DNTTIP1 — 30 ClinVar variants
All ClinVar germline DNTTIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full DNTTIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DNTTIP1 p.Ala7Thr Uncertain significance Single submitter
- DNTTIP1 p.Arg138Gly Uncertain significance Single submitter
- DNTTIP1 p.Arg150Leu Uncertain significance Single submitter
- DNTTIP1 p.Arg180Gln Uncertain significance Single submitter
- DNTTIP1 p.Arg196His Uncertain significance Single submitter
- DNTTIP1 p.Arg321Cys Uncertain significance Single submitter
- DNTTIP1 p.Asn103Asp Uncertain significance Single submitter
- DNTTIP1 p.Asn87Lys Uncertain significance Single submitter
- DNTTIP1 p.Asp288Glu Uncertain significance Single submitter
- DNTTIP1 p.Asp6Gly Uncertain significance Single submitter
- DNTTIP1 p.Gln9Pro Uncertain significance Single submitter
- DNTTIP1 p.Glu142Asp Uncertain significance Single submitter
- DNTTIP1 p.Glu80Gln Uncertain significance Single submitter
- DNTTIP1 p.Glu80Lys Uncertain significance Single submitter
- DNTTIP1 p.Gly184Ser Uncertain significance Single submitter
- DNTTIP1 p.Gly20Val Uncertain significance Single submitter
- DNTTIP1 p.His158Pro Uncertain significance Single submitter
- DNTTIP1 p.His320Leu Uncertain significance Single submitter
- DNTTIP1 p.Leu176Pro Uncertain significance Single submitter
- DNTTIP1 p.Thr329Asn Uncertain significance Single submitter
- DNTTIP1 p.Thr4Ile Uncertain significance Single submitter
- DNTTIP1 p.Thr4Ser Uncertain significance Single submitter
- DNTTIP1 p.Val135Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DNTTIP1 p.Ala96Gly Uncertain significance Single submitter
- DNTTIP1 p.Ala96Thr Uncertain significance Single submitter
- DNTTIP1 p.Ala97Thr Uncertain significance Single submitter
- DNTTIP1 p.Phe60Leu Uncertain significance Single submitter
- DNTTIP1 p.Pro200Ala Uncertain significance Single submitter
- DNTTIP1 p.Pro204Ser Uncertain significance Single submitter
All DNTTIP1 variants
Likely benign 1
- p.Ala110Thr Single submitter
Uncertain significance 29
- p.Ala7Thr Single submitter ⚠
- p.Ala96Gly Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg138Gly Single submitter ⚠
- p.Arg150Leu Single submitter ⚠
- p.Arg180Gln Single submitter ⚠
- p.Arg196His Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Asn103Asp Single submitter ⚠
- p.Asn87Lys Single submitter ⚠
- p.Asp288Glu Single submitter ⚠
- p.Asp6Gly Single submitter ⚠
- p.Gln9Pro Single submitter ⚠
- p.Glu142Asp Single submitter ⚠
- p.Glu80Gln Single submitter ⚠
- p.Glu80Lys Single submitter ⚠
- p.Gly184Ser Single submitter ⚠
- p.Gly20Val Single submitter ⚠
- p.His158Pro Single submitter ⚠
- p.His320Leu Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Phe60Leu Single submitter ⚠
- p.Pro200Ala Single submitter ⚠
- p.Pro204Ser Single submitter ⚠
- p.Thr329Asn Single submitter ⚠
- p.Thr4Ile Single submitter ⚠
- p.Thr4Ser Single submitter ⚠
- p.Val135Leu Single submitter ⚠