DOK2 — 100 ClinVar variants
All ClinVar germline DOK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
2 Benign · 6 Likely benign · 92 Uncertain significance
Full DOK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK2 p.Ala28Pro Uncertain significance Single submitter
- DOK2 p.Ala372Val Uncertain significance Single submitter
- DOK2 p.Ala37Ser Uncertain significance Single submitter
- DOK2 p.Ala75Thr Uncertain significance Single submitter
- DOK2 p.Arg201Cys Uncertain significance Single submitter
- DOK2 p.Arg204Pro Uncertain significance Single submitter
- DOK2 p.Arg215Cys Uncertain significance Single submitter
- DOK2 p.Arg266Gln Uncertain significance Single submitter
- DOK2 p.Arg273Gln Uncertain significance Single submitter
- DOK2 p.Arg308Gly Uncertain significance Single submitter
- DOK2 p.Arg308His Uncertain significance Single submitter
- DOK2 p.Arg308Pro Uncertain significance Single submitter
- DOK2 p.Cys132Arg Uncertain significance Single submitter
- DOK2 p.Cys36Phe Uncertain significance Single submitter
- DOK2 p.Cys65Ser Uncertain significance Single submitter
- DOK2 p.Gln323Glu Uncertain significance Single submitter
- DOK2 p.Glu296Asp Uncertain significance Single submitter
- DOK2 p.Glu296Gly Uncertain significance Single submitter
- DOK2 p.Glu347Gly Uncertain significance Single submitter
- DOK2 p.Glu349Lys Uncertain significance Single submitter
- DOK2 p.Gly126Arg Uncertain significance Single submitter
- DOK2 p.Gly168Arg Uncertain significance Single submitter
- DOK2 p.Gly168Glu Uncertain significance Single submitter
- DOK2 p.Gly27Ser Uncertain significance Single submitter
- DOK2 p.Gly316Asp Uncertain significance Single submitter
- DOK2 p.Gly395Ser Uncertain significance Single submitter
- DOK2 p.Gly72Arg Uncertain significance Single submitter
- DOK2 p.His275Arg Uncertain significance Single submitter
- DOK2 p.Ile109Asn Uncertain significance Single submitter
- DOK2 p.Leu30Gln Uncertain significance Single submitter
- DOK2 p.Leu43Pro Uncertain significance Single submitter
- DOK2 p.Leu66Val Uncertain significance Single submitter
- DOK2 p.Leu86Pro Uncertain significance Single submitter
- DOK2 p.Lys7Glu Uncertain significance Single submitter
- DOK2 p.Lys89Arg Uncertain significance Single submitter
- DOK2 p.Phe209Ser Uncertain significance Single submitter
- DOK2 p.Phe211Val Uncertain significance Single submitter
- DOK2 p.Pro257Ala Uncertain significance Single submitter
- DOK2 p.Pro279Leu Uncertain significance Single submitter
- DOK2 p.Pro339Arg Uncertain significance Single submitter
- DOK2 p.Pro378Ala Uncertain significance Single submitter
- DOK2 p.Ser263Leu Uncertain significance Single submitter
- DOK2 p.Ser277Leu Uncertain significance Single submitter
- DOK2 p.Ser63Thr Uncertain significance Single submitter
- DOK2 p.Thr284Pro Uncertain significance Single submitter
- DOK2 p.Thr285Pro Uncertain significance Single submitter
- DOK2 p.Trp105Arg Uncertain significance Single submitter
- DOK2 p.Val153Met Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- DOK2 p.Ala113Thr Uncertain significance Single submitter
- DOK2 p.Ala160Thr Uncertain significance Single submitter
- DOK2 p.Ala237Val Uncertain significance Single submitter
- DOK2 p.Ala379Val Uncertain significance Single submitter
- DOK2 p.Ala37Thr Uncertain significance Single submitter
- DOK2 p.Arg102His Uncertain significance Single submitter
- DOK2 p.Arg130Trp Uncertain significance Single submitter
- DOK2 p.Arg173Gln Benign Single submitter
- DOK2 p.Arg273Trp Uncertain significance Single submitter
- DOK2 p.Arg308Cys Uncertain significance Single submitter
- DOK2 p.Arg308Leu Uncertain significance Single submitter
- DOK2 p.Arg369Lys Uncertain significance Single submitter
- DOK2 p.Arg51Cys Uncertain significance Single submitter
- DOK2 p.Arg57Trp Uncertain significance Single submitter
- DOK2 p.Arg67Leu Uncertain significance Single submitter
- DOK2 p.Asp358Glu Uncertain significance Single submitter
- DOK2 p.Asp358Gly Uncertain significance Single submitter
- DOK2 p.Asp390Tyr Uncertain significance Single submitter
- DOK2 p.Cys110Tyr Uncertain significance Single submitter
- DOK2 p.Glu101Val Uncertain significance Single submitter
- DOK2 p.Glu225Val Uncertain significance Single submitter
- DOK2 p.Gly175Arg Uncertain significance Single submitter
- DOK2 p.Gly27Asp Uncertain significance Single submitter
- DOK2 p.Leu13Phe Uncertain significance Single submitter
- DOK2 p.Leu356Phe Uncertain significance Single submitter
- DOK2 p.Leu92Pro Uncertain significance Single submitter
- DOK2 p.Met133Ile Uncertain significance Single submitter
- DOK2 p.Phe26Cys Uncertain significance Single submitter
- DOK2 p.Phe303Leu Uncertain significance Single submitter
- DOK2 p.Pro255Leu Uncertain significance Single submitter
- DOK2 p.Pro261Leu Uncertain significance Single submitter
- DOK2 p.Pro261Ser Uncertain significance Single submitter
- DOK2 p.Pro265Ser Uncertain significance Single submitter
- DOK2 p.Pro267Thr Uncertain significance Single submitter
- DOK2 p.Pro286Gln Uncertain significance Single submitter
- DOK2 p.Pro286Leu Likely benign Single submitter
- DOK2 p.Pro290Ser Uncertain significance Single submitter
- DOK2 p.Pro290Thr Uncertain significance Single submitter
- DOK2 p.Pro360Leu Likely benign Single submitter
- DOK2 p.Ser141Gly Uncertain significance Single submitter
- DOK2 p.Ser269Ile Uncertain significance Single submitter
- DOK2 p.Ser34Leu Uncertain significance Single submitter
- DOK2 p.Ser392Cys Uncertain significance Single submitter
- DOK2 p.Ser82Thr Uncertain significance Single submitter
- DOK2 p.Tyr345Cys Uncertain significance Single submitter
- DOK2 p.Tyr345His Uncertain significance Single submitter
- DOK2 p.Tyr93His Uncertain significance Single submitter
All DOK2 variants
Benign 2
- p.Ser394Ala Multiple submitters
- p.Arg173Gln Single submitter ⚠
Likely benign 6
- p.Ala99Thr Single submitter
- p.Arg364Gln Single submitter
- p.Gly103Ser Single submitter
- p.Ile260Val Single submitter
- p.Pro286Leu Single submitter ⚠
- p.Pro360Leu Single submitter ⚠
Uncertain significance 92
- p.Ala113Thr Single submitter ⚠
- p.Ala160Thr Single submitter ⚠
- p.Ala237Val Single submitter ⚠
- p.Ala28Pro Single submitter ⚠
- p.Ala372Val Single submitter ⚠
- p.Ala379Val Single submitter ⚠
- p.Ala37Ser Single submitter ⚠
- p.Ala37Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg201Cys Single submitter ⚠
- p.Arg204Pro Single submitter ⚠
- p.Arg215Cys Single submitter ⚠
- p.Arg266Gln Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg273Trp Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Arg308Gly Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg308Leu Single submitter ⚠
- p.Arg308Pro Single submitter ⚠
- p.Arg369Lys Single submitter ⚠
- p.Arg51Cys Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Arg67Leu Single submitter ⚠
- p.Asp358Glu Single submitter ⚠
- p.Asp358Gly Single submitter ⚠
- p.Asp390Tyr Single submitter ⚠
- p.Cys110Tyr Single submitter ⚠
- p.Cys132Arg Single submitter ⚠
- p.Cys36Phe Single submitter ⚠
- p.Cys65Ser Single submitter ⚠
- p.Gln323Glu Single submitter ⚠
- p.Glu101Val Single submitter ⚠
- p.Glu225Val Single submitter ⚠
- p.Glu296Asp Single submitter ⚠
- p.Glu296Gly Single submitter ⚠
- p.Glu347Gly Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly168Arg Single submitter ⚠
- p.Gly168Glu Single submitter ⚠
- p.Gly175Arg Single submitter ⚠
- p.Gly27Asp Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly316Asp Single submitter ⚠
- p.Gly395Ser Single submitter ⚠
- p.Gly72Arg Single submitter ⚠
- p.His275Arg Single submitter ⚠
- p.Ile109Asn Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu30Gln Single submitter ⚠
- p.Leu356Phe Single submitter ⚠
- p.Leu43Pro Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Leu86Pro Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Lys7Glu Single submitter ⚠
- p.Lys89Arg Single submitter ⚠
- p.Met133Ile Single submitter ⚠
- p.Phe209Ser Single submitter ⚠
- p.Phe211Val Single submitter ⚠
- p.Phe26Cys Single submitter ⚠
- p.Phe303Leu Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Pro257Ala Single submitter ⚠
- p.Pro261Leu Single submitter ⚠
- p.Pro261Ser Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Pro267Thr Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro286Gln Single submitter ⚠
- p.Pro290Ser Single submitter ⚠
- p.Pro290Thr Single submitter ⚠
- p.Pro339Arg Single submitter ⚠
- p.Pro378Ala Single submitter ⚠
- p.Ser141Gly Single submitter ⚠
- p.Ser263Leu Single submitter ⚠
- p.Ser269Ile Single submitter ⚠
- p.Ser277Leu Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Ser392Cys Single submitter ⚠
- p.Ser63Thr Single submitter ⚠
- p.Ser82Thr Single submitter ⚠
- p.Thr284Pro Single submitter ⚠
- p.Thr285Pro Single submitter ⚠
- p.Trp105Arg Single submitter ⚠
- p.Tyr345Cys Single submitter ⚠
- p.Tyr345His Single submitter ⚠
- p.Tyr93His Single submitter ⚠
- p.Val153Met Single submitter ⚠