DOCK4 — 315 ClinVar variants
All ClinVar germline DOCK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 264 flagged for review →
3 Likely pathogenic · 1 Conflicting · 13 Benign · 4 Benign/Likely benign · 32 Likely benign · 262 Uncertain significance
Full DOCK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 264
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 151
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 151
- DOCK4 p.Gln1223Arg Uncertain significance Multiple submitters
- DOCK4 p.Ala1309Gly Uncertain significance Single submitter
- DOCK4 p.Ala1481Gly Uncertain significance Single submitter
- DOCK4 p.Ala1694Val Uncertain significance Single submitter
- DOCK4 p.Ala1821Val Uncertain significance Single submitter
- DOCK4 p.Ala1956Ser Uncertain significance Single submitter
- DOCK4 p.Arg1041Trp Uncertain significance Single submitter
- DOCK4 p.Arg1150Gln Uncertain significance Single submitter
- DOCK4 p.Arg1210Cys Uncertain significance Single submitter
- DOCK4 p.Arg1244Gln Uncertain significance Single submitter
- DOCK4 p.Arg1260Cys Uncertain significance Single submitter
- DOCK4 p.Arg127Gln Uncertain significance Single submitter
- DOCK4 p.Arg127Trp Uncertain significance Single submitter
- DOCK4 p.Arg1299Lys Uncertain significance Single submitter
-
DOCK4 p.Arg1347Gln
Uncertain significance
Single submitter
neurodevelopmental disorder
-
DOCK4 p.Arg1429Gln
Uncertain significance
Single submitter
DOCK4-related disorder
- DOCK4 p.Arg1618His Uncertain significance Single submitter
- DOCK4 p.Arg1639His Uncertain significance Single submitter
- DOCK4 p.Arg1720Leu Uncertain significance Single submitter
- DOCK4 p.Arg182Gln Uncertain significance Single submitter
- DOCK4 p.Arg1903Leu Uncertain significance Single submitter
- DOCK4 p.Arg1921His Uncertain significance Single submitter
- DOCK4 p.Arg1958Lys Uncertain significance Single submitter
- DOCK4 p.Arg1970Cys Uncertain significance Single submitter
- DOCK4 p.Arg255Gln Uncertain significance Single submitter
- DOCK4 p.Arg541His Uncertain significance Single submitter
- DOCK4 p.Arg688Gln Uncertain significance Single submitter
- DOCK4 p.Arg694Gln Uncertain significance Single submitter
- DOCK4 p.Arg694Leu Uncertain significance Single submitter
- DOCK4 p.Arg781Gln Uncertain significance Single submitter
- DOCK4 p.Arg888Lys Uncertain significance Single submitter
- DOCK4 p.Arg924Gln Uncertain significance Single submitter
- DOCK4 p.Arg956Gln Uncertain significance Single submitter
- DOCK4 p.Asn1102Ser Uncertain significance Single submitter
- DOCK4 p.Asn154Ser Uncertain significance Single submitter
- DOCK4 p.Asn1848Asp Uncertain significance Single submitter
- DOCK4 p.Asn1848Ser Uncertain significance Single submitter
- DOCK4 p.Asn50Tyr Uncertain significance Single submitter
- DOCK4 p.Asn823Asp Uncertain significance Single submitter
- DOCK4 p.Asp1273Val Uncertain significance Single submitter
- DOCK4 p.Asp1631Tyr Uncertain significance Single submitter
- DOCK4 p.Asp262Gly Uncertain significance Single submitter
- DOCK4 p.Asp318Gly Uncertain significance Single submitter
- DOCK4 p.Asp367Val Uncertain significance Single submitter
- DOCK4 p.Asp779Gly Uncertain significance Single submitter
- DOCK4 p.Asp910Glu Uncertain significance Single submitter
- DOCK4 p.Cys293Tyr Uncertain significance Single submitter
- DOCK4 p.Cys574Arg Uncertain significance Single submitter
- DOCK4 p.Gln1291His Uncertain significance Single submitter
- DOCK4 p.Gln1576Glu Uncertain significance Single submitter
- DOCK4 p.Gln1606Arg Uncertain significance Single submitter
- DOCK4 p.Glu1293Asp Uncertain significance Single submitter
- DOCK4 p.Glu1474Gly Uncertain significance Single submitter
- DOCK4 p.Glu1729Asp Uncertain significance Single submitter
- DOCK4 p.Glu1729Gly Uncertain significance Single submitter
- DOCK4 p.Glu1784Gln Uncertain significance Single submitter
- DOCK4 p.Glu338Ala Uncertain significance Single submitter
- DOCK4 p.Glu425Asp Uncertain significance Single submitter
- DOCK4 p.Glu730Asp Uncertain significance Single submitter
- DOCK4 p.Glu749Asp Uncertain significance Single submitter
- DOCK4 p.Gly1068Asp Uncertain significance Single submitter
- DOCK4 p.Gly1754Arg Uncertain significance Single submitter
- DOCK4 p.Gly1792Arg Uncertain significance Single submitter
- DOCK4 p.Gly1822Arg Uncertain significance Single submitter
- DOCK4 p.Gly1854Ser Uncertain significance Single submitter
- DOCK4 p.Gly366Arg Uncertain significance Single submitter
- DOCK4 p.His1716Tyr Uncertain significance Single submitter
- DOCK4 p.His1750Leu Uncertain significance Single submitter
- DOCK4 p.His186Arg Uncertain significance Single submitter
- DOCK4 p.Ile1048Met Uncertain significance Single submitter
- DOCK4 p.Ile1381Thr Uncertain significance Single submitter
- DOCK4 p.Ile14Thr Uncertain significance Single submitter
- DOCK4 p.Ile1549Met Uncertain significance Single submitter
- DOCK4 p.Ile1636Met Uncertain significance Single submitter
- DOCK4 p.Ile341Val Uncertain significance Single submitter
- DOCK4 p.Ile406Val Uncertain significance Single submitter
- DOCK4 p.Ile951Val Uncertain significance Single submitter
- DOCK4 p.Ile979Val Uncertain significance Single submitter
- DOCK4 p.Leu1075Phe Uncertain significance Single submitter
- DOCK4 p.Leu1311Phe Uncertain significance Single submitter
- DOCK4 p.Leu1919Pro Uncertain significance Single submitter
- DOCK4 p.Leu1925Ile Uncertain significance Single submitter
- DOCK4 p.Leu306Val Uncertain significance Single submitter
- DOCK4 p.Leu702Pro Uncertain significance Single submitter
- DOCK4 p.Lys1059Arg Uncertain significance Single submitter
- DOCK4 p.Lys1204Asn Uncertain significance Single submitter
- DOCK4 p.Lys1314Arg Uncertain significance Single submitter
- DOCK4 p.Lys1414Arg Uncertain significance Single submitter
- DOCK4 p.Lys165Glu Uncertain significance Single submitter
- DOCK4 p.Lys1904Arg Uncertain significance Single submitter
- DOCK4 p.Lys863Glu Uncertain significance Single submitter
- DOCK4 p.Met1307Val Uncertain significance Single submitter
- DOCK4 p.Met1316Leu Uncertain significance Single submitter
- DOCK4 p.Met560Val Uncertain significance Single submitter
- DOCK4 p.Phe1062Ile Uncertain significance Single submitter
- DOCK4 p.Phe1335Ile Uncertain significance Single submitter
- DOCK4 p.Phe413Tyr Uncertain significance Single submitter
- DOCK4 p.Phe994Leu Uncertain significance Single submitter
- DOCK4 p.Pro1064Arg Uncertain significance Single submitter
- DOCK4 p.Pro1323Ala Uncertain significance Single submitter
- DOCK4 p.Pro1580Leu Uncertain significance Single submitter
- DOCK4 p.Pro1681Ser Uncertain significance Single submitter
- DOCK4 p.Pro1683Leu Uncertain significance Single submitter
- DOCK4 p.Pro1703Thr Uncertain significance Single submitter
- DOCK4 p.Pro1739Ala Uncertain significance Single submitter
- DOCK4 p.Pro1766Ser Uncertain significance Single submitter
- DOCK4 p.Pro1772Leu Uncertain significance Single submitter
- DOCK4 p.Pro1772Ser Uncertain significance Single submitter
- DOCK4 p.Pro1797Ser Uncertain significance Single submitter
-
DOCK4 p.Pro253Leu
Uncertain significance
Single submitter
neurodevelopmental disorder
- DOCK4 p.Pro449Ser Uncertain significance Single submitter
- DOCK4 p.Pro659His Uncertain significance Single submitter
- DOCK4 p.Pro832Thr Uncertain significance Single submitter
- DOCK4 p.Ser1100Asn Uncertain significance Single submitter
- DOCK4 p.Ser1119Thr Uncertain significance Single submitter
- DOCK4 p.Ser1415Asn Uncertain significance Single submitter
- DOCK4 p.Ser1444Gly Uncertain significance Single submitter
- DOCK4 p.Ser1462Cys Uncertain significance Single submitter
- DOCK4 p.Ser1595Asn Uncertain significance Single submitter
- DOCK4 p.Ser1789Leu Uncertain significance Single submitter
- DOCK4 p.Ser1836Pro Uncertain significance Single submitter
- DOCK4 p.Ser1950Arg Uncertain significance Single submitter
- DOCK4 p.Ser265Thr Uncertain significance Single submitter
- DOCK4 p.Ser443Ala Uncertain significance Single submitter
- DOCK4 p.Ser921Cys Uncertain significance Single submitter
- DOCK4 p.Thr1435Ile Uncertain significance Single submitter
- DOCK4 p.Thr1691Ala Uncertain significance Single submitter
- DOCK4 p.Thr1806Ser Uncertain significance Single submitter
- DOCK4 p.Thr1813Met Uncertain significance Single submitter
- DOCK4 p.Thr1868Ala Uncertain significance Single submitter
- DOCK4 p.Thr20Asn Uncertain significance Single submitter
- DOCK4 p.Thr592Ala Uncertain significance Single submitter
- DOCK4 p.Thr982Ala Uncertain significance Single submitter
- DOCK4 p.Tyr1198Cys Uncertain significance Single submitter
- DOCK4 p.Tyr1295His Uncertain significance Single submitter
- DOCK4 p.Tyr1840His Uncertain significance Single submitter
- DOCK4 p.Tyr1856Cys Uncertain significance Single submitter
-
DOCK4 p.Val1042Ala
Uncertain significance
Single submitter
neurodevelopmental disorder
- DOCK4 p.Val1591Leu Uncertain significance Single submitter
- DOCK4 p.Val1591Met Uncertain significance Single submitter
- DOCK4 p.Val162Met Uncertain significance Single submitter
- DOCK4 p.Val1663Ala Uncertain significance Single submitter
- DOCK4 p.Val1838Glu Uncertain significance Single submitter
- DOCK4 p.Val1933Ala Uncertain significance Single submitter
- DOCK4 p.Val1933Ile Uncertain significance Single submitter
- DOCK4 p.Val276Met Uncertain significance Single submitter
- DOCK4 p.Val62Ile Uncertain significance Single submitter
- DOCK4 p.Val660Ala Uncertain significance Single submitter
- DOCK4 p.Val69Ile Uncertain significance Single submitter
- DOCK4 p.Val974Leu Uncertain significance Single submitter
Predictors split 112
The independent predictors disagree with each other — read with care.
- DOCK4 p.Arg106Cys Likely benign Multiple submitters
- DOCK4 p.Arg490Trp Uncertain significance Multiple submitters
- DOCK4 p.Arg960Ser Benign/Likely benign Multiple submitters
- DOCK4 p.Pro1641Leu Uncertain significance Multiple submitters
- DOCK4 p.Pro1926Leu Likely benign Multiple submitters
- DOCK4 p.Ser750Arg Uncertain significance Multiple submitters
- DOCK4 p.Ala989Gly Uncertain significance Single submitter
- DOCK4 p.Arg114Trp Uncertain significance Single submitter
- DOCK4 p.Arg1286Gln Uncertain significance Single submitter
- DOCK4 p.Arg1470His Uncertain significance Single submitter
- DOCK4 p.Arg1551Gln Uncertain significance Single submitter
- DOCK4 p.Arg1730Lys Uncertain significance Single submitter
- DOCK4 p.Arg1921Leu Uncertain significance Single submitter
- DOCK4 p.Arg1957Trp Uncertain significance Single submitter
- DOCK4 p.Arg743Gly Uncertain significance Single submitter
- DOCK4 p.Arg743His Uncertain significance Single submitter
- DOCK4 p.Arg781Gly Uncertain significance Single submitter
- DOCK4 p.Asn1224Asp Uncertain significance Single submitter
- DOCK4 p.Asn1271Asp Uncertain significance Single submitter
- DOCK4 p.Asn1487His Uncertain significance Single submitter
- DOCK4 p.Asn823Lys Uncertain significance Single submitter
- DOCK4 p.Asp1080Gly Uncertain significance Single submitter
- DOCK4 p.Asp1217Gly Uncertain significance Single submitter
- DOCK4 p.Asp137Glu Uncertain significance Single submitter
- DOCK4 p.Asp251Ala Uncertain significance Single submitter
- DOCK4 p.Asp40Gly Uncertain significance Single submitter
- DOCK4 p.Asp595Gly Likely benign Single submitter
- DOCK4 p.Asp789Gly Likely benign Single submitter
- DOCK4 p.Cys211Tyr Uncertain significance Single submitter
- DOCK4 p.Gln102Leu Uncertain significance Single submitter
- DOCK4 p.Gln1503His Uncertain significance Single submitter
- DOCK4 p.Glu1237Lys Uncertain significance Single submitter
- DOCK4 p.Glu1355Gln Uncertain significance Single submitter
- DOCK4 p.Glu1385Gln Uncertain significance Single submitter
- DOCK4 p.Glu1486Asp Uncertain significance Single submitter
- DOCK4 p.Glu1571Ala Uncertain significance Single submitter
- DOCK4 p.Glu8Ala Uncertain significance Single submitter
- DOCK4 p.Gly550Val Uncertain significance Single submitter
- DOCK4 p.Ile1482Thr Uncertain significance Single submitter
- DOCK4 p.Ile385Leu Uncertain significance Single submitter
- DOCK4 p.Leu1034Phe Uncertain significance Single submitter
- DOCK4 p.Leu1160Phe Likely benign Single submitter
- DOCK4 p.Leu1284Phe Uncertain significance Single submitter
- DOCK4 p.Leu1452Val Uncertain significance Single submitter
- DOCK4 p.Leu157Val Uncertain significance Single submitter
- DOCK4 p.Leu202Val Uncertain significance Single submitter
- DOCK4 p.Leu363Ile Uncertain significance Single submitter
- DOCK4 p.Leu543Phe Uncertain significance Single submitter
- DOCK4 p.Leu944Gln Uncertain significance Single submitter
- DOCK4 p.Leu984Val Uncertain significance Single submitter
- DOCK4 p.Lys1030Asn Uncertain significance Single submitter
- DOCK4 p.Lys1032Thr Uncertain significance Single submitter
- DOCK4 p.Lys190Asn Uncertain significance Single submitter
-
DOCK4 p.Lys1971Asn
Uncertain significance
Single submitter
neurodevelopmental disorder
- DOCK4 p.Lys596Glu Uncertain significance Single submitter
- DOCK4 p.Met1371Leu Uncertain significance Single submitter
- DOCK4 p.Met1504Arg Uncertain significance Single submitter
- DOCK4 p.Phe1225Leu Uncertain significance Single submitter
- DOCK4 p.Phe567Leu Uncertain significance Single submitter
- DOCK4 p.Phe572Ser Uncertain significance Single submitter
- DOCK4 p.Pro1077Ala Uncertain significance Single submitter
- DOCK4 p.Pro1809Ser Uncertain significance Single submitter
- DOCK4 p.Pro1835Arg Uncertain significance Single submitter
-
DOCK4 p.Pro1835Leu
Uncertain significance
Single submitter
DOCK4-related disorder
- DOCK4 p.Pro1894Arg Likely benign Single submitter
- DOCK4 p.Pro1909Ala Uncertain significance Single submitter
- DOCK4 p.Pro1909Ser Uncertain significance Single submitter
- DOCK4 p.Pro1911Leu Uncertain significance Single submitter
- DOCK4 p.Pro1924Leu Uncertain significance Single submitter
- DOCK4 p.Pro1926His Uncertain significance Single submitter
- DOCK4 p.Pro1937Leu Uncertain significance Single submitter
- DOCK4 p.Pro1941Ala Uncertain significance Single submitter
- DOCK4 p.Pro1942Leu Uncertain significance Single submitter
- DOCK4 p.Pro509Leu Uncertain significance Single submitter
- DOCK4 p.Pro546His Uncertain significance Single submitter
-
DOCK4 p.Pro897Ser
Uncertain significance
Single submitter
autism spectrum disorder
- DOCK4 p.Pro961Leu Uncertain significance Single submitter
- DOCK4 p.Ser1028Tyr Likely benign Single submitter
- DOCK4 p.Ser1159Leu Uncertain significance Single submitter
- DOCK4 p.Ser16Cys Uncertain significance Single submitter
- DOCK4 p.Ser1817Tyr Uncertain significance Single submitter
- DOCK4 p.Ser1836Phe Uncertain significance Single submitter
- DOCK4 p.Ser1913Ile Uncertain significance Single submitter
- DOCK4 p.Ser1973Ala Uncertain significance Single submitter
- DOCK4 p.Ser566Phe Uncertain significance Single submitter
- DOCK4 p.Ser652Gly Uncertain significance Single submitter
- DOCK4 p.Ser803Tyr Uncertain significance Single submitter
- DOCK4 p.Ser856Thr Uncertain significance Single submitter
- DOCK4 p.Ser900Tyr Uncertain significance Single submitter
- DOCK4 p.Thr1256Ile Uncertain significance Single submitter
- DOCK4 p.Thr1868Lys Uncertain significance Single submitter
- DOCK4 p.Thr427Met Uncertain significance Single submitter
- DOCK4 p.Thr592Asn Uncertain significance Single submitter
-
DOCK4 p.Thr982Ile
Likely pathogenic
Single submitter
neurodevelopmental disorder
- DOCK4 p.Trp684Leu Uncertain significance Single submitter
- DOCK4 p.Tyr1216Cys Uncertain significance Single submitter
- DOCK4 p.Tyr1230Cys Uncertain significance Single submitter
- DOCK4 p.Tyr23Cys Uncertain significance Single submitter
- DOCK4 p.Tyr634Cys Uncertain significance Single submitter
- DOCK4 p.Val1586Phe Uncertain significance Single submitter
- DOCK4 p.Val1698Gly Uncertain significance Single submitter
- DOCK4 p.Val1891Leu Uncertain significance Single submitter
- DOCK4 p.Val1893Leu Uncertain significance Single submitter
- DOCK4 p.Val1893Met Likely benign Single submitter
- DOCK4 p.Val21Ile Benign Single submitter
- DOCK4 p.Val261Ala Uncertain significance Single submitter
-
DOCK4 p.Val420Met
Uncertain significance
Single submitter
neurodevelopmental disorder
- DOCK4 p.Val78Phe Uncertain significance Single submitter
- DOCK4 p.Val833Ala Uncertain significance Single submitter
- DOCK4 p.Val879Leu Uncertain significance Single submitter
-
DOCK4 p.Gly1038Ser
Uncertain significance
No assertion criteria
DOCK4-related disorder
-
DOCK4 p.Ser1913Asn
Likely benign
No assertion criteria
DOCK4-related disorder
All DOCK4 variants
Likely pathogenic 3
- p.Ile1067Thr Single submitter neurodevelopmental disorder
- p.Met1044Thr Single submitter neurodevelopmental disorder
- p.Thr982Ile Single submitter neurodevelopmental disorder ⚠
Conflicting classifications of pathogenicity 1
- p.Ser1476Thr Single submitter ⚠
Benign 13
- p.Asn1515= Multiple submitters
- p.Asp141= Multiple submitters
- p.Leu1264= Multiple submitters
- p.Leu361= Multiple submitters
- c.121+10C>G Single submitter
- c.2027+14T>A Single submitter
- c.784-7T>G Single submitter
- p.Arg1579Lys Single submitter
- p.Asn244= Single submitter
- p.Gln1831Lys Single submitter
- p.Pro1742Ala Single submitter
- p.Val21Ile Single submitter ⚠
- p.Ser1935Leu No assertion criteria DOCK4-related disorder
Benign/Likely benign 4
- c.550-8T>C Multiple submitters
- p.Arg106His Multiple submitters
- p.Arg960Ser Multiple submitters ⚠
- p.Lys472= Multiple submitters
Likely benign 32
- p.Arg106Cys Multiple submitters ⚠
- p.Asn535Asp Multiple submitters
- p.Gln1405= Multiple submitters
- p.Leu1010= Multiple submitters
- p.Leu804= Multiple submitters
- p.Pro1926Leu Multiple submitters ⚠
- c.1843-8T>C Single submitter
- c.2028-9G>A Single submitter
- c.3401+7A>G Single submitter
- c.3586-5dup Single submitter
- p.Arg1210= Single submitter
- p.Arg905Gln Single submitter
- p.Asp192= Single submitter
- p.Asp595Gly Single submitter ⚠
- p.Asp789Gly Single submitter ⚠
- p.Gln1358= Single submitter
- p.Gly1056Glu Single submitter
- p.His365= Single submitter
- p.Ile875= Single submitter
- p.Ile979= Single submitter
- p.Leu1160Phe Single submitter ⚠
- p.Leu1725= Single submitter
- p.Pro1886= Single submitter
- p.Pro1894Arg Single submitter ⚠
- p.Pro1938= Single submitter
- p.Ser1028Tyr Single submitter ⚠
- p.Ser1743Leu Single submitter
- p.Ser234= Single submitter
- p.Thr20= Single submitter
- p.Val1893Met Single submitter ⚠
- p.Ser1913Asn No assertion criteria DOCK4-related disorder ⚠
- p.Thr1806= No assertion criteria DOCK4-related disorder
Uncertain significance 262
- p.Arg490Trp Multiple submitters ⚠
- p.Gln1223Arg Multiple submitters ⚠
- p.Pro1641Leu Multiple submitters ⚠
- p.Ser750Arg Multiple submitters ⚠
- c.1192+9C>G Single submitter DOCK4-related disorder
- c.550-1G>T Single submitter
- p.Ala1309Gly Single submitter ⚠
- p.Ala1481Gly Single submitter ⚠
- p.Ala1694Val Single submitter ⚠
- p.Ala1821Val Single submitter ⚠
- p.Ala1956Ser Single submitter ⚠
- p.Ala989Gly Single submitter ⚠
- p.Arg1041Trp Single submitter ⚠
- p.Arg114Trp Single submitter ⚠
- p.Arg1150Gln Single submitter ⚠
- p.Arg1210Cys Single submitter ⚠
- p.Arg1244Gln Single submitter ⚠
- p.Arg1260Cys Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg1286Gln Single submitter ⚠
- p.Arg1299Lys Single submitter ⚠
- p.Arg1347Gln Single submitter neurodevelopmental disorder ⚠
- p.Arg1429Gln Single submitter DOCK4-related disorder ⚠
- p.Arg1470His Single submitter ⚠
- p.Arg1551Gln Single submitter ⚠
- p.Arg1618His Single submitter ⚠
- p.Arg1639His Single submitter ⚠
- p.Arg1720Leu Single submitter ⚠
- p.Arg1730Lys Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg1903Leu Single submitter ⚠
- p.Arg1921His Single submitter ⚠
- p.Arg1921Leu Single submitter ⚠
- p.Arg1957Trp Single submitter ⚠
- p.Arg1958Lys Single submitter ⚠
- p.Arg1970Cys Single submitter ⚠
- p.Arg255Gln Single submitter ⚠
- p.Arg283Ter Single submitter DOCK4-related disorder
- p.Arg298Ter Single submitter neurodevelopmental disorder
- p.Arg541His Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Arg694Gln Single submitter ⚠
- p.Arg694Leu Single submitter ⚠
- p.Arg743Gly Single submitter ⚠
- p.Arg743His Single submitter ⚠
- p.Arg781Gln Single submitter ⚠
- p.Arg781Gly Single submitter ⚠
- p.Arg888Lys Single submitter ⚠
- p.Arg924Gln Single submitter ⚠
- p.Arg924Ter Single submitter neurodevelopmental disorder
- p.Arg956Gln Single submitter ⚠
- p.Asn1102Ser Single submitter ⚠
- p.Asn1224Asp Single submitter ⚠
- p.Asn1271Asp Single submitter ⚠
- p.Asn1487His Single submitter ⚠
- p.Asn154Ser Single submitter ⚠
- p.Asn1848Asp Single submitter ⚠
- p.Asn1848Ser Single submitter ⚠
- p.Asn50Tyr Single submitter ⚠
- p.Asn823Asp Single submitter ⚠
- p.Asn823Lys Single submitter ⚠
- p.Asp1080Gly Single submitter ⚠
- p.Asp1217Gly Single submitter ⚠
- p.Asp1273Val Single submitter ⚠
- p.Asp1313fs Single submitter neurodevelopmental disorder
- p.Asp137Glu Single submitter ⚠
- p.Asp1631Tyr Single submitter ⚠
- p.Asp251Ala Single submitter ⚠
- p.Asp262Gly Single submitter ⚠
- p.Asp318Gly Single submitter ⚠
- p.Asp367Val Single submitter ⚠
- p.Asp40Gly Single submitter ⚠
- p.Asp779Gly Single submitter ⚠
- p.Asp910Glu Single submitter ⚠
- p.Cys211Tyr Single submitter ⚠
- p.Cys293Tyr Single submitter ⚠
- p.Cys574Arg Single submitter ⚠
- p.Gln102Leu Single submitter ⚠
- p.Gln1291His Single submitter ⚠
- p.Gln1503His Single submitter ⚠
- p.Gln1576Glu Single submitter ⚠
- p.Gln1606Arg Single submitter ⚠
- p.Glu1237Lys Single submitter ⚠
- p.Glu1293Asp Single submitter ⚠
- p.Glu1355Gln Single submitter ⚠
- p.Glu1385Gln Single submitter ⚠
- p.Glu1474Gly Single submitter ⚠
- p.Glu1486Asp Single submitter ⚠
- p.Glu1571Ala Single submitter ⚠
- p.Glu1729Asp Single submitter ⚠
- p.Glu1729Gly Single submitter ⚠
- p.Glu1784Gln Single submitter ⚠
- p.Glu338Ala Single submitter ⚠
- p.Glu425Asp Single submitter ⚠
- p.Glu730Asp Single submitter ⚠
- p.Glu749Asp Single submitter ⚠
- p.Glu8Ala Single submitter ⚠
- p.Glu914fs Single submitter DOCK4-related disorder
- p.Gly1068Asp Single submitter ⚠
- p.Gly1754Arg Single submitter ⚠
- p.Gly1792Arg Single submitter ⚠
- p.Gly1822Arg Single submitter ⚠
- p.Gly1854Ser Single submitter ⚠
- p.Gly366Arg Single submitter ⚠
- p.Gly550Val Single submitter ⚠
- p.His1716Tyr Single submitter ⚠
- p.His1750Leu Single submitter ⚠
- p.His186Arg Single submitter ⚠
- p.Ile1048Met Single submitter ⚠
- p.Ile1381Thr Single submitter ⚠
- p.Ile1482Thr Single submitter ⚠
- p.Ile14Thr Single submitter ⚠
- p.Ile1549Met Single submitter ⚠
- p.Ile1636Met Single submitter ⚠
- p.Ile341Val Single submitter ⚠
- p.Ile385Leu Single submitter ⚠
- p.Ile406Val Single submitter ⚠
- p.Ile951Val Single submitter ⚠
- p.Ile979Val Single submitter ⚠
- p.Leu1034Phe Single submitter ⚠
- p.Leu1075Phe Single submitter ⚠
- p.Leu1284Phe Single submitter ⚠
- p.Leu1311Phe Single submitter ⚠
- p.Leu1452Val Single submitter ⚠
- p.Leu157Val Single submitter ⚠
- p.Leu1919Pro Single submitter ⚠
- p.Leu1925Ile Single submitter ⚠
- p.Leu202Val Single submitter ⚠
- p.Leu306Val Single submitter ⚠
- p.Leu363Ile Single submitter ⚠
- p.Leu543Phe Single submitter ⚠
- p.Leu702Pro Single submitter ⚠
- p.Leu944Gln Single submitter ⚠
- p.Leu984Val Single submitter ⚠
- p.Lys1030Asn Single submitter ⚠
- p.Lys1032Thr Single submitter ⚠
- p.Lys1059Arg Single submitter ⚠
- p.Lys1204Asn Single submitter ⚠
- p.Lys1314Arg Single submitter ⚠
- p.Lys1414Arg Single submitter ⚠
- p.Lys165Glu Single submitter ⚠
- p.Lys1904Arg Single submitter ⚠
- p.Lys190Asn Single submitter ⚠
- p.Lys1971Asn Single submitter neurodevelopmental disorder ⚠
- p.Lys596Glu Single submitter ⚠
- p.Lys863Glu Single submitter ⚠
- p.Met1307Val Single submitter ⚠
- p.Met1316Leu Single submitter ⚠
- p.Met1371Leu Single submitter ⚠
- p.Met1504Arg Single submitter ⚠
- p.Met560Val Single submitter ⚠
- p.Phe1062Ile Single submitter ⚠
- p.Phe1225Leu Single submitter ⚠
- p.Phe1335Ile Single submitter ⚠
- p.Phe413Tyr Single submitter ⚠
- p.Phe567Leu Single submitter ⚠
- p.Phe572Ser Single submitter ⚠
- p.Phe994Leu Single submitter ⚠
- p.Pro1064Arg Single submitter ⚠
- p.Pro1077Ala Single submitter ⚠
- p.Pro1323Ala Single submitter ⚠
- p.Pro1580Leu Single submitter ⚠
- p.Pro1681Ser Single submitter ⚠
- p.Pro1683Leu Single submitter ⚠
- p.Pro1703Thr Single submitter ⚠
- p.Pro1739Ala Single submitter ⚠
- p.Pro1766Ser Single submitter ⚠
- p.Pro1772Leu Single submitter ⚠
- p.Pro1772Ser Single submitter ⚠
- p.Pro1797Ser Single submitter ⚠
- p.Pro1809Ser Single submitter ⚠
- p.Pro1835Arg Single submitter ⚠
- p.Pro1835Leu Single submitter DOCK4-related disorder ⚠
- p.Pro1909Ala Single submitter ⚠
- p.Pro1909Ser Single submitter ⚠
- p.Pro1911Leu Single submitter ⚠
- p.Pro1924Leu Single submitter ⚠
- p.Pro1926His Single submitter ⚠
- p.Pro1937Leu Single submitter ⚠
- p.Pro1941Ala Single submitter ⚠
- p.Pro1942Leu Single submitter ⚠
- p.Pro253Leu Single submitter neurodevelopmental disorder ⚠
- p.Pro449Ser Single submitter ⚠
- p.Pro509Leu Single submitter ⚠
- p.Pro546His Single submitter ⚠
- p.Pro659His Single submitter ⚠
- p.Pro832Thr Single submitter ⚠
- p.Pro897Ser Single submitter autism spectrum disorder ⚠
- p.Pro961Leu Single submitter ⚠
- p.Ser1100Asn Single submitter ⚠
- p.Ser1119Thr Single submitter ⚠
- p.Ser1159Leu Single submitter ⚠
- p.Ser1415Asn Single submitter ⚠
- p.Ser1444Gly Single submitter ⚠
- p.Ser1462Cys Single submitter ⚠
- p.Ser1595Asn Single submitter ⚠
- p.Ser16Cys Single submitter ⚠
- p.Ser1789Leu Single submitter ⚠
- p.Ser1817Tyr Single submitter ⚠
- p.Ser1836Phe Single submitter ⚠
- p.Ser1836Pro Single submitter ⚠
- p.Ser1913Ile Single submitter ⚠
- p.Ser1950Arg Single submitter ⚠
- p.Ser1973Ala Single submitter ⚠
- p.Ser265Thr Single submitter ⚠
- p.Ser443Ala Single submitter ⚠
- p.Ser566Phe Single submitter ⚠
- p.Ser652Gly Single submitter ⚠
- p.Ser803Tyr Single submitter ⚠
- p.Ser856Thr Single submitter ⚠
- p.Ser900Tyr Single submitter ⚠
- p.Ser921Cys Single submitter ⚠
- p.Thr1256Ile Single submitter ⚠
- p.Thr1435Ile Single submitter ⚠
- p.Thr1691Ala Single submitter ⚠
- p.Thr1806Ser Single submitter ⚠
- p.Thr1813Met Single submitter ⚠
- p.Thr1868Ala Single submitter ⚠
- p.Thr1868Lys Single submitter ⚠
- p.Thr20Asn Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr592Ala Single submitter ⚠
- p.Thr592Asn Single submitter ⚠
- p.Thr982Ala Single submitter ⚠
- p.Trp1464Ter Single submitter neurodevelopmental disorder
- p.Trp684Leu Single submitter ⚠
- p.Tyr1198Cys Single submitter ⚠
- p.Tyr1216Cys Single submitter ⚠
- p.Tyr1230Cys Single submitter ⚠
- p.Tyr1295His Single submitter ⚠
- p.Tyr1840His Single submitter ⚠
- p.Tyr1856Cys Single submitter ⚠
- p.Tyr23Cys Single submitter ⚠
- p.Tyr634Cys Single submitter ⚠
- p.Val1042Ala Single submitter neurodevelopmental disorder ⚠
- p.Val1586Phe Single submitter ⚠
- p.Val1591Leu Single submitter ⚠
- p.Val1591Met Single submitter ⚠
- p.Val162Met Single submitter ⚠
- p.Val1663Ala Single submitter ⚠
- p.Val1698Gly Single submitter ⚠
- p.Val1838Glu Single submitter ⚠
- p.Val1891Leu Single submitter ⚠
- p.Val1893Leu Single submitter ⚠
- p.Val1933Ala Single submitter ⚠
- p.Val1933Ile Single submitter ⚠
- p.Val261Ala Single submitter ⚠
- p.Val276Met Single submitter ⚠
- p.Val420Met Single submitter neurodevelopmental disorder ⚠
- p.Val62Ile Single submitter ⚠
- p.Val660Ala Single submitter ⚠
- p.Val69Ile Single submitter ⚠
- p.Val78Phe Single submitter ⚠
- p.Val833Ala Single submitter ⚠
- p.Val879Leu Single submitter ⚠
- p.Val974Leu Single submitter ⚠
- c.3316-10T>G No assertion criteria DOCK4-related disorder
- c.4417-2A>G No assertion criteria DOCK4-related disorder
- p.Gln1498Ter No assertion criteria DOCK4-related disorder
- p.Gly1038Ser No assertion criteria DOCK4-related disorder ⚠
- p.Pro1800Ser No assertion criteria DOCK4-related disorder ⚠