.Ser27Arg Uncertain significance Single submitter
- DNMT3L p.Ser339Leu Uncertain significance Single submitter
- DNMT3L p.Ser353Leu Uncertain significance Single submitter
- DNMT3L p.Thr63Ile Uncertain significance Single submitter
- DNMT3L p.Trp140Gly Uncertain significance Single submitter
- DNMT3L p.Trp160Cys Uncertain significance Single submitter
- DNMT3L p.Trp282Cys Uncertain significance Single submitter
- DNMT3L p.Tyr117His Uncertain significance Single submitter
- DNMT3L p.Val122Met Uncertain significance Single submitter
- DNMT3L p.Val126Ile Uncertain significance Single submitter
- DNMT3L p.Val17Met Uncertain significance Single submitter
- DNMT3L p.Val184Met Uncertain significance Single submitter
- DNMT3L p.Val289Met Uncertain significance Single submitter
- DNMT3L p.Val29Ile Uncertain significance Single submitter
- DNMT3L p.Val307Leu Uncertain significance Single submitter
- DNMT3L p.Val323Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DNMT3L p.Arg161Ser Uncertain significance Single submitter
- DNMT3L p.Arg254Cys Uncertain significance Single submitter
- DNMT3L p.Arg271Trp Uncertain significance Single submitter
- DNMT3L p.Arg47Gln Uncertain significance Single submitter
- DNMT3L p.Ser194Thr Uncertain significance Single submitter
- DNMT3L p.Ser339Trp Uncertain significance Single submitter
- DNMT3L p.Trp185Cys Uncertain significance Single submitter
- DNMT3L p.Tyr92Cys Uncertain significance Single submitter
All DNMT3L variants
Likely benign 6
- p.Ala74Thr Single submitter
- p.Arg322His Single submitter
- p.Arg331Lys Single submitter
- p.His313= Single submitter
- p.Leu317Val Single submitter
- p.Val221Leu Single submitter
Uncertain significance 65
- p.Ala244Thr Single submitter ⚠
- p.Ala270Thr Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala356Val Single submitter ⚠
- p.Arg157Trp Single submitter
- p.Arg158Lys Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg161Ser Single submitter ⚠
- p.Arg254Cys Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg47Gln Single submitter ⚠
- p.Asn287Tyr Single submitter ⚠
- p.Asn366Lys Single submitter ⚠
- p.Asp169Asn Single submitter ⚠
- p.Asp226Val Single submitter ⚠
- p.Gln188Arg Single submitter ⚠
- p.Glu103Asp Single submitter ⚠
- p.Glu120Lys Single submitter ⚠
- p.Glu171Val Single submitter ⚠
- p.Glu180Ala Single submitter ⚠
- p.Glu180Asp Single submitter ⚠
- p.Gly102Ala Single submitter
- p.Gly109Arg Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly249Ala Single submitter ⚠
- p.Gly314Ser Single submitter ⚠
- p.Gly34Asp Single submitter ⚠
- p.Gly91Val Single submitter ⚠
- p.His220Arg Single submitter ⚠
- p.His264Gln Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Leu25Ile Single submitter ⚠
- p.Leu382Val Single submitter ⚠
- p.Leu7Arg Single submitter ⚠
- p.Met15Ile Single submitter ⚠
- p.Met15Leu Single submitter ⚠
- p.Met15Val Single submitter ⚠
- p.Met283Ile Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro215Leu Single submitter ⚠
- p.Pro247Thr Single submitter ⚠
- p.Pro256Ala Single submitter ⚠
- p.Ser131Leu Single submitter
- p.Ser194Thr Single submitter ⚠
- p.Ser27Arg Single submitter ⚠
- p.Ser339Leu Single submitter ⚠
- p.Ser339Trp Single submitter ⚠
- p.Ser353Leu Single submitter ⚠
- p.Thr63Ile Single submitter ⚠
- p.Trp140Gly Single submitter ⚠
- p.Trp160Cys Single submitter ⚠
- p.Trp185Cys Single submitter ⚠
- p.Trp282Cys Single submitter ⚠
- p.Tyr117His Single submitter ⚠
- p.Tyr92Cys Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val126Ile Single submitter ⚠
- p.Val17Met Single submitter ⚠
- p.Val184Met Single submitter ⚠
- p.Val289Met Single submitter ⚠
- p.Val29Ile Single submitter ⚠
- p.Val307Leu Single submitter ⚠
- p.Val323Met Single submitter ⚠