DOCK5 — 295 ClinVar variants

All ClinVar germline DOCK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 276 flagged for review →

5 Benign · 2 Benign/Likely benign · 14 Likely benign · 274 Uncertain significance

Full DOCK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 276

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 137

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 139

The independent predictors disagree with each other — read with care.

All DOCK5 variants

Benign 5

c.4788+9C>T Multiple submitters
p.Met987Leu Multiple submitters
p.Pro1467= Multiple submitters
p.Ser1306= Multiple submitters
c.1192+7_1192+37del Single submitter

Benign/Likely benign 2

p.Leu986Phe Multiple submitters
p.Thr469Met Multiple submitters ⚠

Likely benign 14

p.Ala1558= Single submitter
p.Ala696= Single submitter
p.Glu188= Single submitter
p.Ile1672Val Single submitter
p.Ile181Val Single submitter
p.Ile373Thr Single submitter
p.Leu1774= Single submitter
p.Met1770Val Single submitter
p.Phe1308= Single submitter
p.Phe551= Single submitter
p.Thr1063Ile Single submitter ⚠
p.Tyr246= Single submitter
p.Val189Met Single submitter
p.Val294Ile Single submitter

Uncertain significance 274

p.Ala1067Val Single submitter ⚠
p.Ala1194Ser Single submitter ⚠
p.Ala1346Ser Single submitter ⚠
p.Ala1405Val Single submitter ⚠
p.Ala15Val Single submitter ⚠
p.Ala1812Thr Single submitter ⚠
p.Ala1812Val Single submitter ⚠
p.Ala182Pro Single submitter ⚠
p.Ala1857Val Single submitter ⚠
p.Ala582Thr Single submitter ⚠
p.Ala744Ser Single submitter ⚠
p.Ala797Val Single submitter ⚠
p.Ala959Ser Single submitter ⚠
p.Arg1015Ser Single submitter ⚠
p.Arg1019His Single submitter ⚠
p.Arg1069Cys Single submitter ⚠
p.Arg1088Gln Single submitter ⚠
p.Arg1121Gln Single submitter ⚠
p.Arg1121Trp Single submitter ⚠
p.Arg128Trp Single submitter ⚠
p.Arg1384Trp Single submitter ⚠
p.Arg1390Trp Single submitter ⚠
p.Arg1466Trp Single submitter ⚠
p.Arg1469Gln Single submitter ⚠
p.Arg1469Trp Single submitter ⚠
p.Arg1486Gln Single submitter ⚠
p.Arg1540Pro Single submitter ⚠
p.Arg1540Trp Single submitter ⚠
p.Arg1668Gln Single submitter ⚠
p.Arg166Gln Single submitter ⚠
p.Arg1707His Single submitter ⚠
p.Arg1773Gln Single submitter ⚠
p.Arg1832Lys Single submitter ⚠
p.Arg1858Gln Single submitter ⚠
p.Arg1858Trp Single submitter ⚠
p.Arg211Gln Single submitter ⚠
p.Arg211Trp Single submitter ⚠
p.Arg293Cys Single submitter ⚠
p.Arg358Cys Single submitter ⚠
p.Arg429Trp Single submitter ⚠
p.Arg443Gln Single submitter ⚠
p.Arg524Gly Single submitter ⚠
p.Arg532Gln Single submitter ⚠
p.Arg792Cys Single submitter ⚠
p.Arg854Gln Single submitter ⚠
p.Arg870Leu Single submitter ⚠
p.Arg931Trp Single submitter ⚠
p.Arg945Gln Single submitter ⚠
p.Asn1010Ser Single submitter ⚠
p.Asn1137Ser Single submitter ⚠
p.Asn1340His Single submitter ⚠
p.Asn156His Single submitter ⚠
p.Asn20Ser Single submitter ⚠
p.Asn275Ser Single submitter ⚠
p.Asn384Lys Single submitter ⚠
p.Asn416Asp Single submitter ⚠
p.Asn649Ser Single submitter ⚠
p.Asn713Ser Single submitter ⚠
p.Asn858Tyr Single submitter ⚠
p.Asp1309Asn Single submitter ⚠
p.Asp1417Asn Single submitter ⚠
p.Asp1417Gly Single submitter ⚠
p.Asp153Glu Single submitter ⚠
p.Asp1582His Single submitter ⚠
p.Asp162Gly Single submitter ⚠
p.Asp174Glu Single submitter ⚠
p.Asp247Asn Single submitter ⚠
p.Asp283Glu Single submitter ⚠
p.Asp331Val Single submitter ⚠
p.Asp339Asn Single submitter ⚠
p.Asp474Asn Single submitter ⚠
p.Asp474Glu Single submitter ⚠
p.Asp558Gly Single submitter ⚠
p.Asp966Asn Single submitter ⚠
p.Asp981Asn Single submitter ⚠
p.Asp995Glu Single submitter ⚠
p.Cys1254Tyr Single submitter ⚠
p.Gln1060His Single submitter ⚠
p.Gln1167Pro Single submitter ⚠
p.Gln1213Arg Single submitter ⚠
p.Gln1424His Single submitter ⚠
p.Gln206Arg Single submitter ⚠
p.Gln213Arg Single submitter ⚠
p.Gln889Arg Single submitter ⚠
p.Gln926Arg Single submitter ⚠
p.Gln946Leu Single submitter ⚠
p.Gln980His Single submitter ⚠
p.Glu1173Gln Single submitter ⚠
p.Glu1255Lys Single submitter ⚠
p.Glu1329Lys Single submitter ⚠
p.Glu1472Lys Single submitter ⚠
p.Glu1527Lys Single submitter ⚠
p.Glu1578Gln Single submitter ⚠
p.Glu1584Asp Single submitter ⚠
p.Glu1584Lys Single submitter ⚠
p.Glu1634Gly Single submitter ⚠
p.Glu1706Asp Single submitter ⚠
p.Glu1846Gln Single submitter ⚠
p.Glu42Lys Single submitter ⚠
p.Glu491Lys Single submitter ⚠
p.Glu511Val Single submitter ⚠
p.Glu520Gly Single submitter ⚠
p.Glu596Gln Single submitter ⚠
p.Glu72Gly Single submitter ⚠
p.Glu835Gly Single submitter ⚠
p.Gly1095Ala Single submitter ⚠
p.Gly1142Asp Single submitter ⚠
p.Gly1366Arg Single submitter ⚠
p.Gly1779Ser Single submitter ⚠
p.Gly477Ser Single submitter ⚠
p.Gly489Glu Single submitter ⚠
p.Gly565Trp Single submitter ⚠
p.Gly57Ala Single submitter ⚠
p.His1251Tyr Single submitter ⚠
p.His1579Tyr Single submitter ⚠
p.His1778Pro Single submitter ⚠
p.His305Tyr Single submitter ⚠
p.His723Gln Single submitter ⚠
p.His949Arg Single submitter ⚠
p.His971Gln Single submitter ⚠
p.Ile101Val Single submitter ⚠
p.Ile1021Val Single submitter ⚠
p.Ile1305Met Single submitter ⚠
p.Ile1380Thr Single submitter ⚠
p.Ile152Thr Single submitter ⚠
p.Ile1657Val Single submitter ⚠
p.Ile16Val Single submitter ⚠
p.Ile235Leu Single submitter ⚠
p.Ile484Thr Single submitter ⚠
p.Ile484Val Single submitter ⚠
p.Ile517Thr Single submitter ⚠
p.Ile665Val Single submitter ⚠
p.Ile704Leu Single submitter ⚠
p.Ile704Val Single submitter ⚠
p.Ile768Phe Single submitter ⚠
p.Ile823Val Single submitter ⚠
p.Ile863Thr Single submitter ⚠
p.Leu1201Val Single submitter ⚠
p.Leu1399Phe Single submitter ⚠
p.Leu141Met Single submitter ⚠
p.Leu1667Val Single submitter ⚠
p.Leu1705Met Single submitter ⚠
p.Leu1720Phe Single submitter ⚠
p.Leu1837Val Single submitter ⚠
p.Leu406Phe Single submitter ⚠
p.Leu479Phe Single submitter ⚠
p.Lys1068Glu Single submitter ⚠
p.Lys110Arg Single submitter ⚠
p.Lys1184Arg Single submitter ⚠
p.Lys1319Gln Single submitter ⚠
p.Lys1322Arg Single submitter ⚠
p.Lys1331Gln Single submitter ⚠
p.Lys138Arg Single submitter ⚠
p.Lys1407Glu Single submitter ⚠
p.Lys1590Gln Single submitter ⚠
p.Lys1630Arg Single submitter ⚠
p.Lys185Arg Single submitter ⚠
p.Lys229Arg Single submitter ⚠
p.Lys482Arg Single submitter ⚠
p.Lys651Glu Single submitter ⚠
p.Lys708Asn Single submitter ⚠
p.Lys813Gln Single submitter ⚠
p.Lys828Arg Single submitter ⚠
p.Lys862Asn Single submitter ⚠
p.Lys994Glu Single submitter ⚠
p.Lys999Arg Single submitter ⚠
p.Met1033Thr Single submitter ⚠
p.Met1033Val Single submitter ⚠
p.Met1356Thr Single submitter ⚠
p.Met1356Val Single submitter ⚠
p.Met1426Val Single submitter ⚠
p.Met158Leu Single submitter ⚠
p.Met267Ile Single submitter ⚠
p.Met431Val Single submitter ⚠
p.Met593Ile Single submitter ⚠
p.Met595Ile Single submitter ⚠
p.Met680Thr Single submitter ⚠
p.Met681Leu Single submitter ⚠
p.Met681Val Single submitter ⚠
p.Met800Val Single submitter ⚠
p.Met802Thr Single submitter ⚠
p.Met992Thr Single submitter ⚠
p.Phe1047Leu Single submitter ⚠
p.Phe1402Leu Single submitter ⚠
p.Pro1096Ser Single submitter ⚠
p.Pro1280Leu Single submitter ⚠
p.Pro1413Ser Single submitter ⚠
p.Pro1439Arg Single submitter ⚠
p.Pro1439Leu Single submitter ⚠
p.Pro1580Ser Single submitter ⚠
p.Pro1617Leu Single submitter ⚠
p.Pro1660Arg Single submitter ⚠
p.Pro1694Arg Single submitter ⚠
p.Pro1694Leu Single submitter ⚠
p.Pro1750Ser Single submitter ⚠
p.Pro1817Thr Single submitter ⚠
p.Pro1821Ala Single submitter ⚠
p.Pro1822Ser Single submitter ⚠
p.Pro1852Ala Single submitter ⚠
p.Pro347Leu Single submitter ⚠
p.Pro434Ala Single submitter ⚠
p.Pro486Leu Single submitter ⚠
p.Pro557Leu Single submitter ⚠
p.Pro6Thr Single submitter ⚠
p.Pro805Thr Single submitter ⚠
p.Pro948Leu Single submitter ⚠
p.Ser1139Cys Single submitter ⚠
p.Ser1216Arg Single submitter ⚠
p.Ser1330Asn Single submitter ⚠
p.Ser1513Asn Single submitter ⚠
p.Ser1552Arg Single submitter ⚠
p.Ser1686Leu Single submitter ⚠
p.Ser1699Leu Single submitter ⚠
p.Ser1834Phe Single submitter ⚠
p.Ser217Gly Single submitter ⚠
p.Ser295Thr Single submitter ⚠
p.Ser603Thr Single submitter ⚠
p.Ser612Asn Single submitter ⚠
p.Ser702Leu Single submitter ⚠
p.Ser822Arg Single submitter ⚠
p.Ser866Arg Single submitter ⚠
p.Ser903Trp Single submitter ⚠
p.Ser93Cys Single submitter ⚠
p.Ser947Pro Single submitter ⚠
p.Thr1063Ala Single submitter ⚠
p.Thr121Met Single submitter ⚠
p.Thr1263Ala Single submitter ⚠
p.Thr1412Met Single submitter ⚠
p.Thr1488Met Single submitter ⚠
p.Thr1490Met Single submitter ⚠
p.Thr1601Arg Single submitter ⚠
p.Thr1654Met Single submitter ⚠
p.Thr1835Pro Single submitter ⚠
p.Thr221Ala Single submitter ⚠
p.Thr561Ala Single submitter ⚠
p.Thr587Asn Single submitter ⚠
p.Thr591Pro Single submitter ⚠
p.Thr610Ser Single submitter ⚠
p.Thr727Ile Single submitter ⚠
p.Thr7Ser Single submitter ⚠
p.Thr883Arg Single submitter ⚠
p.Thr883Ser Single submitter ⚠
p.Trp509Cys Single submitter ⚠
p.Tyr1185Ser Single submitter ⚠
p.Tyr1245Cys Single submitter ⚠
p.Tyr1335Ser Single submitter ⚠
p.Tyr1368Cys Single submitter ⚠
p.Tyr1388Asn Single submitter ⚠
p.Tyr1441Cys Single submitter ⚠
p.Tyr1454Cys Single submitter ⚠
p.Tyr1489Cys Single submitter ⚠
p.Tyr17Cys Single submitter ⚠
p.Tyr222Cys Single submitter ⚠
p.Tyr258Cys Single submitter ⚠
p.Tyr45His Single submitter ⚠
p.Tyr48Cys Single submitter ⚠
p.Tyr689Cys Single submitter ⚠
p.Tyr689His Single submitter ⚠
p.Tyr740Cys Single submitter ⚠
p.Tyr778Ser Single submitter ⚠
p.Val100Ile Single submitter ⚠
p.Val1227Leu Single submitter ⚠
p.Val1332Ala Single submitter ⚠
p.Val1533Ala Single submitter ⚠
p.Val1715Ile Single submitter ⚠
p.Val25Leu Single submitter ⚠
p.Val303Glu Single submitter ⚠
p.Val372Met Single submitter ⚠
p.Val421Ile Single submitter ⚠
p.Val552Met Single submitter ⚠
p.Val834Asp Single submitter ⚠
p.Val864Ala Single submitter ⚠
p.Val940Met Single submitter ⚠
p.Ala1709Ser No assertion criteria prostate cancer ⚠