DOK4 — 56 ClinVar variants
All ClinVar germline DOK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign · 55 Uncertain significance
Full DOK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK4 p.Ala191Thr Uncertain significance Single submitter
- DOK4 p.Ala204Thr Uncertain significance Single submitter
- DOK4 p.Ala294Gly Uncertain significance Single submitter
- DOK4 p.Ala294Pro Uncertain significance Single submitter
- DOK4 p.Arg189Gln Uncertain significance Single submitter
- DOK4 p.Arg200Trp Uncertain significance Single submitter
- DOK4 p.Arg222Cys Uncertain significance Single submitter
- DOK4 p.Arg236Gln Uncertain significance Single submitter
- DOK4 p.Arg54Gln Uncertain significance Single submitter
- DOK4 p.Arg70Trp Uncertain significance Single submitter
- DOK4 p.Arg77Trp Uncertain significance Single submitter
- DOK4 p.Asp95Ala Uncertain significance Single submitter
- DOK4 p.Cys67Tyr Uncertain significance Single submitter
- DOK4 p.Gln315Leu Uncertain significance Single submitter
- DOK4 p.Glu154Lys Uncertain significance Single submitter
- DOK4 p.Glu215Lys Uncertain significance Single submitter
- DOK4 p.Glu217Gln Uncertain significance Single submitter
- DOK4 p.Glu282Lys Uncertain significance Single submitter
- DOK4 p.Glu289Lys Uncertain significance Single submitter
- DOK4 p.Glu43Gln Uncertain significance Single submitter
- DOK4 p.Gly276Ser Uncertain significance Single submitter
- DOK4 p.Gly290Ala Uncertain significance Single submitter
- DOK4 p.Gly55Ala Uncertain significance Single submitter
- DOK4 p.Met241Val Uncertain significance Single submitter
- DOK4 p.Pro266Leu Uncertain significance Single submitter
- DOK4 p.Pro39Leu Uncertain significance Single submitter
- DOK4 p.Ser298Leu Uncertain significance Single submitter
- DOK4 p.Thr60Ile Uncertain significance Single submitter
- DOK4 p.Thr93Ala Uncertain significance Single submitter
- DOK4 p.Val177Ile Uncertain significance Single submitter
- DOK4 p.Val245Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- DOK4 p.Ala229Ser Uncertain significance Single submitter
- DOK4 p.Arg115Cys Uncertain significance Single submitter
- DOK4 p.Arg138Cys Uncertain significance Single submitter
- DOK4 p.Arg173Cys Uncertain significance Single submitter
- DOK4 p.Arg222His Uncertain significance Single submitter
- DOK4 p.Arg236Trp Uncertain significance Single submitter
- DOK4 p.Arg54Trp Uncertain significance Single submitter
- DOK4 p.Arg77Gln Uncertain significance Single submitter
- DOK4 p.Arg90Ser Uncertain significance Single submitter
- DOK4 p.Asp118Ala Uncertain significance Single submitter
- DOK4 p.Asp118Asn Uncertain significance Single submitter
- DOK4 p.Asp118Val Uncertain significance Single submitter
- DOK4 p.Asp95Asn Uncertain significance Single submitter
- DOK4 p.Cys259Gly Uncertain significance Single submitter
- DOK4 p.Glu134Gln Uncertain significance Single submitter
- DOK4 p.Ile8Met Uncertain significance Single submitter
- DOK4 p.Leu265Arg Uncertain significance Single submitter
- DOK4 p.Ser178Leu Uncertain significance Single submitter
- DOK4 p.Ser256Leu Uncertain significance Single submitter
- DOK4 p.Ser319Asn Uncertain significance Single submitter
- DOK4 p.Thr252Met Uncertain significance Single submitter
- DOK4 p.Thr262Met Uncertain significance Single submitter
- DOK4 p.Val151Met Uncertain significance Single submitter
- DOK4 p.Val68Ile Uncertain significance Single submitter
All DOK4 variants
Benign 1
- p.Glu74Asp Multiple submitters
Uncertain significance 55
- p.Ala191Thr Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala229Ser Single submitter ⚠
- p.Ala294Gly Single submitter ⚠
- p.Ala294Pro Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg173Cys Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222His Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg54Gln Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg70Trp Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Arg77Trp Single submitter ⚠
- p.Arg90Ser Single submitter ⚠
- p.Asp118Ala Single submitter ⚠
- p.Asp118Asn Single submitter ⚠
- p.Asp118Val Single submitter ⚠
- p.Asp95Ala Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Cys259Gly Single submitter ⚠
- p.Cys67Tyr Single submitter ⚠
- p.Gln315Leu Single submitter ⚠
- p.Glu134Gln Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu217Gln Single submitter ⚠
- p.Glu282Lys Single submitter ⚠
- p.Glu289Lys Single submitter ⚠
- p.Glu43Gln Single submitter ⚠
- p.Gly276Ser Single submitter ⚠
- p.Gly290Ala Single submitter ⚠
- p.Gly55Ala Single submitter ⚠
- p.Ile8Met Single submitter ⚠
- p.Leu265Arg Single submitter ⚠
- p.Met241Val Single submitter ⚠
- p.Pro266Leu Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Ser256Leu Single submitter ⚠
- p.Ser298Leu Single submitter ⚠
- p.Ser319Asn Single submitter ⚠
- p.Thr252Met Single submitter ⚠
- p.Thr262Met Single submitter ⚠
- p.Thr60Ile Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val245Met Single submitter ⚠
- p.Val68Ile Single submitter ⚠