DOK5 — 48 ClinVar variants
All ClinVar germline DOK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Likely benign · 47 Uncertain significance
Full DOK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DOK5 p.Ala34Thr Uncertain significance Multiple submitters
- DOK5 p.Ala34Pro Uncertain significance Single submitter
- DOK5 p.Arg185Gln Uncertain significance Single submitter
- DOK5 p.Arg186Gln Uncertain significance Single submitter
- DOK5 p.Arg186Trp Uncertain significance Single submitter
- DOK5 p.Asn117Ser Uncertain significance Single submitter
- DOK5 p.Asp87Asn Uncertain significance Single submitter
- DOK5 p.Asp87Gly Uncertain significance Single submitter
- DOK5 p.Cys104Tyr Uncertain significance Single submitter
- DOK5 p.Cys155Tyr Uncertain significance Single submitter
- DOK5 p.Gln270His Uncertain significance Single submitter
- DOK5 p.Gln280His Uncertain significance Single submitter
- DOK5 p.Gly216Arg Uncertain significance Single submitter
- DOK5 p.Gly38Asp Uncertain significance Single submitter
- DOK5 p.His224Arg Uncertain significance Single submitter
- DOK5 p.Ile210Thr Uncertain significance Single submitter
- DOK5 p.Lys44Arg Uncertain significance Single submitter
- DOK5 p.Lys77Arg Uncertain significance Single submitter
- DOK5 p.Lys77Glu Uncertain significance Single submitter
- DOK5 p.Met245Val Uncertain significance Single submitter
- DOK5 p.Met248Lys Uncertain significance Single submitter
- DOK5 p.Phe53Tyr Uncertain significance Single submitter
- DOK5 p.Pro180Ser Uncertain significance Single submitter
- DOK5 p.Ser304Pro Uncertain significance Single submitter
- DOK5 p.Thr191Asn Uncertain significance Single submitter
- DOK5 p.Thr191Pro Uncertain significance Single submitter
- DOK5 p.Val112Ile Uncertain significance Single submitter
- DOK5 p.Val174Ile Uncertain significance Single submitter
- DOK5 p.Val261Glu Uncertain significance Single submitter
- DOK5 p.Val261Leu Uncertain significance Single submitter
- DOK5 p.Val68Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DOK5 p.Arg236Leu Uncertain significance Single submitter
- DOK5 p.Arg253Trp Uncertain significance Single submitter
- DOK5 p.Cys165Tyr Uncertain significance Single submitter
- DOK5 p.Glu134Gly Uncertain significance Single submitter
- DOK5 p.Glu154Gln Uncertain significance Single submitter
- DOK5 p.Glu235Lys Uncertain significance Single submitter
- DOK5 p.Leu237Val Uncertain significance Single submitter
- DOK5 p.Leu246Phe Uncertain significance Single submitter
- DOK5 p.Leu293Arg Uncertain significance Single submitter
- DOK5 p.Lys175Arg Uncertain significance Single submitter
- DOK5 p.Ser120Asn Uncertain significance Single submitter
- DOK5 p.Ser136Asn Uncertain significance Single submitter
- DOK5 p.Ser36Arg Uncertain significance Single submitter
- DOK5 p.Thr278Met Uncertain significance Single submitter
- DOK5 p.Val106Ala Uncertain significance Single submitter
- DOK5 p.Val241Met Uncertain significance Single submitter
All DOK5 variants
Likely benign 1
- p.Thr191Ala Single submitter
Uncertain significance 47
- p.Ala34Thr Multiple submitters ⚠
- p.Ala34Pro Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg236Leu Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Asp87Asn Single submitter ⚠
- p.Asp87Gly Single submitter ⚠
- p.Cys104Tyr Single submitter ⚠
- p.Cys155Tyr Single submitter ⚠
- p.Cys165Tyr Single submitter ⚠
- p.Gln270His Single submitter ⚠
- p.Gln280His Single submitter ⚠
- p.Glu134Gly Single submitter ⚠
- p.Glu154Gln Single submitter ⚠
- p.Glu235Lys Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.His224Arg Single submitter ⚠
- p.Ile210Thr Single submitter ⚠
- p.Leu237Val Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu293Arg Single submitter ⚠
- p.Lys175Arg Single submitter ⚠
- p.Lys44Arg Single submitter ⚠
- p.Lys77Arg Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Met245Val Single submitter ⚠
- p.Met248Lys Single submitter ⚠
- p.Phe53Tyr Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Ser120Asn Single submitter ⚠
- p.Ser136Asn Single submitter ⚠
- p.Ser304Pro Single submitter ⚠
- p.Ser36Arg Single submitter ⚠
- p.Thr191Asn Single submitter ⚠
- p.Thr191Pro Single submitter ⚠
- p.Thr278Met Single submitter ⚠
- p.Val106Ala Single submitter ⚠
- p.Val112Ile Single submitter ⚠
- p.Val174Ile Single submitter ⚠
- p.Val241Met Single submitter ⚠
- p.Val261Glu Single submitter ⚠
- p.Val261Leu Single submitter ⚠
- p.Val68Ile Single submitter ⚠