DOK3 — 113 ClinVar variants
All ClinVar germline DOK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
7 Likely benign · 106 Uncertain significance
Full DOK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK3 c.-181C>T Uncertain significance Single submitter
- DOK3 c.-182G>A Uncertain significance Single submitter
- DOK3 c.-182G>C Uncertain significance Single submitter
- DOK3 c.-23C>T Uncertain significance Single submitter
- DOK3 c.-35G>A Uncertain significance Single submitter
- DOK3 c.-62C>T Uncertain significance Single submitter
- DOK3 c.-69G>A Uncertain significance Single submitter
- DOK3 p.Ala171Thr Uncertain significance Single submitter
- DOK3 p.Ala252Pro Uncertain significance Single submitter
- DOK3 p.Ala321Val Uncertain significance Single submitter
- DOK3 p.Ala332Gly Uncertain significance Single submitter
- DOK3 p.Ala395Thr Uncertain significance Single submitter
- DOK3 p.Ala56Gly Uncertain significance Single submitter
- DOK3 p.Arg141Lys Uncertain significance Single submitter
- DOK3 p.Arg209Cys Uncertain significance Single submitter
- DOK3 p.Arg225Cys Uncertain significance Single submitter
- DOK3 p.Arg253Cys Uncertain significance Single submitter
- DOK3 p.Arg257Gln Uncertain significance Single submitter
- DOK3 p.Arg368Cys Uncertain significance Single submitter
- DOK3 p.Arg3Pro Uncertain significance Single submitter
- DOK3 p.Arg3Trp Uncertain significance Single submitter
- DOK3 p.Arg439Pro Uncertain significance Single submitter
- DOK3 p.Arg65Gln Uncertain significance Single submitter
- DOK3 p.Arg8Gln Uncertain significance Single submitter
- DOK3 p.Asp279Val Uncertain significance Single submitter
- DOK3 p.Asp319Ala Uncertain significance Single submitter
- DOK3 p.Asp390Asn Uncertain significance Single submitter
- DOK3 p.Asp438Glu Uncertain significance Single submitter
- DOK3 p.Asp84Asn Uncertain significance Single submitter
- DOK3 p.Asp84Glu Uncertain significance Single submitter
- DOK3 p.Cys267Phe Uncertain significance Single submitter
- DOK3 p.Glu303Lys Uncertain significance Single submitter
- DOK3 p.Glu349Lys Uncertain significance Single submitter
- DOK3 p.Glu363Ala Uncertain significance Single submitter
- DOK3 p.Gly142Asp Uncertain significance Single submitter
- DOK3 p.Gly159Ser Uncertain significance Single submitter
- DOK3 p.Gly212Ser Uncertain significance Single submitter
- DOK3 p.Gly223Ser Uncertain significance Single submitter
- DOK3 p.Gly305Arg Uncertain significance Single submitter
- DOK3 p.Gly323Arg Uncertain significance Single submitter
- DOK3 p.Gly366Ser Uncertain significance Single submitter
- DOK3 p.Gly386Val Uncertain significance Single submitter
- DOK3 p.Gly4Arg Uncertain significance Single submitter
- DOK3 p.Gly4Glu Uncertain significance Single submitter
- DOK3 p.Gly62Glu Uncertain significance Single submitter
- DOK3 p.Ile12Val Uncertain significance Single submitter
- DOK3 p.Ile251Val Uncertain significance Single submitter
- DOK3 p.Leu106Pro Uncertain significance Single submitter
- DOK3 p.Lys140Arg Uncertain significance Single submitter
- DOK3 p.Lys177Asn Uncertain significance Single submitter
- DOK3 p.Pro145Leu Uncertain significance Single submitter
- DOK3 p.Pro335Thr Uncertain significance Single submitter
- DOK3 p.Pro361Thr Uncertain significance Single submitter
- DOK3 p.Pro387Leu Uncertain significance Single submitter
- DOK3 p.Pro436Arg Uncertain significance Single submitter
- DOK3 p.Pro63Ser Uncertain significance Single submitter
- DOK3 p.Ser130Pro Uncertain significance Single submitter
- DOK3 p.Ser219Phe Uncertain significance Single submitter
- DOK3 p.Ser60Leu Uncertain significance Single submitter
- DOK3 p.Val163Met Uncertain significance Single submitter
Predictors split 44
The independent predictors disagree with each other — read with care.
- DOK3 c.-102G>T Uncertain significance Single submitter
- DOK3 c.-92G>T Uncertain significance Single submitter
- DOK3 c.-98C>T Uncertain significance Single submitter
- DOK3 p.Ala180Val Uncertain significance Single submitter
- DOK3 p.Ala250Thr Uncertain significance Single submitter
- DOK3 p.Ala252Asp Uncertain significance Single submitter
- DOK3 p.Ala34Val Uncertain significance Single submitter
- DOK3 p.Arg102Gln Uncertain significance Single submitter
- DOK3 p.Arg102Gly Uncertain significance Single submitter
- DOK3 p.Arg111Cys Uncertain significance Single submitter
- DOK3 p.Arg173Cys Uncertain significance Single submitter
- DOK3 p.Arg255Trp Uncertain significance Single submitter
- DOK3 p.Arg257Trp Uncertain significance Single submitter
- DOK3 p.Arg26Gln Uncertain significance Single submitter
- DOK3 p.Arg331His Uncertain significance Single submitter
- DOK3 p.Arg399Gln Uncertain significance Single submitter
- DOK3 p.Arg428Cys Uncertain significance Single submitter
- DOK3 p.Arg428His Uncertain significance Single submitter
- DOK3 p.Arg49Trp Uncertain significance Single submitter
- DOK3 p.Arg69Gln Uncertain significance Single submitter
- DOK3 p.Arg90Gln Uncertain significance Single submitter
- DOK3 p.Arg90Leu Uncertain significance Single submitter
- DOK3 p.Asp214Asn Uncertain significance Single submitter
- DOK3 p.Asp319Tyr Uncertain significance Single submitter
- DOK3 p.Asp50Asn Uncertain significance Single submitter
- DOK3 p.Asp91Tyr Uncertain significance Single submitter
- DOK3 p.Cys24Arg Uncertain significance Single submitter
- DOK3 p.Glu101Lys Uncertain significance Single submitter
- DOK3 p.Glu86Lys Uncertain significance Single submitter
- DOK3 p.His206Tyr Uncertain significance Single submitter
- DOK3 p.Leu200Phe Uncertain significance Single submitter
- DOK3 p.Leu312Met Uncertain significance Single submitter
- DOK3 p.Lys419Glu Uncertain significance Single submitter
- DOK3 p.Pro124Ala Uncertain significance Single submitter
- DOK3 p.Pro124Leu Uncertain significance Single submitter
- DOK3 p.Pro310Leu Uncertain significance Single submitter
- DOK3 p.Pro414Leu Uncertain significance Single submitter
- DOK3 p.Pro82Leu Uncertain significance Single submitter
- DOK3 p.Ser427Asn Uncertain significance Single submitter
- DOK3 p.Thr295Met Uncertain significance Single submitter
- DOK3 p.Thr353Met Uncertain significance Single submitter
- DOK3 p.Tyr201Cys Uncertain significance Single submitter
- DOK3 p.Val217Met Uncertain significance Single submitter
- DOK3 p.Val40Met Uncertain significance Single submitter
All DOK3 variants
Likely benign 7
- c.-26C>T Single submitter
- p.Ala252Thr Single submitter
- p.Ala321= Single submitter
- p.Arg3Gln Single submitter
- p.Asn318Ser Single submitter
- p.Cys24Ser Single submitter
- p.Gly379Ser Single submitter
Uncertain significance 106
- c.-102G>T Single submitter ⚠
- c.-181C>T Single submitter ⚠
- c.-182G>A Single submitter ⚠
- c.-182G>C Single submitter ⚠
- c.-23C>T Single submitter ⚠
- c.-35G>A Single submitter ⚠
- c.-62C>T Single submitter ⚠
- c.-69G>A Single submitter ⚠
- c.-92G>T Single submitter ⚠
- c.-98C>T Single submitter ⚠
- c.*844A>G Single submitter
- c.*867C>T Single submitter
- p.Ala171Thr Single submitter ⚠
- p.Ala180Val Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala252Asp Single submitter ⚠
- p.Ala252Pro Single submitter ⚠
- p.Ala321Val Single submitter ⚠
- p.Ala332Gly Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala56Gly Single submitter ⚠
- p.Arg102Gln Single submitter ⚠
- p.Arg102Gly Single submitter ⚠
- p.Arg111Cys Single submitter ⚠
- p.Arg141Lys Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg253Cys Single submitter ⚠
- p.Arg255Trp Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg331His Single submitter ⚠
- p.Arg368Cys Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg3Pro Single submitter ⚠
- p.Arg3Trp Single submitter ⚠
- p.Arg428Cys Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg439Pro Single submitter ⚠
- p.Arg49Trp Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Arg90Leu Single submitter ⚠
- p.Asp214Asn Single submitter ⚠
- p.Asp279Val Single submitter ⚠
- p.Asp319Ala Single submitter ⚠
- p.Asp319Tyr Single submitter ⚠
- p.Asp390Asn Single submitter ⚠
- p.Asp438Glu Single submitter ⚠
- p.Asp50Asn Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Asp84Glu Single submitter ⚠
- p.Asp91Tyr Single submitter ⚠
- p.Cys24Arg Single submitter ⚠
- p.Cys267Phe Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Glu349Lys Single submitter ⚠
- p.Glu363Ala Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly142Asp Single submitter ⚠
- p.Gly159Ser Single submitter ⚠
- p.Gly212Ser Single submitter ⚠
- p.Gly223Ser Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Gly323Arg Single submitter ⚠
- p.Gly366Ser Single submitter ⚠
- p.Gly386Val Single submitter ⚠
- p.Gly4Arg Single submitter ⚠
- p.Gly4Glu Single submitter ⚠
- p.Gly62Glu Single submitter ⚠
- p.His206Tyr Single submitter ⚠
- p.Ile12Val Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Leu106Pro Single submitter ⚠
- p.Leu200Phe Single submitter ⚠
- p.Leu312Met Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Lys177Asn Single submitter ⚠
- p.Lys419Glu Single submitter ⚠
- p.Pro124Ala Single submitter ⚠
- p.Pro124Leu Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro310Leu Single submitter ⚠
- p.Pro335Thr Single submitter ⚠
- p.Pro361Thr Single submitter ⚠
- p.Pro387Leu Single submitter ⚠
- p.Pro414Leu Single submitter ⚠
- p.Pro436Arg Single submitter ⚠
- p.Pro63Ser Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser130Pro Single submitter ⚠
- p.Ser219Phe Single submitter ⚠
- p.Ser427Asn Single submitter ⚠
- p.Ser60Leu Single submitter ⚠
- p.Thr295Met Single submitter ⚠
- p.Thr353Met Single submitter ⚠
- p.Tyr201Cys Single submitter ⚠
- p.Val163Met Single submitter ⚠
- p.Val217Met Single submitter ⚠
- p.Val40Met Single submitter ⚠